From the Group of Twenty to the Group of Two: The Need for Harmonizing Derivatives Regulation Between the United States and the European Union

Wireless Sensor Networks are often deployed in great numbers spanning large, sometimes hard to reach and hostile, areas with the aim of monitoring environmental conditions through the use of different sensors. Due to decreasing costs of ownership (e.g. non-proprietary protocols), recent advances in processor, radio, and memory technologies and the engineering of increasingly smaller sensing devices, the availability and area of application for wireless sensor networks have steadily been increasing. Sigma Technology Development Stockholm AB raised the question as to whether a wireless sensor network, running an open-source operating system and communicating over IPv6, could be used in the field of smart autonomous irrigation? The company also required a proof-of-concept system for demonstration purposes and to identify if the design choices made were suitable for an actual implementation. There are numerous of design decisions that have to be made when constructing an irrigation system: the back-end set-up, which irrigation algorithms to use, what hardware to choose and how to communicate? This thesis therefore focuses on the overall system design of a wireless sensor network in the field of irrigation and highlights the trade-offs being made and their pros and cons. Two improvements related to the existing technology and the proof-of-concept system are presented in this thesis. Firstly, the recommendation to use clustered self-healing routing despite claimed power consumption issues. Secondly, a new technique to minimize power consumption, by dynamically changing the sleep interval on the sensor nodes with the help of weather data. Furthermore, the proof-of-concept system is constructed and analysed to assess whether the system design choices made are valid for a real-life deployment.Trådlösa sensor nätverk används för att övervaka lokala miljöförändringar med hjälp av olika sorters sensorer. På grund av nedåtgående driftkostnader (ökad tillgänglighet av open-source mjukvara) och framsteg inom processor-, radio-, och datorminnesteknolgi har både tillgängligheten och användningsområdena för trådlösa sensornätverk stadigt ökat. Sigma Technology Development AB ställde frågan huruvida ett trådlöst sensornätverk, som använder sig av ett open-source operativsystem och kommunicerar över IPv6, kunde användas inom smart konstbevattning? Företaget ville även att ett proof-ofconcept system utvecklades för demonstration samt för att kunna avgöra om de designval som gjorts är lämpliga att använda i en verklig implementation. Det finns en mängd designval som måste göras när man konstruerar ett bevattningsystem: back-end lösningen, vilka bevattningsalogritmer som ska användas, vilken hårdvara som ska användas samt hur kommunikationen mellan noderna ska upprättas? Det här examensarbetet fokuserar därför på den övergripande systemdesigen av ett trådlöst sensornätverk inom konstbevattning, utvärderar och avgör vilka kompromisser som måste göras samt för- och nackdelarna med dessa val. Examensarbetet presenterar vidare två förbättringar på det utvecklade konceptsystemet som inte heller finns på marknanden. Först rekommenderas användandet av robusta självläkande routing protokoll trots påstådda energiförbrukningsproblem. Sedan föreslås även en teknik som minimerar energiåtgången genom att dynamiskt ändra hur länge sensornoden befinner sig i ’sleep mode’, detta med hjälp av insamlad väderdata. Slutligen så konstrueras och analyseras proof-of-concept systemet för att utvärdera om dessa designval är lämpliga för en implementering i det verkliga livet

Multivariate data analysis applied to MRS and MRI studies of aging and spinal cord injury

Magnetic resonance can be used for non-invasive studies of the body without the use of ionizing radiation. Magnetic resonance imaging and magnetic resonance spectroscopy have proven to be valuable utilities for research in life sciences. This thesis deals with magnetic resonance investigations of the central nervous system in vivo and is based on four studies. In studies I-III in vivo proton magnetic resonance spectroscopy data were acquired in three animal models. These models were designed to monitor Alzheimer’s disease, spinal cord injury and premature aging. We wanted to quantify and evaluate the differences in metabolite levels in diseased animals in comparison with controls. In study IV, resting-state functional magnetic resonance imaging was applied to investigate young and elderly human subjects. Three different pre-processing procedures were also evaluated. Furthermore, in this thesis we aimed to explore how data acquired with magnetic resonance spectroscopy and functional magnetic resonance imaging can be extracted and analyzed using model free and model driven multivariate data analyses. The linear multivariate data analysis methods principal components analysis and partial least squares projections to latent structures were applied to magnetic resonance spectroscopy data acquired in rodents. Independent component analysis was applied to the resting-state functional magnetic resonance imaging data acquired in human subjects. Group differences in brain metabolites between diseased and control animals were observed and reported in study I-III. By applying the method partial least squares projections to latent structures to all detected metabolites, we were able to develop models that could differentiate the diseased rodents from the normal controls and evaluate the sensitivity and specificity of the models. In study IV we investigated the effects of preprocessing prior to independent component analysis. We found that global signal removal can enhance anti-correlation in resting-state functional connectivity networks. We also found that normal brain aging can lead to significant changes in functional connectivity

Future water management in Swedish private gardens. : practical advice in case of excess and deficit of water, using Simrishamn's and Mölndal's municipalities as a reference-point.

