Probable effects of glutatione s-transferase p1 gene exon-6 (ala114val) polimorphism on the etiology of lung cancer

Objectives: Genetic susceptibility also has significanteffects on the etiology of lung cancer, besides smoking.Previously it has been reported that some genetic polymorphismshave important roles; especially Glutatyon STransferazP1 (GSTP1) gene for the development of lungcancer. GSTP1 gene has a role in phase II of xenobioticmetabolism. GSTP1 Exon-6 polymorphisms have functionaleffects on gene production and causes differencesin enzyme activity.The aim of this study was to investigateprobable effects of GSTP1gene exon-6 (ala114val) polimorphismon the etiology of lung cancer.Materials and methods: Our research population consistsedof 160 subjects; 80 as control group and 80 sufferingfrom lung cancer. Genomic DNA was extractedfrom peripheral blood leukocytes and the genotypes havebeen determined by using PCR and RFLP methods.Results: No effect of exon 6 (ala114val) polymorphismgenotype of GSTP1 gene were found on etiology of lungcancer in present study. This study showed that smoking,old age and being male are important risk factors forlung cancer. Additionally, our sample’s GSTP1 gene exon6 (ala114val) polymorphism genotype frequencies weredetermined.Conclusions: Our data derived from present study didnot suggest an effect of GSTP1gene exon-6 (ala114val)polimorphism on the etiology of lung cancer.Key words: Polimorphism of GSTP1 - exon-6 (ala114val)- lung cancer