Çağdaş Türk tiyatrosunun toplumcu gerçekçi yazarlarından İsmet Küntay’ı anarken:Duyarlı ve eleştirel gözle daha güzele...

Taha Toros Arşivi, Dosya No: 200-Yazarlar ve Yönetmenlerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

The effects of storage temperature and storage time on the somatic cell count of anatolian buffaloes

This research examined the effects of storage temperature and storage time on the somatic cell count (SCC) of milk from Anatolian buffaloes, which was measured with the DeLaval cell counter (DCC). Storage temperature and time are among the different factors that potentially affect the SCC of Anatolian buffalo milk. In this context, 20 milk samples were collected from Anatolian Buffaloes and analyzed. The milk samples were divided into two groups according to their measured level of SCC. These two groups were the low score (?3.16 cell/ml) group and the high score (>3.16 cell/ml) group. The mean logSCC values of the low score and the high score groups were determined as 2.27±0.045 and 4.06±0.019 cells/ml, respectively. In this research, the effects of storage temperature (4ºC, 21ºC) and storage time (fresh milk, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 24 h) on logSCC were determined to be statistically significant (P<0.01). Thus, increases in storage temperature and storage time were associated with an increase in the logSCC of the milk samples. © 2019, International Buffalo Information Center, Kasetsart University. All rights reserved

Determination of Direct and Indirect Effects on Milk Yield of Anatolian Buffaloes Using Path Analysis

This study aimed to determine the direct and indirect effects of the independent variables presented by the lactation length (LL), age of calving (CAGE), and daily milk yield (DMY) on the dependent variable of lactation milk yield (LMY) in Anatolian buffaloes. In this study, 3761 LMY records of the 834 Anatolian buffaloes calving between 2012 and 2017 in Tokat province and around were used as the research material. In the study, the simple correlation coefficients between the dependent variable of LMY and independent variables were determined to be positive and significant (P[removed

Fatty acid profilies and some meat quality traits at different slaughter weights of Brown Swiss bulls

This research was done to detect some meat quality traits and tissue fatty acid combination of the longissimus dorsi thoracis (LT) muscle of Brown Swiss bulls at the different slaughter weights (SW). The animal material of the study comprised 20 Brown Swiss bulls. In the study, Brown Swiss bulls were divided into two groups according to their SW as low (LSW (n = 10); 431–503 kg) and high (HSW (n = 10); 504–583 kg). In the study, the LSW group showed the lowest final pH value (pHF) (5.44) (P 0.05). In the research, the differences observed between the SW groups considering a* (redness) and C (chroma) values were found significant (P 0.05). Freeze–thaw loss (FL) and ether extract (PEE) were found 4.35% and 1.01% higher, respectively, in the HSW group than the LSW group (P 0.05) in the LT muscle decreased with the increase of SW. As a result, when LSW and HSW slaughter weight groups were evaluated considering the water losses causing financial losses in meat and fatty acids having beneficial effects on human health, it was seen that the LSW group came to the fore. © 2021, The Author(s), under exclusive licence to Springer Nature B.V

RETRACTED: Successful treatment for a giant coronary saccular aneurysm complicated with myocardial infarction in a patient with Behcet's disease: Case report

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Corresponding Author.A complaint previously filed by a physician in Turkey claimed that the treatment reported in this article was administered by himself, not by the authors, and that the case report also plagiarized an abstract he reported in an international conference. The issue was investigated by the ethics committee of the Turkish Higher Education Council which ruled in 2014 that there was no ethical violations associated with the case.After the recourse of the physician to Ankara 16th Administrative Court, the court decided on a stay of execution of the previous decision of the ethics committee of the Higher Educational Council

Erythropoietin Improves the Healing of Skin Necrosis Resulting From Doxorubicin Extravasation in a Rat Model

AbstractBackgroundDoxorubicin is an antineoplastic agent that causes skin necrosis when extravasated. Various agents have been tried to reduce tissue damage owing to extravasation. Erythropoietin (EPO) is an obligatory growth factor for red blood cells and has beneficial effects on wound healing.ObjectiveThe aim of this study was to test the hypothesis that local EPO injection can prevent and improve healing of necrosis at the doxorubicin injection site in rats.MethodsWe used 31 female Sprague-Dawley rats. The dorsal area of each rat was shaved, and 2 mg of doxorubicin in 0.5 mL saline was injected intradermally. The rats were then divided into 3 groups: control; control with intradermal injection of saline; and treatment, which received an intradermal injection of EPO. EPO in saline was injected into 4 quadrants of the same site where doxorubicin was injected 1 hour before. The rats were monitored and the area of each ulcer was measured. Skin biopsies were excised at the end of 4 weeks using anesthetic pentobarbital. Inflammation, edema, epithelization, neovascularization, necrosis, fibroblast proliferation, and collagen synthesis were evaluated and compared between groups.ResultsThe average areas of the lesions were significantly smaller in the EPO-injected rats (P = 0.03). The histopathologic evaluation revealed that the scores for epithelization, neovascularization, fibroblast proliferation, and collagen synthesis were higher (P < 0.001, P < 0.001, P = 0.002, and P = 0.04, respectively) and the score for necrosis was lower (P < 0.001) in the EPO-injected group than in both the saline-injected and control groups.ConclusionsIn this study using female Sprague-Dawley rats, EPO treatment improved the healing of skin necrosis caused by doxorubicin injection. This finding may lead to a new therapeutic approach for the management of skin necrosis caused by doxorubicin extravasation

Aminotiyazollerin benzimidazol, benzotiyazol, benzofuran ve naftofuran türevlerinden yeni bileşiklerin sentezi ve antimikrobiyal etkilerinin değerlendirilmesi

