Wirkung einer langfristigen Prolylhydroxylase-Inhibition auf die myokardiale Kapillarisierung im Tiermodell der subtotal nephrektomierten Ratte

Background and aims: Chronic kidney disease, as a cardiovascular risk factor in its own right, is associated with significant cardiovascular morbidity and mortality. Thus, they are assuming increasing medical and health economic importance worldwide in the treatment of the underlying renal disease and cardiovascular complications. Cardiovascular diseases are the leading cause of death in patients with chronic kidney disease. In renal and cardiac diseases, hypoxia plays a decisive role in the disease process and in further disease progression. Under hypoxic conditions, the maintenance of oxygen homeostasis occurs through the activation of selected genes such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF) under the control of the transcription factor complex hypoxia-inducible factor 1 (HIF-1), whereby the regulation of angiogenesis plays a decisive role. The capacity for adaptive angiogenesis is limited in chronic kidney disease as a result of reduced availability of HIF-1α. Pharmacological inhibition of prolyl hydroxylase (PHD) leads to the activation of various HIF target genes as a result of HIF accumulation or HIF stabilisation, so that prolyl hydroxylase inhibitors have already been used in numerous studies in the context of renal failure, myocardial infarction, stroke or hindlimb ischaemia. The exact mechanisms of action of prolyl hydroxylase inhibitors on the cardiovascular system in chronic kidney disease are still unclear. Therefore, the aim of the present study was to investigate the effect of long-term pharmacological inhibition of prolyl hydroxylase using 2-(1-chloro-4-hydroxyisoquinoline-3-carbox-amido)acetate (ICA) for HIF activation on myocardial capillarisation in the animal model of the subtotal nephrectomised rat. Materials and methods: The animal model of the subtotal nephrectomised rat was used to induce chronic kidney disease. Male CD® (Sprague Dawley) IGS rats were injected intraperitoneally with the prolyl hydroxylase inhibitor ICA at a dose of 25 mg/kg body weight once a week over a period of 8 weeks beginning at week 4 after surgical 5/6 nephrectomy. This experimental group (SNX+ICA) was compared with 5/6 nephrectomised animals untreated with medication (SNX) and sham-operated animals as a control group (SHAM). In order to assess the success of the therapy, myocardial capillarisation, the extent of left ventricular hypertrophy and interstitial myocardial fibrosis were analysed by histological staining. An echocardiographic examination was performed at the end of the experiment to assess cardiac function. Renal function was monitored regularly by determining creatinine clearance, albuminuria and renal retention parameters in blood plasma and 24-hour urine collection. Results and observations: Compared to the control group, there was a statistically non-significant decrease in myocardial capillarisation after 5/6 nephrectomy with a simultaneous increase in interstitial myocardial fibrosis and left ventricular hypertrophy. Long-term pharmacological inhibition of prolyl hydroxylase by ICA resulted in a non-significant improvement in myocardial capillarisation and a non-significant decrease in interstitial myocardial fibrosis and left ventricular hypertrophy due to HIF activation. The cardiac function parameters (CO, EF, FS, SV) determined in cardiac echocardiography showed a decrease in the cardiac pump function in the subtotal nephrectomised rats, whereas the long-term administration of ICA led to an improvement in cardiac performance. As a result of chronic kidney disease due to 5/6 nephrectomy, there was a significant increase in renal retention parameters in the blood plasma as well as significant albuminuria with a simultaneous significant decrease in creatinine clearance compared to control animals. Treatment with ICA led to a statistically non-significant regression of renal retention parameters in the blood plasma and albuminuria as well as an increase in creatinine clearance. (Practical) conclusions and discussions: In conclusion, this animal study demonstrated a non-significant improvement of myocardial capillarisation by long-term pharmacological inhibition of prolyl hydroxylase by ICA in the animal model of the subtotal nephrectomised rat. HIF activation by ICA resulted in a statistically non-significant improvement or regression of cardiac remodelling by decreasing left ventricular hypertrophy and interstitial myocardial fibrosis in direct association with restored increased capillary density. Thus, ICA improved cardiac pumping efficiency. With regard to the kidney, long-term treatment with ICA led to a statistically non-significant improvement in renal function, whereas renal weight or mass remained unaffected by prolyl hydroxylase inhibition. Therefore, activation of HIF-1α by pharmacological inhibition of prolyl hydroxylase could be the target of a potential therapeutic intervention to improve myocardial angiogenesis in chronic kidney disease and even contribute to the reduction of myocardial infarction area by improving postischaemic myocardial capillarisation in chronic kidney disease.Hintergrund und Ziele: Die chronischen Nierenerkrankungen sind als ein eigenständiger kardiovaskulärer Risikofaktor mit einer erheblichen kardiovaskulären Morbidität sowie Mortalität verbunden. So nehmen sie weltweit einen zunehmenden medizinischen sowie gesundheitsökonomischen