Comparison of Jiawei Xiaoyao Pills in treating women with emotional disorder during perimenopause

目的:探讨加味逍遥丸治疗围绝经期情绪障碍的优势。方法:经筛选后具有抑郁或焦虑的围绝经期女性患者80例随机等分为帕罗西汀组、利维爱组、帕+利组和加味逍遥丸组,分别给予相应药物治疗8周。所有患者在治疗前后均进行1次围绝经期症状主诉量表(grEEnE)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMd)评定,并在观察期结束时进行副反应量表(TESS)评定。结果:grEEnE、HAMA评分:4种治疗方法均能改善,且相互间无统计学差异;HAMd评分:除利维爱组均有效改善(P<0.01),帕+利组和加味逍遥丸组优于帕罗西汀组(P<0.05),且帕+利组和加味逍遥丸组间无统计学意义;TESS评分:前3组与加味逍遥丸组比较均有统计学意义(P<0.01),评分均大于加味逍遥丸组,且前3组间无统计学差异。结论:考虑到帕罗西汀的毒副作用和利维爱潜在的、远期的危险性,治疗该病加味逍遥丸值得推荐。Objective: To explore the superiority of Jiawei Xiaoyao Pills in treating perimenopausal women with emotional disorder.Methods: 80 perimenopausal women with emotional disorder screened by SAS and SDS were randomly divided into 4 equal groups: Paroxetine group, Livial group, Paroxetine combined with Livial group, Jiawei Xiaoyao Pills group, 20 in each group.All of them accepted 8 weeks' therapy.Every patient accepted the assessment of these rating scales(including Greene, HAMA, HAMD) one time before and after treatment, and only one test for TESS after treatment.Results: All regimens improved the score of Greene and HAMA, and there was no statistical dif erence between dif erent regimens.Except Livial group, the other regimens ef ectively improved the score of HAMD(P<0.01).The score of HAMD in Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group was increased, better than Paroxetine group(P<0.05), and there was no statistical dif erence between Paroxetine combined with Livial group and Jiawei Xiaoyao Pills group(P<0.05).There was no signii cant dif erence in TESS score between the i rst 3 groups, but they all had a higher score than Jiawei Xiaoyao Pills group, and the dif erences were statistically signii cant(P<0.01).Conclusion: Considering the side ef ects of paroxetine and latent, long-term risk of Livial, the regimen of Jiawei Xiaoyao Pills therapy deserved to be advocated in the clinical practice for the disease.国家自然科学青年基金项目(No.81302960)~

Evaluation on difference of therapeutic efficacy of Jiawei Xiaoyao Granules and Pills in treatment of emotional disorder during perimenopause based on Greene Climacteric Scale

目的:在前期加味逍遥丸治疗围绝经期情绪障碍具有比较优势的基础上,基于grEEnE量表探讨其颗粒剂和丸剂不同剂型间疗效差异。方法:经筛选后患有情绪障碍的围绝经期女性75例随机等分为A、b、C3组,分别对应采用帕罗西汀、加味逍遥丸和加味逍遥颗粒剂治疗8周。所有患者在治疗前后各进行1次grEEnE及其子因子评定,并在观察期结束时进行TESS评定。结果:grEEnE总分差及其焦虑、抑郁因子分差:3种治疗方法均能改善,且相互间无显著差异;grEEnE性因子和血管因子分差:后二组均优于A组(P<0.01);TESS评分:与A组比较,b、C组均有统计学意义(P<0.01),评分均小于A组,且后二组间无显著差异。结论:加味逍遥的2种剂型间疗效无显著差异,考虑到帕罗西汀的不良反应,治疗该病加味逍遥的2种剂型都值得推荐。Objective: To investigate the difference in therapeutic efficacy between Jiawei Xiaoyao Granules and pills based on the preliminary research of treating emotional disorder during perimenopause with Jiawei Xiaoyao Pills and Greene Climacteric Scale.Methods: 75 female patients with emotional disorder during perimenopause were slected and randomly divided into 3 groups as group A, B and C.Patients in the 3 groups were treated with paroxetine, Jiawei Xiaoyao Pills and Jiawei Xiaoyao Granules respectively for 8 weeks.Greene and Greene factors assessment were carried out in all the patients before and after treatment, and the TESS assessment was carried out at the end of the observation period.Results: The three therapies all could improve the gap in total score of Greene and its factors as anxiety and depressed, and the difference among these three groups was no significant.The factors of Greene and gap in score of vascular factors of group B and C was better than that of group A(P<0.01).The difference in TESS score between group A and group B and C was significant(P<0.01), while the difference between group B and group C was not significant.Conclusion: The difference in curative effect between the two formulations was not significant.Because of the adverse reactions of paroxetine, in the treatment of emotional disorder during perimenopause, the two formulations of Jiawei Xiaoyao Powder were worth to be recommended.国家自然科学青年基金项目(No.81302960)~