Efficacy of Surgical Excision in Combination with Mitomycin C and Postoperative Topical 0.002% Mitomycin C Administration for Treatment of Conjunctival Intraepithelial Neoplasia

Purpose: To evaluate the efficacy of surgical excision in combination with mitomycin C (mit-C) and postoperative topical mit-C 0.002% administration for the treatment of conjunctival intraepithelial neoplasia (CIN). Material and Method: Twelve eyes of twelve patients who were histopathologically diagnosed as CIN between March 2004 and July 2008 were evaluated retrospectively for their treatment modalities and results. All lesions were excised with wide margins in combination with mit-C 0.02% application for 2 minutes. Five of 12 eyes were treated with topical mit-C 0.002% eye drops four times a day for 14 days after histopathological confirmation. Large conjunctival defects in 5 eyes were reconstructed with amniotic membrane (3 eyes) and autologous conjunctiva (2 eyes). Results: Seven patients were women and 5 were men, with a mean age of 68.37 (range: 30-94) years. The right eye was involved in 6 patients and the left one - in 6 patients. The conjunctival lesion was located on the nasal conjunctiva in 5 eyes and on the temporal one - in 7 eyes. Histopathological diagnosis was CIN in all cases. After a mean follow-up period of 41.75 months (between 10 and 62 months), one recurrence (8.3%) was noted. This case with recurrent lesion has been previously treated with surgical excision in combination with mit-C 0.02% application and the large conjunctival defect has been reconstructed with amniotic membrane. Discussion: Surgical excision in combination with mit-C and use of additional postoperative topical mit-C 0.002% in selected cases for conjunctival intraepithelial treatment provides a safe and effective cure. (Turk J Ophthalmol 2011; 41: 138-42

Simultane Bilateral Fakoemulsifikasyon ve Göz İçi Lens İmplantasyonu

Pur po se: To assess the visual outcomes, benefits, and drawbacks of simultaneous same-day phacoemulsification and intraocular lens (IOL) implantation in patients having bilateral cataracts. Ma te ri al and Met hod: The medical records of 346 patients (692 eyes) with bilateral cataracts who have undergone simultaneous bilateral cataract extraction (SBCE) with phacoemulsification and IOL implantation performed by a single surgeon (LA), were reviewed retrospectively. Outcome measures were intraoperative and postoperative complications, best-corrected postoperative visual acuity (BCVA), refractive errors, and patient satisfaction. Re sults: BCVA increased in 633 (91.5%) eyes, decreased in 12 (1.73%) eyes, and remained the same in 47 (6.8%) eyes. The incidence of intraoperative complications was 7.2% (n=50). These complications included posterior capsule rupture with vitreous loss in 20 eyes (2.8%) and without vitreous loss in 17 eyes (2.4%), zonular dehiscence in 9 eyes (1.3%), IOL haptic fracture in 2 eyes (0.28%), iridodialysis in 1 eye (0.14%), and nuclear drop in 1 eye (0.14%). Late postoperative complications occurred in 31 eyes (4.5%). Dis cus si on: With a careful preoperative evaluation performed by an experienced surgeon under strict surgical protocol, simultaneous bilateral phacoemulsification and IOL implantation may be a beneficial procedure.surgical success rate. (Turk J Ophthalmol 2013; 43: 149-55