2 research outputs found
Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice
We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil
dietary administered at three concentrations (0.4% thyme and 0.2% oregano
oils; 0.2% thyme and 0.1%
oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis.
Treatment of colitic
animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines
IL-1β, IL-6, GM-CSF, and
TNFα, especially after application of the medium dose. The medium dose of the
essential oils significantly
lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the
mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic
damage of the colonic
tissue. Our results indicate that combined treatment with appropriate concentrations of thyme
and oregano
essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate
TNBS-induced
colitis in mice