高度経済成長期以降の佐久地方における養鯉業の展開

Carp breeding in rice paddy fields in the Saku district began in the Edo period and continued through the Meiji to the Taisho era up to 1955 (the 30th year of the Showa era). However, the business declined rapidly when the period of high economic growth began. One of the factors in the carp breeding decline could be the dwindling demand for carp because of changes in dietary habits and in consciousness about carp as food. Even after carp breeding in paddy fields declined, fresh water fish breeding has continued and thrives in farm ponds, which could also mean the continuation of carp breeding. One current tendency is that the number of people asking for carp is increasing because of activity deployment to re-evaluate regional tradition and the advertisements for Saku carp, which is a regional revitalization project. Along with the tendency, two potential business channels have been generated: local production with local consumption and express delivery service. Demand for carp has been increasing among people who believe the traditional idea that eating carp has positive therapeutic impact.Carp breeding in rice paddy fields in the Saku district began in the Edo period and continued through the Meiji to the Taisho era up to 1955 (the 30th year of the Showa era). However, the business declined rapidly when the period of high economic growth began. One of the factors in the carp breeding decline could be the dwindling demand for carp because of changes in dietary habits and in consciousness about carp as food. Even after carp breeding in paddy fields declined, fresh water fish breeding has continued and thrives in farm ponds, which could also mean the continuation of carp breeding. One current tendency is that the number of people asking for carp is increasing because of activity deployment to re-evaluate regional tradition and the advertisements for Saku carp, which is a regional revitalization project. Along with the tendency, two potential business channels have been generated: local production with local consumption and express delivery service. Demand for carp has been increasing among people who believe the traditional idea that eating carp has positive therapeutic impact

高度経済成長期以降の佐久地方における養鯉業の展開

Carp breeding in rice paddy fields in the Saku district began in the Edo period and continued through the Meiji to the Taisho era up to 1955 (the 30th year of the Showa era). However, the business declined rapidly when the period of high economic growth began. One of the factors in the carp breeding decline could be the dwindling demand for carp because of changes in dietary habits and in consciousness about carp as food. Even after carp breeding in paddy fields declined, fresh water fish breeding has continued and thrives in farm ponds, which could also mean the continuation of carp breeding. One current tendency is that the number of people asking for carp is increasing because of activity deployment to re-evaluate regional tradition and the advertisements for Saku carp, which is a regional revitalization project. Along with the tendency, two potential business channels have been generated: local production with local consumption and express delivery service. Demand for carp has been increasing among people who believe the traditional idea that eating carp has positive therapeutic impact.Carp breeding in rice paddy fields in the Saku district began in the Edo period and continued through the Meiji to the Taisho era up to 1955 (the 30th year of the Showa era). However, the business declined rapidly when the period of high economic growth began. One of the factors in the carp breeding decline could be the dwindling demand for carp because of changes in dietary habits and in consciousness about carp as food. Even after carp breeding in paddy fields declined, fresh water fish breeding has continued and thrives in farm ponds, which could also mean the continuation of carp breeding. One current tendency is that the number of people asking for carp is increasing because of activity deployment to re-evaluate regional tradition and the advertisements for Saku carp, which is a regional revitalization project. Along with the tendency, two potential business channels have been generated: local production with local consumption and express delivery service. Demand for carp has been increasing among people who believe the traditional idea that eating carp has positive therapeutic impact

液态CO_2多致裂管爆破同步性及爆破效果优化试验研究

现场进行爆破作业时,为提升爆破效果,往往布设多个钻孔,同时起爆。实际上,多致裂管起爆的时间差较大,同步性较难控制,直接影响爆破效果。本文提出一种提升液态CO2多致裂管爆破同步性方法,保持现有致裂管主体结构不变,将药包直接粘贴在防爆片上。通过开展致裂管爆破对比试验,对爆破全过程进行压力数据采集。经数据对比分析发现,原有致裂管内药包与防爆片分置在致裂管两端,药包点燃后,需通过致裂管内的液态CO2传递压力,击破防爆片共需30-60ms,优化后不足20ms,可明显降低爆破时间的不确定性,这种条件下多管串并联爆破更容易实现同步性。另外,通过开展对比试验研究,在其他条件不变的前提下,增大致裂管出气口面积20%,可有效增大总冲量值10%,提升爆破效果

