Health Economic Evaluation of Cervical Cancer Prevention Strategies based on System Dynamics Model

人民健康是民族昌盛和国家富强的重要标志，应放在优先发展的战略地位。坚持预防为主，倡导健康文明生活方式，预防控制重大疾病。然而，政府和个人的医疗负担愈加沉重，人均医疗费用快速增长的势头仍未彻底逆转。作为经济学与医疗的交叉学科，卫生经济学专注于如何解决有效配置医疗资源。针对重大疾病预防，权衡当期的预防费用支出和远期的产出，对科学地定量化地规划医疗政策具有重要作用，同时也将是未来的发展方向之一。宫颈癌是女性常见的恶性肿瘤，也是目前唯一病因明确、可以早期预防和治疗、可以消灭的癌症。HPV疫苗价格较高，不合理地推广使用无疑将加重政府和个人的医疗负担。为了优化医疗资源配置和寻找最优的宫颈癌预防策略，本研究...People's health is an important symbol of national prosperity, which should be put in the strategic position of priority development. We should adhere to prevention, advocate a healthy and civilized lifestyle and prevent major diseases. However, the per capita medical expense was still rising dramatically, which imposed heavy burdens to individuals, families, and society. As an interdisciplinary s...学位：经济学博士院系专业：经济学院_统计学学号：1542013015397

数学模型在HPV疫苗经济学评估中的研究进展

人乳头状瘤病毒(HuMAn PAPIllOMA VIruS,HPV)持续感染引起宫颈癌、肛门癌和生殖器疣等多种HPV相关疾病。其中,宫颈癌和生殖器疣已严重威胁到人群的生命健康[1-6],其防治工作成为当前亟待解决的公共卫生问题。预防性HPV疫苗已经被证明可以有效阻断HPV感染和降低人群宫颈癌和生殖器疣发病率,并且其已在多个国家获得了使用许可[4]。HPV疫苗接种方案的经济学评估对科学规划HPV疫苗接种方案和优化卫生资源配置有着重要作福建省科技厅科技计划项目(2013R0091); 教育部人文社会科学研究项目(12YJA790030); 福建省自然科学基金计划资助项目(2012J01303

Infection Status and Influencing Factors of Human Papillomavirus in Patients with Condylomata Acuminata

