Ankstyvo nediferencijuoto artrito sociodemografinių, klinikinių, radiologinių ir laboratorinių rodiklių reikšmė šios ligos baigčiai

This study evaluated the role of sociodemographic, clinical, ultrasound, and laboratory variables, which are usually assessed in everyday rheumatologist clinical practice, for the outcomes of UA. The association of VEGF levels and SNPs (rs2476601, rs833070, rs6920220) with the UA parameters mentioned above, and their significance for the disease outcomes was also assessed. VEGF levels were significantly associated with RA poor prognosis markers and were also significantly lower in subjects diagnosed with inflammatory spondyloarthropathy during the study period. The investigated VNPs had no association with the risk to develop RA, although subjects with polymorphism rs6920220 GG and GA genotypes had a higher number of tender joints at the study baseline. Based on the data from published literature, for the first time, the gene expression of TLR1, TLR2, TLR4, inflammasomes (NLRP1, NLRP3), and VDR, as well as secretion of MMP-1, MMP-7, MMP-8, MMP-12, MMP-13, and interleukin-1β were measured, in knee SF from subjects with UA, RA, and OA and data compared with results obtained from control group SF analysis. In the UA group significantly higher TLR4 gene expression in unstimulated SF and NLRP3 expression in TNFα-stimulated SF was detected compared to the RA group. Meanwhile, after SF stimulation with TNFα in combination with VitD3, the expression of MMP-12 in the UA group was statistically lower than in the OA group

The significance of sociodemographic, clinical, radiological and laboratory findings in the outcomes of early undifferentiated arthritis.

This study evaluated the role of sociodemographic, clinical, ultrasound, and laboratory variables, which are usually assessed in everyday rheumatologist clinical practice, for the outcomes of UA. The association of VEGF levels and SNPs (rs2476601, rs833070, rs6920220) with the UA parameters mentioned above and their significance for the disease outcomes were also assessed. VEGF levels were significantly associated with RA poor prognosis markers and were also significantly lower in subjects diagnosed with inflammatory spondyloarthropathy during the study period. The investigated VNPs had no association with the risk to develop RA, although subjects with polymorphism rs6920220 GG and GA genotypes had a higher number of tender joints at the study baseline. Based on the data from published literature, for the first time, the gene expression of TLR1, TLR2, TLR4, inflammasomes (NLRP1, NLRP3), and VDR, as well as secretion of MMP-1, MMP-7, MMP-8, MMP-12, MMP-13, and interleukin-1β were measured, in knee SF from subjects with UA, RA, and OA, and data compared with results obtained from control group SF analysis. In the UA group significantly higher TLR4 gene expression in unstimulated SF and NLRP3 expression in TNFα-stimulated SF was detected compared to the RA group. Meanwhile, after SF stimulation with TNFα in combination with VitD3, the expression of MMP-12 in the UA group was statistically lower than in the OA group

VEGF profile in early undifferentiated arthritis cohort

Background and Objectives: Early undifferentiated arthritis (UA) is a group of inflammatory joint diseases that are not classified under any specific rheumatic or connective tissue disorder and might evolve into chronic inflammatory arthritis or may be a self-limiting condition. Early recognition and treatment are crucial for the future course of the disease. Vascular endothelial growth factor (VEGF) is an angiogenic regulator that induces the growth of new capillary blood vessels, which are important in joint invasion and destruction during the progression of chronic inflammatory arthritis. The aim of this study was to assess VEGF levels associated with sociodemographic, clinical, laboratory, and ultrasound findings in the early UA patient cohort as well as to evaluate VEGF as a potential prognostic marker for arthritis outcomes. Materials and Methods: Seventy-six patients with inflammatory arthritis in at least one joint, with a duration of arthritis <12 months at the study entry that did not meet any rheumatic disease classification criteria, were enrolled after informed consent was obtained. Patient’s sociodemographic, laboratory data, and clinical disease characteristics were recorded, VEGF levels were measured, and ultrasound (US) of tender and swollen joints was performed. Results: VEGF levels had positive correlation with conventional rheumatic disease activity and diagnostic markers: erythrocyte sedimentation rate (ESR), C–reactive protein (CRP), and rheumatoid factor (RF) (p < 0.05). RF-positive patients had higher VEGF values (p = 0.024). A statistically higher number of patients whose VEGF levels were below the median value presented with active infection (p = 0.046). In patients with a higher number of swollen joints, and a higher score of synovitis and power doppler (PD) seen on US, VEGF levels were statistically significantly higher. Patients who after 12-month follow-up developed rheumatoid arthritis (RA) had statistically higher VEGF levels at baseline compared with those who developed spondyloarthropathies (p = 0.028). Conclusions: This study demonstrated that VEGF levels significantly represented inflammatory processes that were present in the joints (number of swollen joints, synovitis, and PD changes) of the early UA cohort