Experiment on micron-sized particle production of iron ore by rapid unloading of liquid CO2

The average iron content of iron ore is &lt;30%; therefore, crushing, grinding, milling and other processing techniques must be executed before smelting. Currently, it is expensive to break iron ores using mechanical grinding. Experiments have been carried out to develop a novel approach of producing iron ore powder. First, the iron ore is placed in a high-pressure chamber, and then liquid CO2 is injected into the chamber. Second, considering energy recycling, after the iron ore pores are filled with liquid CO2, dissociative liquid CO2 is substituted and collected for cyclic utilization. Third, an initial high pressure is applied inside the chamber using a water pump in order to increase the energy input. Fourth, the pressure is rapidly unloaded. After penetration and gasification expansion, the iron ore will immediately be converted into micron-sized particles. Laser grain size analysis indicated that the grain size of the iron ore particles ranges between 30 and 50 pm, which will satisfy the requirements of gravity separation, magnetic separation and the flotation process. This is a highly efficient and low-cost method that has excellent industrial promotion value. (C) 2017 Elsevier B.V. All rights reserved.</p

苯胺嘧啶衍生物X-9通过下调整合素β1表达抑制肝细胞癌迁移侵袭

整合素在许多肿瘤细胞中高表达，并且参与肿瘤细胞的侵袭转移。在肝细胞癌中，整合素β1被报导高表达，并促进肿瘤细胞的侵袭。目前，对于整合素的表达调控癌细胞机制以及干预其表达进而抑制肿瘤细胞转移的研究较少。本研究探讨利用小分子化合物抑制整合素表达来抑制肿瘤细胞迁移和侵袭的可能。首先，对临床肝癌细胞患者癌组织和癌旁组织中的整合素β1的表达进行检测，发现其在癌组织中的表达显著高于癌旁组织（P<0.05）。对TCGA肿瘤数据库的生物信息学分析结果同样显示，整合素β1的高表达与肝癌的分期（P=0.019）和预后（P=0.013）相关。通过筛选发现，苯胺嘧啶衍生物X-9可以抑制肝癌细胞中整合素β1的mRNA和蛋白质的表达（P<0.01）。细胞划痕愈合实验和细胞穿孔结果显示，苯胺嘧啶衍生物X-9能够抑制肝癌细胞的迁移和侵袭（P<0.01）。进一步的研究证实，在肝癌细胞中外源表达整合素β1可以逆转X-9对肝癌细胞迁移和侵袭的抑制；而在敲除整合素β1的细胞中，X-9对细胞的迁移和侵袭的抑制被消除。因此，鉴定出苯胺嘧啶衍生物X-9可以通过下调整合素β1表达，进而抑制肝癌细胞的迁移和侵袭。福建省自然科学基金（No.2016J05087,No.2017J01201）;;福建省卫计委医疗创新项目（No.2015-CXB-15

Application of a three-dimensional visualization technology for precise before retroperitoneal tumor surgery(Report of 15 cases)

目的探讨三维可视化技术在腹膜后肿瘤术前评估中的应用价值。方法回顾性分析2011年3月至2013年12月厦门大学附属成功医院收治的15例腹膜后肿瘤病人的临床资料,应用三维可视化技术将病人术前二维CT图像进行三维可视化重建,通过观察肿瘤与腹腔脏器、腹部大血管之间的关系及测量肿瘤体积、手术模拟进行术前评估。对实施手术的病人,比较重建结果与实际手术的区别,对模拟切除肿瘤体积与实际切除肿瘤体积进行相关性分析。结果 15例病人三维可视化重建后图像清晰立体地显示肿瘤组织、腹腔实质脏器、腹腔大血管的解剖结构及毗邻关系,12例评估后行腹膜后肿瘤切除术,三维重建肿瘤的解剖关系与术中大致相符。12例手术病人术前模拟切除肿瘤体积(1117.50±690.35)M l,实际切除肿瘤体积(1189.92±737.74)M l,两者比较差异无统计学意义(T=0.25,P>0.05),具有相关性(r=0.81,P0.05).The actual liver resection volume was positively correlated with the predicted liver resection volume(r=0.81, P<0.05).Conclusions The three-dimensional visualization technology has acertain degree of clinical value in the precise before retroperitoneal tumor surgery.国家自然科学基金资助(No.81272246;81101502;61271336;61327001

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学