Stellenwert in der Behandlung der renalen Grunderkrankung und der kardiovaskulären Komplikationen ein. Die kardiovaskulären Erkrankungen stellen hierbei die führenden Todesursachen bei Patienten mit chronischen Nierenerkrankungen dar. Die Hypoxie spielt bei renalen und kardialen Erkrankungen eine entscheidende Rolle im Krankheitsgeschehen und im weiteren Krankheitsprogress. Unter hypoxischen Bedingungen erfolgt der Erhalt der Sauerstoffhomöostase durch die Aktivierung von ausgewählten Genen wie Erythropoetin (EPO) und vaskulärer endothelialer Wachstumsfaktor (VEGF) unter Kontrolle des Transkriptionsfaktorkomplexes Hypoxie-induzierter Faktor 1 (HIF-1), wobei die Regulation der Angiogenese eine entscheidende Rolle spielt. Die Kapazität zur adaptiven Angiogenese ist bei einer chronischen Nierenerkrankung infolge einer verminderten Verfügbarkeit von HIF-1α eingeschränkt. Eine pharmakologische Inhibition der Prolylhydroxylase (PHD) führt infolge einer HIF-Akkumulation bzw. HIF-Stabilisierung zur Aktivierung von diversen HIF-Zielgenen, sodass Prolylhydroxylase-Inhibitoren bereits in zahlreichen Studien im Rahmen eines Nierenversagens, Myokardinfarktes, Schlaganfalles oder einer Hinterlaufischämie eingesetzt wurden. Die genauen Wirkmechanismen von Prolylhydroxylase-Inhibitoren auf das kardiovaskuläre System bei chronischen Nierenerkrankungen sind noch unklar. Daher war das Ziel der vorliegenden Arbeit die Wirkung einer langfristigen pharmakologischen Inhibition der Prolylhydroxylase mittels 2-(1-chloro-4-hydroxyiso-quinolin-3-carbox-amido)acetat (ICA) zur HIF-Aktivierung auf die myokardiale Kapillarisierung im Tiermodell der subtotal nephrektomierten Ratte zu untersuchen. Material und Methoden: Zur Induktion einer chronischen Nierenerkrankung wurde das Tiermodell der subtotal nephrektomierten Ratte verwendet. Bei männlichen CD® (Sprague Dawley) IGS Ratten wurde über einen Zeitraum von 8 Wochen beginnend ab der 4. Woche nach operativer 5/6-Nephrektomie der Prolylhydroxylase-Inhibitor ICA in einer Dosis von 25 mg/kg Körpergewicht einmal wöchentlich intraperitoneal injiziert. Dieser Versuchsgruppe (SNX+ICA) wurden 5/6-nephrektomierte medikamentös unbehandelte Tiere (SNX) sowie scheinoperierte Tiere als Kontrollgruppe (SHAM) gegenübergestellt. Um den Therapieerfolg beurteilen zu können, wurden unter anderem die myokardiale Kapillarisierung, das Ausmaß der linksventrikulären Hypertrophie und die interstitielle Myokardfibrose durch histologische Färbungen analysiert. Zur Beurteilung der Herzfunktion wurde zu Versuchsende eine echokardiographische Untersuchung durchgeführt. Die Nierenfunktion wurde regelmäßig durch die Bestimmung der Kreatinin-Clearance, Albuminurie und der Nierenretentionsparameter im Blutplasma sowie im 24-Stunden-Sammelurin überwacht. Ergebnisse und Beobachtungen: Im Vergleich zur Kontrollgruppe kam es nach 5/6-Nephrektomie zu einer statistisch nicht signifikanten Abnahme der myokardialen Kapillarisierung bei einer gleichzeitigen Zunahme der interstitiellen Myokardfibrose sowie zu einer linksventrikulären Hypertrophie. Die langfristige pharmakologische Inhibition der Prolylhydroxylase mittels ICA führte infolge der HIF-Aktivierung zu einer nicht signifikanten Verbesserung der myokardialen Kapillarisierung sowie zu einer nicht signifikanten Abnahme der interstitiellen Myokardfibrose und der linksventrikulären Hypertrophie. Die in der Herzechokardiographie ermittelten kardialen Funktionsparameter (HZV, EF, FS, SV) zeigten eine Abnahme der Pumpfunktion des Herzens bei den subtotal nephrektomierten Ratten, wohingegen die langfristige Gabe von ICA zu einer Verbesserung der Herzleistung führte. Infolge der chronischen Nierenerkrankung durch 5/6-Nephrektomie kam es im Vergleich zu den Kontrolltieren zu einem signifikanten Anstieg der Nierenretentionsparameter im Blutplasma sowie zu einer signifikanten Albuminurie bei einer gleichzeitigen signifikanten Abnahme der Kreatinin-Clearance. Die Behandlung mit ICA führte laborchemisch zu einer statistisch nicht signifikanten Regredienz der Nierenretentionsparameter im Blutplasma und der Albuminurie sowie zu einer Zunahme der Kreatinin-Clearance. (Praktische) Schlussfolgerungen und Diskussion: Zusammenfassend konnte in dieser tierexperimentellen Studie eine nicht signifikante Verbesserung der myokardialen Kapillarisierung durch eine langfristige pharmakologische Inhibition der Prolylhydroxylase mittels ICA im Tiermodell der subtotal nephrektomierten Ratte gezeigt werden. Die HIF-Aktivierung mittels ICA führte zu einer statistisch nicht signifikanten Verbesserung bzw. Regression des kardialen Remodelings durch eine Abnahme der linksventrikulären Hypertrophie sowie der interstitiellen Myokardfibrose in direkter Assoziation mit einer wiederhergestellten erhöhten Kapillardichte. Hierdurch bewirkte ICA eine Verbesserung der kardialen Pumpleistung. In Bezug auf die Niere führte eine langfristige Behandlung mit ICA zu einer statistisch nicht signifikanten Verbesserung der Nierenfunktion, wohingegen das Nierengewicht bzw. die Nierenmasse von der Prolylhydroxylase-Inhibition unbeeinflusst blieb. Daher könnte die Aktivierung von HIF-1α durch eine pharmakologische Inhibition der Prolylhydroxylase Ziel einer potenziellen therapeutischen Intervention zur Verbesserung der myokardialen Angiogenese bei einer chronischen Nierenerkrankung darstellen und sogar zur Verringerung des Myokardinfarktareales durch Verbesserung der postischämischen myokardialen Kapillarisierung bei einer chronischen Nierenerkrankung beitragen

Analysis of pre-service teachers' flow experience in educational drama practices and the effect of practices on attitudes toward creative drama courses

Aim: The analysis of the flow experience of pre-service teachers in educational drama practices and the effect of the practices on the attitude towards creative drama lessons reveal the purpose of the study. It is of great importance for physical education teachers to use creative drama practices as an effective teaching method in physical education and sports lessons, both in terms of their personal development and professional development.   Method: The study was designed with a pre-test-post-test control group experimental design, one of the true experimental designs, and one of the quantitative research methods. In addition to the demographic information form, the "Flow Experience Scale" and "Attitude Scale towards Creative Drama Lessons" were applied to the participants as measurement tools. The distribution of the participant's demographic information was analyzed by frequency analysis. T-test independent groups analyzed the participants' pre-test and post-test scale scores, and the change in the pre-test and post-test scores of the scales according to demographic information was analyzed by t-test in independent groups and one-way analysis of variance. A regression model was tested to determine the effect of reason on anxiety. Analyses were performed with SPSS 20.0 software at a 95% confidence level. Findings and Conclusions: As a result, there was no significant difference between the attitude scale scores towards flow experience and creative drama course of the students participating in the research according to their age, gender, income level, place of residence, and activity type, and between the pre-tests and post-tests of the scales. However, a significant difference was detected between the pre-test and post-test scores of the flow experience scale anxiety sub-dimension and the flow sub-dimension of the academic achievement variable. In addition, although there was no significant difference in terms of the variables mentioned, it was noted that the flow experience flow and anxiety subscale scores were low. In contrast, the attitude scores towards the creative drama course were high

How to avoid from an ectropion complication by using motor innervation prevention at lower eyelid blepharoplasty surgery