Vi är två studenter som tillsammans har skrivit om hur de klimatförändringar, som vi redan märker av och som hotar att förvärras framöver, kan påverka vattensituationen i Sverige med tillfälligt överskott eller brist på vatten. Vi har utgått från två politiska direktiv, EU:s ramdirektiv för vattenpolitik som från EU via regeringen berör vattenhanteringen i Sveriges kommuner samt EU:s grönbok, ”Anpassning till klimatförändringarna i Europa – tänkbara EU-åtgärder”. De två huvudproblem som kan uppstå i samband med förändrade nederbördsförhållanden är dels en överskottssituation orsakad av kraftig nederbörd och dels torka sommartid orsakad av uteblivet regn. För att se vad som görs på kommunnivå med dessa EU-direktiv har vi valt att titta närmare på Simrishamns kommun i sydöstra Sverige, en kommun som sommartid kan få problem med torka, samt Mölndals kommun i västra Sverige, där kraftig nederbörd har orsakat översvämningar. Syftet med arbetet är att lyfta fram hur de politiska ramarna kan komma att påverka privata trädgårdsägare och hur kommuninvånarna kan medverka till att uppfylla de politiska direktiven genom att i trädgården ta till olika konkreta åtgärder. Exempel på detta kan vara att ha torktåliga växter eller dammar för att samla dagvatten, istället för att vattna med dricksvatten i trädgården om torka råder. Därför presenterar vi i arbetet två förslag på trädgårdar som anpassats efter de extrema nederbördssituationer som förväntas att bli allt vanligare. I förslagen beskrivs markförberedelser, växtval samt lösningar på hur dagvatten kan ledas bort eller tas tillvara

In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

<p>Abstract</p> <p>Background</p> <p>Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and <it>myo-</it>inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human β-amyloid precursor protein (APP) and mutated human presenilin 1 (PS1). Consequently, the APP/PS1 mouse model reflects important features of the neurochemical profile in humans. <it>In vivo </it>magnetic resonance spectroscopy (¹H-MRS) was performed in fronto-parietal cortex and hippocampus (ctx/hipp) and in striatum (str). Metabolites were quantified using the LCModel and the final analysis was done using multivariate data analysis. The aim of this study was to investigate if multivariate data analysis could detect changes in the pattern of the metabolic profile after donepezil treatment.</p> <p>Results</p> <p>Significant differences were observed in the metabolic pattern of APP/PS1 mice in both str and ctx/hipp before and after donepezil treatment using multivariate data analysis, evidencing a significant treatment effect. A treatment effect was also seen in wild type (wt) mice in str. A significant decrease in the metabolic ratio taurine/creatine (Tau/tCr) was related to donepezil treatment (p < 0.05) in APP/PS1 mice in both brain regions. Furthermore, a significant influence on the choline/creatine (tCho/tCr) level was observed in treated APP/PS1 mice compared to untreated in str (p = 0.011). Finally, there was an increase in glutamate/creatine (Glu/tCr) in str in wt mice treated with donepezil.</p> <p>Conclusion</p> <p>Multivariate data analysis can detect changes in the metabolic profile in APP/PS1 mice after donepezil treatment. Effects on several metabolites that are measurable <it>in vivo </it>using MR spectroscopy were observed. Changes in Tau/tCr and tCho/tCr could possibly be related to changed cholinergic activity caused by donepezil treatment.</p

Probing the mechanisms underpinning recovery in post‐surgical patients with cervical radiculopathy using Bayesian networks

Background Rehabilitation approaches should be based on an understanding of the mechanisms underpinning functional recovery. Yet, the mediators that drive an improvement in post‐surgical pain‐related disability in individuals with cervical radiculopathy (CR) are unknown. The aim of the present study is to use Bayesian networks (BN) to learn the probabilistic relationships between physical and psychological factors, and pain-related disability in CR. Methods We analysed a prospective cohort dataset of 201 post‐surgical individuals with CR. In all, 15 variables were used to build a BN model: age, sex, neck muscle endurance, neck range of motion, neck proprioception, hand grip strength, self-efficacy, catastrophizing, depression, somatic perception, arm pain intensity, neck pain intensity and disability. Results A one point increase in a change of self‐efficacy at 6 months was associated with a 0.09 point decrease in a change in disability at 12 months (t = −64.09, p < .001). Two pathways led to a change in disability: a direct path leading from a change in self-efficacy at 6 months to disability, and an indirect path which was mediated by neck and arm pain intensity changes at 6 and 12 months. Conclusions This is the first study to apply BN modelling to understand the mechanisms of recovery in post‐surgical individuals with CR. Improvements in pain‐related disability was directly and indirectly driven by changes in self‐efficacy levels. The present study provides potentially modifiable mediators that could be the target of future intervention trials. BN models could increase the precision of treatment and outcome assessment of individuals with CR. Significance Using Bayesian Network modelling, we found that changes in self-efficacy levels at 6-month post-surgery directly and indirectly influenced the change in disability in individuals with CR. A mechanistic understanding of recovery provides potentially modifiable mediators that could be the target of future intervention trials

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of its DUB domain and related genetic variants remain unclear. We aimed to study the functional effects of A20 DUB-domain alterations in immune cells and understand its link to SLE pathogenesis. Methods: CRISPR/Cas9 was used to generate human U937 monocytes with A20 DUB-inactivating C103A knock-in (KI) mutation. Whole genome RNA-sequencing was used to identify differentially expressed genes between WT and C103A KI cells. Functional studies were performed in A20 C103A U937 cells and in immune cells from A20 C103A mice and genotyped healthy individuals with A20 DUB polymorphism rs2230926. Neutrophil extracellular trap (NET) formation was addressed ex vivo in neutrophils from A20 C103A mice and SLE-patients with rs2230926. Results: Genetic disruption of A20 DUB domain in human and murine myeloid cells did not give rise to enhanced NF-κB signalling. Instead, cells with C103A mutation or rs2230926 polymorphism presented an upregulated expression of PADI4, an enzyme regulating protein citrullination and NET formation, two key mechanisms in autoimmune pathology. A20 C103A cells exhibited enhanced protein citrullination and extracellular trap formation, which could be suppressed by selective PAD4 inhibition. Moreover, SLE-patients with rs2230926 showed increased NETs and increased frequency of autoantibodies to citrullinated epitopes. Conclusions: We propose that genetic alterations disrupting the A20 DUB domain mediate increased susceptibility to SLE through the upregulation of PADI4 with resultant protein citrullination and extracellular trap formation

The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation

Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by the identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterized by a selective reduction in the glomerular filtration of 5–30 kDa molecules, such as cystatin C, compared to the filtration of small molecules <1 kDa dominating the glomerular filtrate, for example water, urea and creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterized by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.publishedVersio

A new research agenda for managing socio-cultural integration

Post-acquisition socio-cultural integration has received increasing attention from both scholars and practitioners since the early 1990s. During the past decade, research has increasingly focused on emotions and identity in mergers and acquisitions. This chapter introduces the reader to the vibrant research field and its relevance. This section sets the scene for the book, which provides a deeper understanding of how emotions—both positive and negative—as well as values and identity enable a deeper socio-cultural integration after a merger or acquisition, and how leadership plays a crucial role in making it all happen. This chapter also highlights how the Nordic approach to post-acquisition socio-cultural integration refers to a large community of Nordic academics focusing on the softer social and human side of acquisition, often relying on a huge variety of qualitative methods, and to Nordic companies that are not afraid of adopting a more collaborative approach to post-acquisition integration

Uniform Atmospheric Retrieval Analysis of Ultracool Dwarfs I : Characterizing Benchmarks, Gl570D and HD3651B

Michael Line, et al, 'UNIFORM ATMOSPHERIC RETRIEVAL ANALYSIS OF ULTRACOOL DWARFS. I. CHARACTERIZING BENCHMARKS, Gl 570D AND HD 3651B', The Astrophysical Journal, Vol. 802 (2), July 2015, doi: https://doi.org/10.1088/0004-637X/807/2/183, published by IOP.Interpreting the spectra of brown dwarfs is key to determining the fundamental physical and chemical processes occurring in their atmospheres. Powerful Bayesian atmospheric retrieval tools have recently been applied to both exoplanet and brown dwarf spectra to tease out the thermal structures and molecular abundances to understand those processes. In this manuscript we develop a significantly upgraded retrieval method and apply it to the SpeX spectral library data of two benchmark late T-dwarfs, Gl570D and HD3651B, to establish the validity of our upgraded forward model parameterization and Bayesian estimator. Our retrieved metallicities, gravities, and effective temperature are consistent with the metallicity and presumed ages of the systems. We add the carbon-to-oxygen ratio as a new dimension to benchmark systems and find good agreement between carbon-to-oxygens ratio derived in the brown dwarfs and the host stars. Furthermore, we have for the first time unambiguously determined the presence of ammonia in the low-resolution spectra of these two late T-dwarfs. We also show that the retrieved results are not significantly impacted by the possible presence of clouds, though some quantities are significantly impacted by uncertainties in photometry. This investigation represents a watershed study in establishing the utility of atmospheric retrieval approaches on brown dwarf spectra.Peer reviewedFinal Published versio