The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, new compounds containing thiazole and benzimidazole/benzothiazole/benzofurane/naphtofurane rings were synthesized, and their antimicrobial effects were evaluated. 9 compounds were synthesized by converting the seconder and cyclic amines to thiourea, and continued by thiazole ring closure. Ring closure was achieved by methylene-carbonyl condensation except conventional methods. Compound characterization was realized by FT-IR, 1 H NMR and 13C NMR and HRMS. Compounds did not show significant activity on bacterial strains. Nine aminothiazole derivatives have been synthesized successfully. Compounds did not show important antibacterial activity and thus were evaluated as inactive.Tiyazol halkası, birçok alanda biyolojik aktivite oluşturan moleküllerin çekirdeğidir. Bu aktiviteler arasında antikonvülsan, antimikrobiyal, antitüberküloz, antiviral vb. farmakolojik etkiler yer almaktadır. Bu çalışmada sekonder/siklik aminlerden yola çıkılarak tiyazol ve benzimidazol/benzotiyazol/benzofuran/naftofuran halkaları içeren yeni tiyazol türevleri sentezlenmiş ve antimikrobiyal etkileri değerlendirilmiştir. Bileşiklerin sentezinde, sekonder veya siklik aminler tiyoüreye dönüştürülerek 9 bileşik sentezlenmiş ve tiyazol halka kapanması ile devam edilmiştir. Halka kapatma, konvansiyonel yöntemler dışında metilen-karbonil kondenzassyonuyla gerçekleşmiştir. Bileşiklerin karakterizasyonu FT-IR, 1 H NMR ve 13C NMR ve HRMS ile gerçekleştirilmiştir. Bileşikler, bakteri suşları üzerinde önemli aktivite göstermedi. 9 aminotiyazol türevi başarıyla sentezlenmiştir. Bileşikler önemli bir antibakteriyel etki göstermediğinden inaktif olarak tanımlanmıştır

Horner's syndrome following uncomplicated internal jugular vein catheterization: A case report

Perkütan internal juguler ven kateterizasyonu, santral venöz kateterizasyon uygulamalarında oldukça yaygın kullanılmaktadır. Santral venöz kateterizasyon uygulamaları sırasında nadir bir komplikasyon olarak Horner sendromu gelişebilir. Bu yazıda sağ internal juguler ven kateterizasyonundan bir gün sonra miyozis, pitozis ve anizokorinin eşlik ettiği Horner sendromu gelişen 47 yaşında kadın hasta sunuldu. Bir hafta sonra, hastanın klinik bulguları düzeldi.Percutaneous cannulation of the internal jugular vein is widely used for central venous cannulations. Horner's syndrome may develop as a rare complication of internal jugular vein cannulation. We presented a 47-year-old female patient who developed Horner's syndrome one day after uncomplicated internal jugular venous cannulation, which was accompanied by miosis, ptosis, and anisocoria. The symptoms improved within a week

Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles

Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological activities. In this study, nine novel 2-[(1,5-diphenyl-1H-imidazole-2-yl)thio]-N-(thiazole-2-yl)acetamide derivatives (Compound 1-9) were synthesized via the reaction of 1,5-disubstitued phenyl-imidazole-2-thiole and N-thiazole acetamide. The inhibitory effects of COX-1 and COX-2 enzymes were tested for the synthesized compounds. Enzyme-ligand interactions of the most active compound on COX subtypes were elucidated by molecular modeling studies. The percent inhibitory effect for compound 1, which is the naked derivative among all the compounds, was found to be the most active on COX-2 at 10 mu M concentration (C1(COX-2): 88%, SC-560(COX-2): 98.2%, C1(COX-1): 60.9%); whereas compound 9 showed the highest inhibitory effect and was found to be the most selective derivative on COX-1 isoenzyme (C9(COX-1): 85%, DuP-697(COX-1): 97.2%, C9(COX-2): 57.9%)

Comparison of diferent lactation curve models of Anatolian Bufaloes

Bu araştırmada, farklı işletme koşullarında 2011-2013 yılları arasında yetiştirilen Anadolu mandalarına ait kontrol günü süt verim kayıtları kullanılarak sekiz farklı laktasyon eğrisi modeli karşılaştırılmıştır. Bu amaçla, laktasyon eğrisinin tanımlanmasında Wood, Cobby ve Le Du, Üssel, Parabolik Üssel, Kuadratik, Ters Polinomiyal, Logaritmik Kuadratik, Logaritmik Linear modelleri kullanılmıştır. Laktasyon eğrisini en iyi tanımlayan modeli belirlemek için belirtme (R2) ve kalıntı standart sapma (KSS) katsayıları kriter olarak kullanılmıştır. En yüksek R2 ve en düşük KSS değerlerini veren Logaritmik Kuadratik ve Kuadratik modellerin en iyi uyumu gösteren modeller olduğu belirlenmiştir. Sonuç olarak, Logaritmik Kuadratik veya Kuadratik modeller ile tahmin edilen parametrelerin ıslah çalışmalarında kullanılması, bu yönde yapılacak araştırmalara önemli katkı sağlayacaktır.In this study, eight diferent lactation curve models were compared by using test day milk yield records belonging Anatolian Bufaloes raised in diferent Farm conditions between 2011 and 2013. To identify the best lactation curve models of Wood, Cobby and Le Du, Logaritmic Quadratic, Exponential, Parabolic exponential, Quadratic, Inverse Polynomial and Logaritmic Linear mathematical functions were used. The coefficient of determination (R2) and residual standard deviation (RSD) statistics were used for determination of best fitted model in lactation curve. Logaritmic Quadratic and Quadratic functions are the best goodness of fit model as having the highest R2 and lowest RSD coefficients. As a result, the parameters are estimated by logarithmic quadratic or quadratic models, for use in breeding programs will make an important contribution to research in this field