The subciliary incision is the most commonly used approach for lower eyelid blepharoplasty because of the advantages like ease of combining with other periocular and midface rejuvenation techniques. However, the most common reported major complication is lower lid malposition. In this article we described our subciliary dissection technique to protect the motor branches of tarsal orbicularis oculi to avoid from ectropion

Lms Selection Process For Effective Distance Education System In Organizations

 Towards the end of the 20th century, especially development of science and technology brought some innovation to some conceptual area such as education. In society, to build a quality and civilized life, education emerges as a one of the most important actors. Unfortunately, the rights in education of the every person in society may be delayed due to financial problems, physical disabilities, time pressure, geographical distances or any other reasons. Distance learning is a one of the method that provides education for people by eliminating these disadvantages. Since end of the 19th century, distance education has been provided with some methods such as TV, radio, mail and etc. Especially, in the beginning of 21th century; internet is widely used by everybody. New technological environment has brought a new opportunity for distance education. Learning Management System (LMS) is the most important actor of the internet based distance learning that brings together educators and students for training. LMS allows to deliver materials, having assignment and quizzes and other educational activities. Whether educational institutions or organizations that are emphasis on the training of employees can use LMS platform. Every organization has to decide which LMS is suitable for them. Decision makers face to solve this kind of problems because every LMS has different characteristics and different learning process. This study is focused on choosing suitable LMS for organizations by using AHP methods. Two groups of LMS, open source software’s (Moodle and Sakai) and commercial software’s (BlackBoard and Sharepoint LMS), are compared by using selecting criteria’s. These criteria’s are license costs, flexibility, security, user interface and prevalence of use. In the decision process, different weight ratios are used depending on their priority. The findings of this AHP Process are discussed. Keywords: Distance Learning, LMS, AHP, Decision Making Proces

IsVoNet8: A Proposed Deep Learning Model for Classification of Some Fish Species

In the classification of fish, both knowledge and great effort are required to determine the characteristics of fish. Traditionally, however, manual classification of extrinsic characteristics of different fish species has been a difficult and time-consuming process due to their close resemblance to each other. Recently, deep learning methods used in the light of developments in the field ofcomputer vision have facilitated the training of fish image classification models and the recognition of various fish species. In this study, a new convolutional neural network model classifying 8 different belonging to 6 families (Mullidae, Sparidae, Carangidae, Serranidae, Clupeidae, Salmonidae) fish species using deep learning methods was proposed. The species include Clupeonellacultriventris N., Sparus aurata L., Trachurus trachurus L., Mullus barbatus L., Pagrus major T & S., Dicentrarchus labrax L., Mullus surmuletus L. and Oncorhynchus mykiss W. The proposed model (IsVoNet8) is compared with the ResNet50, ResNet101 and VGG16 models. The success accuracies obtained as a result of the comparison are respectively; 98.62% in the IsVoNet8, 91.37% in the ResNet50 model, 86.12% in the ResNet101 model and 97.75% in the VGG16 model. However, it was obtained that the loss rates of ResNet50 0.3646, ResNet101 0.5811, VGG16 0.0696 and with the IsVoNet 0.0568. As a result, it has been observed that the IsVoNet classifies marine fish, which is widely consumed in Türkiye

The effect of phosphorus application on mineral elements concentration of lettuce and onion plants

Marul (Lactuca sativa L.) ve soğan (Allium cepa L.) bitkilerinin gelişimi ve mineral element alımına fosfor (P) uygulamasının etkisini araştırmak üzere Triple süper fosfat (TSP, %42 P2O5) gübresinden 0, 50, 100, 200, 400 mg kg-1 P uygulanmıştır. Marul bitkisinde en yüksek kuru ağırlığa 50 mg kg-1 P düzeyinde ulaşılırken, soğan bitkisinde 200 mg kg-1 P düzeyinde ulaşılmıştır. Artan miktarda uygulanan fosfor ile marul bitkisinin P, Br, Rb konsantrasyonlarının arttığı, Ca, S, Fe, Zn, Mn, Ti, Sr ve Ba konsantrasyonlarının azaldığı belirlenmiştir. Fosfor uygulamasına bağlı olarak bitkilerin Si ve Ni konsantrasyonlarında önemli bir değişim olmamıştır. Artan düzeyde uygulanan fosfora bağlı olarak soğan bitkisinin P, As, Rb, Ba konsantrasyonları artarken Cu, Ti ve Co konsantrasyonları azalmıştır. Fosfor uygulaması, soğan bitkisinin K ve S konsantrasyonunu artırmıştır. Marul bitkisinin K konsantrasyonuna etkisi istatistik olarak önemsiz olurken yüksek P düzeyleri S konsantrasyonunu azaltmıştır. Her iki bitkinin Fe konsantrasyonu P uygulamasına bağlı olarak azalmıştır. En yüksek Br konsantrasyonu her iki bitkide de 400 mg kg-1 P uygulamasında belirlenmiştir. Artan düzeyde uygulanan fosfor ile bitkilerin özellikle bitkiler için mutlak gerekli olmayan mineral konsantrasyonlarının arttığı bu artışın çevre kirliliğinin yanı sıra insan sağlığını olumsuz etkileyebileceği için aşırı fosforlu gübre kullanımından kaçınılması gerektiği sonucuna ulaşılmıştır.In this experiment, effect of phosphorus applications at the levels of 0, 50, 100, 200, 400 mg P kg-1 (as triplesuperphosphate, 42% P2O5) on the growth and mineral composition of lettuce (Lactuca sativa L.) and onion (Allium cepa L.) plants were studied. The highest dry weight of lettuce and onion were found at 50 mg P kg-1 and 200 mg P kg-1 , respectively. Lettuce plant P, Br, Rb concentrations increased and Ca, S, Fe, Zn, Mn, Ti, Sr and Ba concentrations decreased with increasing amounts of phosphorus application and also there is no significant difference on Si and Ni concentrations. On the other hand, the concentration of P, As, Rb and Ba were increased and Cu, Ti and Co decreased by increasing P application in onion plants. Phosphorus application significantly increased K and S concentations of onion. There is no difference on K concentration of lettuce. Sulphur concentration of lettuce was decreased by increasing P levels. Iron concentration of both plants were lower in P applied plants. The highest Br concentration of both plants were determined at the level of 400 mg P kg-1 application. In conclusion, non-essential element concentrations enhanced with increasing application of P. This may cause environmental pollution and also affect human health unfavourably. Hence, it was concluded to avoid excessive P fertilizer using

Recurrent hydatidiform moles: detection of a new mutation in the NLRP7 gene in the family

Hydatidiform moles are the most common type of gestational trophoblastic neoplasia. Hyperproliferative vesicular trophoblasts and imperfect fetal development are abnormal pregnancies, and recurrent hydatidiform moles are rare. Mutations in NLRP7 are responsible for recurrent hydatidiform mole. Genetic heterogeneity has been demonstrated in patients with the NLRP7 mutation. This study presents our case with gravida 11, parity 0, histopathologically diagnosed with six hydatidiform moles and five missed abortion histories at age 35. Karyotype analyses of the unrelated couple were normal. A genetic examination revealed a novel mutation of the NLRP7 gene in the patient, his brother, and his parents. Detecting a new NLRP7 mutation in recurrent hydatidiform moles cases provides further evidence for the predetermined role of NLRP7 mutations in the pathophysiology of recurrent moles hydatidiform. Based on our findings, we hope to contribute to the literature by expanding the spectrum of recurrent pregnancy loss associated with NLRP7 mutations in patients

The effect of inflammatory markers on the CORADS degree and the effects of treatments on RT-PCR test results in COVID-19

Objective: There is still no diagnosis method with high sensitivity and specificity for COVID-19. Patient complaints, real-time reverse transcription-polymerase chain reaction (RT-PCR), inflammatory markers, clinical prognosis, and the degree of involvement in the chest CT, if necessary are evaluated in an effort to make a diagnosis. Delays in diagnosis have led to a rapid spread of the disease. This study aims to evaluate the effectiveness of the inflammatory markers and to determine the follow-up process of the patients by assessing the impact of the treatments administered on RT-PCR test results. Material and methods: Files of 150 patients monitored in the wards with suspected COVID-19 are analyzed retrospectively. Patients were selected among those who underwent laboratory tests, RT-PCR testing and Thoracic CT within the first 24 hours of admission. Patients were divided into 5 groups based on the severity of involvement in Thoracic CT. Inflammatory markers were compared among the groups. Impact of the administered treatments on follow-up RT-PCR test results was evaluated. Results: Studied inflammatory markers were in normal ranges and similar across all CORADS groups. Only the C-Reactive Protein (CRP) and Ferritin levels were showing an increase in accordance with CORADS severity. Mean time to testing negative on RT-PCR was 10 days across all treatment groups. Times to testing negative among patients receiving other treatments were similar. Conclusion: Among the inflammatory markers, CRP and Ferritin values are correlated with CORADS severity. Administered COVID-19 treatments have similar impact on RT-PCR test results