目的了解我国内地尖锐湿疣（CA）患者的人乳头瘤病毒（HPV）感染状况,并探讨其影响因素。方法系统检索Pub Med、Science Direct Online、中国知网、万方数据知识服务平台、维普网中关于我国内地CA患者HPV检测的文献,检索时间均为1990年1月—2013年12月。根据样本量对各文献HPV感染率进行加权合并,计算CA患者的HPV及各基因型合并感染率,并分析不同研究年份、研究地区CA患者的HPV合并感染率,采用多因素Logistic回归分析探讨CA患者感染/检出HPV的影响因素。结果共纳入文献67篇,累计CA患者10 757例,感染HPV 9 328例（86.7%）。CA患者的HPV合并感染率为95.7%〔95%CI（95.2%,96.2%）〕,其中合并感染率较高的前3种基因型为HPV6/11〔81.2%,95%CI（77.1%,85.2%）〕、HPV6〔43.8%,95%CI（35.2%,52.5%）〕、HPV11〔38.3%,95%CI（32.8%,43.8%）〕。1990—2003、2004—2013年CA患者的HPV合并感染率分别为96.6%〔95%CI（95.8%,97.5%）〕、94.6%〔95%CI（94.0%,95.3%）〕;东、中、西部患者的HPV合并感染率分别为95.1%〔95%CI（94.4%,95.7%）〕、91.7%〔95%CI（89.3%,94.1%）〕、96.5%〔95%CI（95.4%,97.6%）〕。多因素Logistic回归分析结果显示,研究年份、研究地区、标本类型、诊断方法是CA患者感染/检出HPV的影响因素（P〈0.05）。对不同基因型进行分析,结果显示,研究年份、研究地区、标本类型、诊断方法是CA患者感染/检出HPV6的影响因素,研究年份、研究地区为西部、标本类型、诊断方法是CA患者感染/检出HPV11的影响因素,研究地区为中部、标本类型是CA患者感染/检出HPV16的影响因素,研究地区、标本类型、诊断方法是CA患者感染/检出HPV18的影响因素（P〈0.05）。结论我国内地CA患者的HPV感染以HPV6、HPV11基因型为主,感染率近10年来有所下降,东部地区感染率较高。病理检查确诊、采用剥落细胞进行DNA检测,可以提高CA患者的HPV检出率。Objective To study the infection status of human papillomavirus（HPV） in patients with condylomata acuminata（CA） in mainland China and explore its influencing factors. Methods The literatures on HPV detection of CA patients in mainland China published between January 1990 and December 2013 were systematically retrieved from Pub Med,Science Direct Online, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and the VIP database. According to the sample size,HPV infection rates of each literature were weighted and combined and the infection rates of HPV and the combined infection rate of each genotype of CA patients were calculated,and the combined infection rate of HPV of CA patients in different years and areas of study was analyzed. Multivariate Logistic regression analysis was used to investigate the influencing factors of CA patients infected / detected with HPV. Results A total of 67 literatures were included in the study. The number of CA patients accumulated to 10 757,and 9 328 cases（86. 7%） infected with HPV. The combined infection rate of HPV in patients with CA was 95. 7% 〔95% CI（95. 2%,96. 2%） 〕,and the top three genotypes with high infection rate were HPV6 /11 〔81. 2%,95% CI（77. 1%,85. 2%） 〕, HPV6 〔43. 8%,95% CI（35. 2%,52. 5%） 〕, HPV11〔38. 3%,95% CI（32. 8%,43. 8%） 〕. The combined infection rate of HPV in patients with CA between 1990 and 2003 and between 2004 and 2013 was 96. 6% 〔95% CI（95. 8%,97. 5%） 〕and 94. 6% 〔95% CI（94. 0%,95. 3%） 〕respectively;the combined infection rate of HPV of patients in eastern, middle and western areas was 95. 1% 〔95% CI（94. 4%,95. 7%） 〕,91. 7% 〔95% CI（89. 3%,94. 1%） 〕,and 96. 5% 〔95% CI（95. 4%,97. 6%） 〕respectively. Multivariate Logistic regression analysis showed that the year of study,areas of study,type of specimen and methods of diagnosis significantly influenced the infection and detection of HPV in CA patients（P 0. 05）. After analyzing different genoty福建省自然科学基金青年项目（2014J05097

Autophagy Inhibition by Chloroquine Sensitizes Cervical Cancer SiHa Cells to CPT Treatment

自噬诱导是肿瘤细胞对化疗药物抵抗性的原因之一,该研究探讨溶酶体抑制剂氯喹对喜树碱(camptothecin,CPT)诱导的宫颈癌细胞Si Ha死亡的增敏效果。CPT和/或氯喹处理宫颈癌Si Ha细胞,MTT法检测细胞增殖,DAPI和TUNEL染色观察细胞凋亡,Western blot和免疫荧光检测自噬及凋亡相关蛋白。结果发现,CPT处理后,Si Ha细胞MAP1LC3B荧光点和LC3II(microtubuleassociated protein light chain 3II)蛋白水平增加,p62荧光点和蛋白质水平则减少;而采用氯喹特异抑制自噬后,可明显提高CPT诱导的细胞凋亡、caspase-9的激活和PARP(poly ADP-ribose polymerase)的切割,而全长caspase-2水平显著下降。以上结果提示,氯喹可通过抑制细胞自噬而增强宫颈癌细胞株Si Ha对CPT诱导细胞凋亡的敏感性。The autophagy induction is one of the reasons for the resistance of tumor cells to chemotherapy drugs. In this study, the enhanced sensitivity of cervical cancer Si Ha cells to camptothecin(CPT)-induced cell death by chloroquine(a lysosome inhibitor) was investigated. The cell viability was detected by MTT assay, meanwhile, apoptosis was observed by DAPI and TUNEL, autophagy related proteins and apoptosis proteins were analyzed by immunofluorescence(IF) staining and Western blot in Si Ha cells after CPT treatment alone or combined with chloroquine. The results found that in Si Ha cells with CPT treatment the autophagy related protein LC3 foci and microtubule-associated protein light chain 3II(LC3II) protein level was increased, but p62 foci and protein level was decreased. When autophagy was inhibited by chloroquine, the CPT-induced apoptosis was obviously enhanced, and caspase-9 was activated and PARP was cleaved, but full length caspase-2 was decreased. Taken together, these results indicated that the inhibition of autophagy by chloroquine could sensitize cervical cancer Si Ha cells to CPT inducing cell apoptosis.山西省自然科学基金(批准号:2014021037-9);; 山西医科大学汾阳学院博士启动基金(批准号:1301);山西医科大学汾阳学院科研项目基金(批准号:1422)资助的课题~

