Correlation between hepatocyte growth factor receptor and vascular endothelial growth factor-A in breast carcinoma.

The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II treated with primary surgery. We have observed a strong correlation between VEGF-A and c-met. No correlations were found between VEGF-A or HGFR expressions and clinical parameters (tumor size, grade, axillary lymph node status, age), 5- and 10-years DFS or OS. Our study did not reveal any prognostic value of c-met or VEGF. In addition they are not useful to separate a patients' subgroup with poor prognosis. Unlike in other authors' studies, our patients' group is very homogenous which might tribute to obtained results

Should supplementary radiotherapy be used in patients with early stage of Hodgkin’s lymphoma? A vote for yes

Hodgkin’s lymphoma (HL) belongs to the most radiosensitive and chemosensitive cancers. Combined modality therapy is the preferred treatment for patients with classical favorable early-stage HL. However, late toxicity still remains an issue. A modern approach in HL radiotherapy includes implementation of sophisticated and dedicated delivery techniques together with the lower doses and smaller fields, which allow for reduction of early and late toxicity. In recent years, the question on the need for complementary radiotherapy in the early stages of Hodgkin’s lymphoma has been increasingly raised. The aim of the present review is to discuss the current role of radiotherapy and its potential future developments, with a focus on major clinical trials.Hodgkin’s lymphoma (HL) belongs to the most radiosensitive and chemosensitive cancers. Combined modality therapy is the preferred treatment for patients with classical favorable early-stage HL. However, late toxicity still remains an issue. A modern approach in HL radiotherapy includes implementation of sophisticated and dedicated delivery techniques together with the lower doses and smaller fields, which allow for reduction of early and late toxicity. In recent years, the question on the need for complementary radiotherapy in the early stages of Hodgkin's lymphoma has been increasingly raised. The aim of the present review is to discuss the current role of radiotherapy and its potential future developments, with a focus on major clinical trials

Czy u chorych na wczesnego chłoniaka Hodgkina należy stosować uzupełniającą radioterapię? Głos na tak

Chłoniak Hodgkina należy do najbardziej promieniowrażliwych i chemiowrażliwych nowotworów. Radioterapia pełni kluczową rolę w jego leczeniu we wczesnym stadium zaawansowania, jako komponenta leczenia skojarzonego. Istotną kwestią pozostaje późna toksyczność takiego leczenia. Nowoczesne podejście do radioterapii, które obejmuje zaawan­sowane techniki napromieniania oraz redukcje dawek i obszarów tarczowych, pozwoliło na zmniejszenie wczesnej oraz późnej toksyczności. W ostatnich latach coraz częściej stawiane jest pytanie o konieczność uzupełniającej radioterapii we wczesnych stadiach chłoniaka Hodgkina. Praca ta jest próbą odpowiedzi na to pytanie w świetle ostatnio opublikowanych dowodów naukowych