Influence of the gut microbiome on IgE and non-IgE-mediated food allergies

Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- MAY 26-30, 2018 -- Munich, GERMANYWOS: 000441690400204Background: The prevalence of food allergy (FA) in children has been increasing in last decade. Recent studies show changes in gut microbiome with FA. However, whether gut microbiome may differ between IgE and non‐IgE‐mediated FA is not defined. The aim of this study is to examine the intestinal microbiome composition in infants with IgE and non‐IgE‐mediated FA and healthy infants. Method: Infants younger than 1‐year‐old, breastfed and diagnosed with FA by a physician were included in the study. DNA was isolated from stool samples of infants with non‐IgE‐mediated FA (n = 25) and IgE‐mediated FA (n = 11) and healthy infants (n = 7). Whole genome shotgun sequencing was applied to identify the composition of microbial DNA (an average depth of 3.1 ± 0.8 million paired end reads and 0.9 ± 0.2 gigabase pairs). Results: There were compositional differences among 3 different groups. Shannon index was significantly higher in IgE‐mediated FA compared to non‐IgE‐mediated FA group (Kruskal‐Wallis test, P = 0.034). Even though β‐diversity was similar, the Sparse Partial Least Square Discriminant Analysis (sPLS‐DA) demonstrated that there were taxa‐level differences among three groups. In species level, Veillonella parvula was in a significantly higher density in healthy infants compared to IgE and non‐IgE‐mediated FA groups. Rahnella aquatilis and Lactobacillus salivarius were significantly lower and Treponema succinifaciens significantly higher in IgE‐mediated FA group compared to other groups. Additionally, Prevotella sp. oral taxon 299 was significantly lower in non‐IgE‐mediated FA group compared to others. Prevotella sp oral taxon 299 was related to mucus in stool whereas urticaria related species were Olsenall uli, Bactreoides thetaiotaomicron, Klebsiella variiocola, Rahnella aquatilis, Treponema succinfaciens, Ethanoligenens harbinenese. Conclusion: Analysis of microbiome differences in FA patients may aid in the understanding of the disease process. The present data suggest that there are compositional variations mostly in species‐ level among infants with FA and healthy ones. Our results suggest that the gut microbiome has a stronger relationship to IgE‐mediated than non‐IgE‐mediated FA. Further functional analysis of the microbiome may help better understand the changes seen in the gut microbiome in FAs and improve our knowledge in the disease etiopathology.European Academy of Allergy and Clinical Immunolog

Eyelid tumors in dogs: 47 cases retrospective study (2006-2017)

Çalışmada 2006-2017 yılları arasında İstanbul Üniversitesi Veteriner Fakültesi Cerrahi Anabilim Dalı Kliniği’ne göz kapağında kitle şikayeti ile getirilen ve sağaltımları yapılan toplam 47 köpeğe ait göz kapağı tümörleri olguları retrospektif olarak değerlendirildi. Olguların ayrıntılı göz muayenesi yapıldı. Kitlelerin uzaklaştırılmasında V şeklinde eksizyon yeğlenerek, tümör tam katlı olarak bölgeden uzaklaştırıldı. Yapılan histopatolojik inceleme sonucu, meibomian bezlerden köken alan neoplazmaların çoğunlukta olduğu belirlendi. Çalışma sonunda elde edilen veriler ile göz kapağı tümörü oluşumunda ırk predispozisyonu, yaşın ve cinsiyetin etkisi ile en yaygın görülen göz kapağı tümörü belirlenip, kullanılan cerrahi yöntemin rekonstruktif blefaroplastiye gerek kalmadan, kitlelerin uzaklaştırılmasında yeterli olduğu görüldü.In this study, the eyelid tumors and the treatment results of 47 dogs referred to Istanbul University Faculty of Veterinary Medicine Department of Surgery with a complaint of eyelid masses were evaluated retrospectively. Cases underwent detailed ophtalmic examination. A V-shaped excision was performed and the tumor was removed in full-thickness. Histopathological examination revealed that most of the neoplasms originating from the meibomian glands were observed. The most common eyelid tumors and formation of the eyelid tumors with respect to the race predisposition, and effects of age and sex were defined. The surgical method used were sufficient for removal of the masses without the necessity of a reconstructive blepharoplasty