Mass Spectrometry-based Analysis of Phosphorylation Pattern of RNA Polymerase II CTD by P-TEFb

在真核细胞中，RNA聚合酶II（RNAPolII）负责大多数编码蛋白质mRNA和核内小RNA（snRNA）基因的转录，其碳端结构域（CTD）为RNA聚合酶II所特有，在结合转录循环和基因表达中扮演着重要的角色，转录循环过程中，TFIIH和P-TEFb是参与其磷酸化修饰调控的重要通用转录因子。其中，P-TEFb不仅是一种通用转录因子，同时也是艾滋病毒（HIV-1）转录复制过程中不可或缺的宿主转录因子之一。P-TEFb对CTD磷酸化模式的分析一直是研究热点。然而，CTD高度磷酸化状态及其七肽重复结构（YSPTSPS）等特性使其质谱分析面临巨大挑战。 本课题首先建立P-TEFb磷酸化RNA聚合酶I...The RNA polymerase II is responsible not only for transcription of thousands of protein-coding genes constituting the largest group of distinct individual genes in the eukaryotic genome, but also for genes encoding small noncoding RNAs (snRNA). Furthermore, it is found that the carboxyl-terminal domain (CTD) of RNA polymerase II is unique to this eukaryotic RNA polymerase. TFIIH and P-TEFb are imp...学位：医学硕士院系专业：药学院_药物分析学学号：3232014115342

正史乐志书写方式对《礼记・乐记》的继承与发展

Yueji is the most important document for systematically recording the music of the pre-Qin period. The Annals of Music in the official Chinese history books has become the main text carrier after the book of Yueji. Yueji had a profound influence on later music literature, either on the concept of music or on the description of music, though it does not especially record the music’s history. Based on the analysis of Yueji, this thesis will take the Annals of Music in Shih Chi, Hanshu and Songshu as a focus for research into the profound inheritance and development between them. As for Yueji, the value of the political function of music has been recognized, and the method of music writing has been changed. The evolution of music literature records and reflects changes in the concept of ritual music

Grid Resource Management Model Based on ESA

提出了基于ESA的网格资源管理模型。该模型以Service-Agent为基础,结合了Agent动态自主性和服务的松散耦合优点,运用经济学的市场机制和交易理论,提出该模型的资源发现机制、分配选择机制和交易机制,以及基于议价交易机制的Bargaining_Min_min算法,实现资源的优化管理,使资源提供者和使用者满足各自利益,达到网格市场上的双赢。A service-agent grid resource management model based on economic mechanisms is proposed.Based on Service-Agent,it combines the dynamic agent with loose coupling of services.The market mechanisms and trading theories such as resource discovery mechanism,resource allocation mechanism and Bargaining_Min_min based on bargaining mechanism,are also adopted to achieve the optimal allocation of grid resources so that providers and consumers can maximize their own interests and try to get the win-win objective in grid market.“985工程”智能化科技创新平台基金资助项

Research on Grid Architecture and Resource Management Framework

网格技术是近几年研究较为热门的一项技术，它把整个互联网整合成一台巨大的超级计算机，实现计算资源、存储资源、数据资源、信息资源、知识资源等的全面共享。网格体系结构是关于如何构建网格的技术，是设计网格系统最重要的基础性研究工作，它需能够标识出网格的基本组成成分，能够清楚地说明网格整体是由哪些关键部分结合在一起形成的，还必须能够对各个部分的功能、目的、特点等进行清晰地描述，使人们能够了解各个组成部分的作用。同时，网格最重要的作用就是如何把分布在不同地域的不同资源进行整合，因此如何设计一个合理、有效的资源管理框架和机制也是网格系统的研究重点之一，在这个资源管理框架下资源的调度是最关键的。本文首先介绍了...The grid technology is a hot technique developed in recent years, which integrate worldwide Internet resource into a virtual supercomputer, accomplish compute resource, storage resource, data resource, information resource, and knowledge resource to full share in global. The research of grid architecture is the base of grid systems design. It should sign the components of grid system, illuminate t...学位：工学硕士院系专业：软件学院_计算机技术学号：20044000

基于SOA的三维信息网格体系结构研究

在总结现有网格体系结构的基础上, 针对所存在的问题, 从网格资源使用和功能管理、面向用户操作以 及网格系统自身特性等角度分析设计了相应的架构layer、tier和vertica,l 并且全面考虑这三种架构思想的各个 作用因素, 提出了基于SOA 的三维信息网格体系结构( 3D IGA ) 原型, 并对其中一些关键技术和问题进行了研 究, 提出了一些诸如网格服务代理器、资源集成池、服务工厂等重要的概念。最后将该三维信息网格体系结构应 用到海洋信息网格集成系统的软件框架上。“985工程”智能化国防信息安全技术科技创新平台项目( 0000-X-07204

基于ESA 的网格资源管理模型

提出了基于ESA 的网格资源管理模型。该模型以Service-Agent 为基础，结合了Agent 动态自主性和服务的松散耦合优点，运用 经济学的市场机制和交易理论，提出该模型的资源发现机制、分配选择机制和交易机制，以及基于议价交易机制的Bargaining_Min_min 算 法，实现资源的优化管理，使资源提供者和使用者满足各自利益，达到网格市场上的双赢。“985 工程”智能化科技创新平台基金资助项

Propagated error analysis of digital elevation models generated by bi-cubic hermite interpolation methods

2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe