Anal fissürde semptom süresinin botulinum toksini uygulaması sonrası sonuçlara etkisi

Aim: To assess the effect of duration of the symptoms on outcome after botulinum toxin injection in anal fissure treatment. Method: Data of the patients who underwent botulinum toxin injection for chronic anal fissur were reviewed. Patients with a minimum follow-up of 18 months were included. One-hundred IU botulinum toxine was injected in the internal anal sphincter through 4 quadrants. Follow-up was carried out by clinic visits on post-procedure days 7, 15 and 30 and by telephone survey in 3, 6, 12 and 18th months. Refractory symptoms or recurrence were recorded as failure. The relationship between duration of the symptoms and failure was investigated and a cut-off value was determined. Patients were divided into two groups according to duration of the symtoms and outcome was compared with the patients who underwent lateral internal sphincterotomy within the same period. Results: There were 56 patients fulfilling inclusion criteria. Mean age was 33.1±9.4 and 39 (69.6%) patients were female. Presence of the symptoms longer than 8.5 months was predicting treatment failure (Area under curve: 0.721, confidence interval: 0.500-0.942, p=0.037). There were 38 patients in shorter symptoms group, 18 patients in longer sypmtoms group and 32 patients in lateral internal sphincterotomy group. The compelte healing rates after 21 (18-28) months of median survival were 61.1% in longer symptom botulinum toxin group, 94.7% in shorter symptom botulinum toxin group and 96.2% in lateral internal sphincterotomy group (p=0.003). One patient in botulinum toxin groups had local hematoma and one (3.1%) had minor incontinence in lateral internal sphincterotomy group. Conclusion: Botulinum toxin has similar outcome with lateral internal sphincterotomy in patients with shorter suration of sypmtoms. Proper patient selection may contribute to the success of the treatment in chronic anal fissur.Amaç: Anal fissürde semptom süresinin botulinum toksini uygulaması sonrası tedaviye yanıtsızlık ve nüks üzerindeki etkisini araştırmaktır. Yöntem: Mart 2016’dan itibaren anal fissür nedeniyle botulinum toksini uygulanan hastaların verileri incelendi. Takip süresi en az 18 ay olan hastalar çalışmaya dahil edildi. Hastalara internal sfinktere 4 kadrandan 100 IU botulinum toksin-A uygulandı. İşlem sonrası 7, 15, 30. günlerde poliklinik kontrolü ile; 3, 6, 12 ve 18. aylarda telefonla aranarak değerlendirme yapıldı. Botulinum toksini uygulamasına yanıtsızlık ya da nüks başarısızlık olarak kaydedildi. Semptom süresi ve başarısızlık arasındaki ilişki alıcı işletim karakteristiği analizi ile araştırıldı ve bulunan kesme değerine göre iki gruba ayrılan botulinum toksini uygulanan hastalar aynı dönemde lateral internal sfinkterotomi ile tedavi edilmiş hastalarla karşılaştırıldı. Bulgular: Botulinum toksini uygulanan 56 hastada ortalama yaş 33,1±9,4 idi. Hastaların 39’u (%69,6) kadındı. Ortalama semptom süresi 8,5±7,4 aydı. Ortanca 21 (18-28) aylık izlem süresinde 47 (%83,9) hastada iyileşme oldu. Semptom süresinin 8,5 aydan uzun olması tedavi başarısızlığını öngörmekteydi (Eğri altındaki alan: 0,721, güven aralığı: 0,500-0,942, p=0,037). Hastalar semptom süresine göre 2 gruba ayrılarak aynı dönemde lateral internal sfinkterotomi yapılan 32 hasta ile sonuçları karşılaştırıldı. İyileşme oranları semptom süresi uzun olan botulinum toksini grubunda %61,1, semptom süresi kısa olan botulinum toksini grubunda %94,7 ve lateral internal sfinkterotomi grubunda %96,2 idi (p=0,003). Botulinum toksini uygulaması sonrası 1 hastada lokal hematom, lateral internal sfinkterotomi uygulaması sonrası 1 (%3,1) hastada minör inkontinens görüldü. Sonuç: Anal fissür tedavisinde botulinum toksini uygulaması semptom süresi kısa olan hastalarda lateral internal sfinkterotomi ile benzer etkinliktedir. Botulinum toksini uygulamasında hasta seçimi tedavi başarısını etkileyebilir

Factors associated with postoperative chronic pain and recurrence after laparoscopic total extraperitoneal inguinal hernia repair

Objective: To assess the risk factors for chronic pain and recurrence after laparoscopic total extraperitoneal (TEP) inguinal hernia repair. Methods: Data of the patients who underwent laparoscopic TEP repair were analyzed. Clinical and surgical characteristics, including learning curve, mesh weight, the pore size of the mesh, use of mesh fixation, and fixation methods, were assessed. Fixation by absorbable or nonabsorbable tackers was performed in all procedures except for self-fixating meshes. Mesh brands were tiered into groups regarding pore size and weight. Operative time was defined as the duration between skin incision and dressing. The minimum follow-up was 24 months. Postoperative chronic pain was defined as moderate to severe groin pain, which was accepted as a Visual Analog score ≥3 longer than three months. Pain and recurrence were evaluated at 1 and 6 weeks in clinic visits and at 3, 12, and 24 months by telephone questionnaires. The occurrence of a fascial defect in physical examination or ultrasound was defined as recurrence. Results: Three-hundred and eighty-two procedures were included. Postoperative chronic pain was seen in 31 (8.1%) patients and was higher with micropore mesh (p=0.004), mesh fixation (p=0.002), fixation with titanium tacks (p<0.001) and at first 50 cases (p=0.043). Fifteen (3.9%) patients had a recurrence. Older age (p=0.046), prolonged operative time (p=0.040), body mass index (BMI) (p=0.008) and learning curve (p=0.034) were significantly associated with higher recurrence rate. In multivariate analysis pore size [Odds ratio (OR): 2.911, 95% confidence interval (CI): 1.153-7.351, p=0.024] and fixation with titanium tacks (OR: 8.776, 95% CI: 4.040-14.893, p=0.004) were independent risk factors for chronic pain; BMI (OR: 1.307-95% CI:1.138-1.501, p<0.001) was the only independent risk factor for recurrence. Conclusion: The outcome of laparoscopic TEP repair is related to the technic as well as patient-based factors. Titanium tacks and micropore meshes increase postoperative pain risk without any benefit on recurrence. Patients with higher BMI have an increased recurrence risk

Clinical Experience for Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) in Five Patients. Dermatomal Evaluation and Application of Different Volumes: A Case Series and Review of Literature

Thoracoabdominal nerves block through perichondrial approach (TAPA) is a novel block and provides abdominal analgesia. TAPA block targets the both anterior and the lateral branches of the thoracoabdominal nerves. Modified-TAPA (M-TAPA) was defined due to the need for blocking certain dermatomes depending on the surgical incision sites. In the literature, the knowledge about the efficiency and dermatomal coverage of M-TAPA is limited. In this case series, we want to report our experiences with this issue

An evaluation of the reliability of the neutrophil-tolymphocyte ratio in patients with acute cholecystitis undergoing laparoscopic surgery

Introduction: Acute cholecystitis is observed quite commonly in emergency surgery clinics and parameters are needed for diagnosis and treatment. The aim of this study was to determine whether the neutrophil-tolymphocyte ratio (NLR) is of benefi in the diagnosis of acute cholecystitis. Materials and Methods: A retrospective evaluation of patients who were hospitalized between January 2014 and February 2018 for the treatment of acute cholecystitis was conducted. The blood tests and radiological tests of the patients were evaluated. The NLR was calculated and compared with the clinical and laboratory values of the patients. Results: A total of 185 patients were identifid, comprising 102 (55.1%) females and 83 (44.9%) males with a mean age of 51.5±15.9 years. The mean leukocyte count was 11.6±3.6 109/L and the mean C-reactive protein (CRP) value was 37±76.4 mg/L. Overall, 90 (48.6%) patients had normal leukocyte values and 59 (31.8%) patients had normal CRP values. In 20 (10.8%) patients with an NLR of approximately 1, only 1 (5%) was aged >60 years and all of the remaining patients were <45 years of age. In 53 (28.6%) patients, the NLR was determined to be approximately 2, and the NLR value was ≥3 in 112 (60.5%) patients. Conclusion: Awareness of an increased NLR may be benefiial in the diagnosis of patients with acute cholecystitis

Can traditional fermented food products protect mothers against lactational mastitis

Background/Objective: Various dietary factors, including the daily food intake during pregnancy and lactation can play a role in the development of lactational mastitis (LM). To investigate the effect of the most commonly consumed fermented foods (FF) during pregnancy and lactation in Turkey and other factors described in the literature regarding childbirth and breastfeeding on the development of LM. Materials and Methods: The study included 607 volunteers in the lactational period, of whom 303 had LM and 304 had no mastitis event. The data on sociodemographics, childbirth, and breastfeeding, and the consumption frequency of six types of FF were collected through a face-to-face questionnaire. Results: The variables significantly and independently associated with LM were birth week (odds ratio [OR] = 80.83, 95% confidence interval [CI]: 1.12-1.94), birth weight (OR = 0.63, CI: 1.24-1.79), time to breastfeeding after birth (OR = 0.79, CI: 1.62-2.31), breastfeeding length (OR = 0.12, CI: 2.25-2.78), breast preference (OR = 0.13, CI: 2.83-3.42), use of cream on nipples (OR = 0.81, CI: 1.31-1.97), use of oral probiotics (OR = 0.29, CI: 1.86-2.92), and receiving breastfeeding education from an expert (OR = 0.22, CI: 1.22-2.34). According to the multinominal logistic regression analysis, the daily consumption of kefir (OR = 0.69, CI: 1.18-2.22), homemade yogurt (OR = 0.78, CI: 1.14-1.87), conventional yogurt (OR = 0.81, CI: 1.24-2.46), boza (OR = 0.79, CI: 2.19-2.99), tarhana (OR = 0.52, CI: 2.47-2.81), and pickles (OR = 0.22, CI: 1.22-2.34) significantly reduced the risk of LM development. The diversity of consumed FF was also found to be protective against LM (OR = 0.34, CI: 1.34-2.35). Conclusion: Kefir, homemade and conventional yogurt, boza, tarhana, and pickles can protect breastfeeding mothers and also reduce the risk of LM development

Self-reported medication adherence in differentiated thyroid cancer survivors: Role of illness perception and medication beliefs

Background To investigate medication adherence (MA) to Levothyroxine in differentiated thyroid cancer survivors and analyze the related factors for nonadherence. Methods The Medication Adherence Report Scale (MARS), Hospital Anxiety and Depression Scale (HAD), Brief Illness Perception Questionnaire (B-IPQ), and Beliefs about Medicines Questionnaire (BMQ) were used to assess MA. Results Nonadherence was reported in 77 of 197 patients (39.1%). Socioeconomic status and education levels were found to be significantly related to MA. The HAD scores, all items of B-IPQ, and BMQ were associated with MA and showed a correlation with the MARS scores. The primary predictors of MA were greater confidence in treatment modality (odds ratio [OR]: 0.48, 95% confidence interval (CI): 0.37-0.63) and greater belief that the medication had minimal risk of harm (OR: 3.35, 95% CI: 1.50-7.49). Conclusions Special attention should be paid to educational programs for differentiated thyroid carcinoma patients concerning the effectiveness and low risk of harm of medication in order to improve MA

Gall bladder polyps: Our experience in a tertiary referral centre

Aim: An increasing number of patients are undergoing surgical treatment for gallbladder polyps (GPs). As there is still controversy on the subject, it remains unclear whether GPs are the precursors of gallbladder tumors. The aim of this study was to examine the clinicopathological features of patients who had undergone cholecystectomy in our clinic for the treatment of gallbladder polyps. Material and Methods: A retrospective review was made of the clinicopathological data of patients who underwent cholecystectomy, selected from a group of 2048 patients, who received treatment between 2014-2018. Results: A total of 79 (3.8%) patients were identified, comprising 50 (63.2%) females and 29 (36.8%) males with a mean age of 43 years (range, 22-81 years). During pre-operative ultrasonography, 60 (75.9%) patients were detected with a single polyp and 19 (23.1%) patients had multiple polyps. When postoperative histology was evaluated, 70 (88.6%) patients had cholesterol polyps, 2 (2.5%) patients had gallbladder stones, 5 (6.3%) patients had papillary adenomas without dysplasia and 1 (1.2%) patient had papillary adenoma with dysplasia, while 1 (1.2%) of patient had gallbladder adenocarcinoma. Conclusion: According to the results of this study, as gallbladder polyps may be pre-cancerous or cancerous lesions, patients diagnosed with GP should be followed up closely with surgical treatment applied when necessary

Can traditional fermented food products protect mothers against lactational mastitis (Retraction of vol 15, Pg 163, 2020)

Breastfeeding Medicineofficially retracts the published article entitled, ‘‘Can Traditional Fermented Food ProductsProtect Mothers Against Lactational Mastitis,’’ by Pelin Basım and Yaşar Özdenkaya (Breastfeed Med 2020;15(3):163–169(doi: 10.1089/bfm.2019.0261)

Giant sacral schwannoma causing bilateral hydronephrosis: Case report and review of the literature

BACKGROUND: Giant sacral schwannomas are very rare, and less than 1%-5% of spinal schwannomas are found in the sacral region. These frequently grow to considerable size because of permissive anatomic location and benign, slow growth of tumor. They can be unnoticed before reaching a huge size.CASE DESCRIPTION: We report a rare case of a giant sacral schwannoma in a 46-year-old man. The patient presented with difficulty in passing urine, episodic constipation, and swelling of the right lower extremity for 6 months. Magnetic resonance imaging revealed 160 x 110 x 110 mm encapsulated heterogenous solid mass originated from left S1 spinal nerve extending into the pelvis and abdomen. Sigmoid colon and rectum were displaced to the right side, and bladder was displaced anteriorly. Left side of the S1 and S2 vertebral bodies, left S1 and S2 neural foramen were also eroded. It also compressed ureters causing bilateral hydronephrosis. The patient underwent a 2-stage procedure in which complete resection was achieved.CONCLUSIONS: We report the second case of a completely resected giant sacral schwannoma with bilateral hydronephrosis in the literature. Performing a 2-stage procedure is important in giant sacral schwannomas. Morbidity can be minimized, and extent of resection can be maximized with the help of combined anterior/posterior approach

Problems with the median arcuate ligament should be recognized before surgery; Its importance in pancreaticoduodenectomy

Background: Celiac artery stenosis (CAS) is a not a rare finding in the general population. The median arcuate ligament (MAL) is a fibrous arch that unites the diaphragmatic crura on either side of the aortic hiatus and, while it normally passes cranial to the origin of the celiac truncus, a low-lying ligament may lead to compression of the celiac artery and is the one of the major causes of CAS. Case Report: In this paper, we present a patient with a mass in the gastric bulbus who was diagnosed with celiac artery stenosis during the pancreaticoduodenec- tomy (PD). MAL was the cause of the celiac artery ste- nosis, determined based on the findings of preoperative computed tomography (CT). Conclusion: Although CAS is usually asymptomatic due to the collateral blood supply, it may be associated with potentially disastrous results due to ischemia of the upper abdominal organs as a result of disruption of the collateral pathways. It is especially important to recognize the presence of CAS and its etiology before interventional procedures. With the increasing use of multidetector computed tomography (MDCT), it be- comes essential for radiologists to be aware of this entity and the cross-sectional findings