The development and application of high-quality and efficient management expert system of Kiwifruit

猕猴桃优质高效管理专家系统是在 Window NT(4.0 )环境下开发的 ,适用于 Internet的一个人工智能软件系统 ,该系统由苗木繁殖技术、高接换种技术、整形修剪技术、疏蕾授粉疏果技术、果园生草技术、优化施肥技术、节水灌溉技术、病虫害防治技术、冻害预防技术、果品保鲜贮藏技术和系统维护等 14个子系统组成 ,介绍了系统结构及其实现技术。应用示范结果表明 ,该系统指导的 6 6 .6 7hm2示范果园年增产值 90 0 0元 / hm2 ,推广辐射的 6 70 0 hm2果园年增产值 2 840万元

Multi-level encryption and authentication type WIA-PA network handheld device communication method

本发明涉及一种用于高安全多级加密与认证的WIA-PA网络的手持设备的通信方法，所述的WIA-PA网络包含网关、路由设备和现场设备。所述手持设备可以采用两种方式与WIA-PA网络中的设备进行安全通信。第一种方法，与WIA-PA网络中的设备建立点对点的通信，在链路层进行加密；第二种方法，手持设备加入WIA-PA网络，入网后采用多级的加密技术与WIA-PA网络设备进行通信。所述的两种方法的结合，能够保证安全的同时，使所述的手持设备快速的与网络中的设备建立通信，具备功耗低、速度快、对网络性能影响小的特点。</p

DRONE-BASED MONITORING ON GREEN TIDE ALONG COASTAL TOURISM AREA

RGB images were taken by a drone-borne camera and analyzed using four-color indices to monitor and identify green tide in the coastal scenic area in Haiyang, Shandong. Monitoring indices in different locations were specified. The results show that the characteristic values of G-band are greater than the other bands' and the color indices could be used for green tide monitoring. For different places of the green tide outbreak, NGBDI (normalized green-blue difference) index is applicable for monitoring floating green tide at sea, and GLI (green leaf index) index for green tide monitoring on beach

Information extraction of Ulva Prolifera from coastal landscape using UAV m ultispectral remote sensing images

Since 2007, green tides(also called Ulva prolifera) occurred every summer in the Yellow Sea, causing ecological problems in the coastal environment of Shandong Peninsula . A large number of Ulva prolifera on shore will rot and stink if not handled in time,which seriously affects the tourism and the health of residents in coastal landscape. In order to improve the accuracy of monitoring green tide disasters, and to improve the efficiency of the cleaning up and disposal of Ulva prolifera at key prevention and control area, In this study, the high-precision image of UAV is used to monitor the green tide disaster in Yintan landscape of Rushan City. With the spectral characteristics of Ulva prolifera and coastal vegetation measured by spectroradiometer, four vegetation indices were used to analyze and identify the Ulva prolifera and coastal vegetation, and to verify the extraction of Ulva prolifera and coastal vegetation under different vegetation indices, and based on this extraction method, the biomass of coastal green tide algae was estimated. The results show that in the red-edge band,Ulva prolifera and coastal vegetation can be distinguished. MTCI(MERIS terrestrial chlorophyll index) is more suitale,with the accuracy of 91.3%, followed by SR_(redge),NDVI_(redge) and MSR_(redge),with the accuracy of 85.3%, 83.8% and 81.2%, respectively; Estimation model of biomass based on MTCI index showed that about 600 tons of Ulva prolifera were estimated in 300 m study area. An effective method for dynamic monitoring and cleaning up of green tide disaster is provided