Design of Sequences with Good Folding Properties in Coarse-Grained Protein Models

Background: Designing amino acid sequences that are stable in a given target structure amounts to maximizing a conditional probability. A straightforward approach to accomplish this is a nested Monte Carlo where the conformation space is explored over and over again for different fixed sequences, which requires excessive computational demand. Several approximate attempts to remedy this situation, based on energy minimization for fixed structure or high-$T$ expansions, have been proposed. These methods are fast but often not accurate since folding occurs at low $T$. Results: We develop a multisequence Monte Carlo procedure, where both sequence and conformation space are simultaneously probed with efficient prescriptions for pruning sequence space. The method is explored on hydrophobic/polar models. We first discuss short lattice chains, in order to compare with exact data and with other methods. The method is then successfully applied to lattice chains with up to 50 monomers, and to off-lattice 20-mers. Conclusions: The multisequence Monte Carlo method offers a new approach to sequence design in coarse-grained models. It is much more efficient than previous Monte Carlo methods, and is, as it stands, applicable to a fairly wide range of two-letter models.Comment: 23 pages, 7 figure

School Catalog

The catalog for the Siegel-Myers Correspondence School of Music detailing information about the School, its instructors, classes offered, and the nature of the correspondence courses.https://digitalcommons.colum.edu/sherwood_smcs/1000/thumbnail.jp

Outline of A Course of Lessons in Choral Conducting

A pamphlet outlining the lesson plans during the choral conducting correspondence coursehttps://digitalcommons.colum.edu/sherwood_smcs/1002/thumbnail.jp

Diabetes : A Growing Challenge in Obesity

ABSTRACT There are three major types of the diabetes: type 1, type 2, gestational diabetes. Type 1 diabetes starts from childhood and pancreas stops producing insulin. Type 2 diabetes our body can't use the insulin it makes. Type 3 diabetes Diabetes when you're expecting affects about 4% of all U.S. pregnancies [1]. It's caused by placenta hormones or by too little insulin. High blood sugar from the mother causes high blood sugar in the baby. This results in growth and development problems if left untreate

Pancreatic Cancer as a Landmark in Humans

ABSTRACT Cancer diseases still a troublesome human diseases and area unit robust to cure with restricted knowledge concerning the mechanisms of their development. Pancreatic ductal glandular cancer (PDAC) is one amongst the foremost common malignant tumors still associated with poor prognosis in advanced stages. This text may be a reference of the areas of cancer wherever this day work is concentrated on and this array of deep study cans sure as shooting leads to several facilitating changes within the treatment of cancer. Cancer diseases still a troublesome human diseases and area unit robust to cure with restricted knowledge concerning the mechanisms of their development. The studies have incontestable associate inflated prevalence of malignant neoplastic disease among female subpopulations of the tending trade, beside radiologists, radiology technicians, and orthopaedic surgeons. The association between cancer and radiation exposure is well established, and additionally the female breast is very in danger of the cancer-causing effects of radiation Patients with chronic inflammation (CP) might have shown resembling carcinoma (PaC) and also are risky for developing PAC, patitients with this normally gift with abdominal pain, symptom, weight loss or preventive jaundice that gibe those of carcinoma (PaC) from ductal glandular cancer and cause diagnostic confusion Pancreatic ductal glandular cancer (PDAC) is one amongst the foremost common malignant tumors still associated with poor prognosis in advanced stages. Gemcitabine is one amongst the quality agents for the treatment of PDAC Nuclear issue Of Activated T cells (NFAT) transcription factors promote exocrine gland carcinogenesis via distinct transcriptional programs resulting in augmented proliferation and growth, inhibition of crucial fail-safe mechanisms and interference with key tumor-suppressor functions "Microsatellites" area unit presently one among the foremost used genetic markers (outlined as loci) where short sequences of desoxyribonucleic acid square measure perennial in bike arrays. Their high length polymorphism and abundance altogether genomes build them the sequence of choice for a numerous vary of applications spanning linkage analysis and genetic mapping through to rhetorical and ecological and process studies Squamous cell cancer of the head and neck (HNSCC) is an evolving space of clinical and analysis focus with a rising prevalence of the illness within the females. Some human papillomavirus (HPV) varieties act as carcinogens that contribute to the event of HNSCC. Head and neck cancers of the cavity (hereafter abbreviated as HNSCC) generally originate inside the damp epithelial cell linings of the bodily cavity, lips, rima, secretion glands, tongue, taste bud, pharyx, and cartilaginous structur