Kırım Kongo kanamalı ateşine H. pylori varlığının etkisi

Background and Aims: Crimean Congo hemorrhagic fever can cause a fa- tal hemorrhagic syndrome. We aimed to investigate whether the presence of Helicobacter pylori increases the bleeding or severity of Crimean Congo hemorrhagic fever. Materials and Methods: Forty-two patients with Crime- an Congo hemorrhagic fever who had dyspepsia and were hospitalized be- tween April 2009 and July 2009 were included in the study. The patients were divided into two groups according to their fecal Helicobacter pylori an- tigen positivity. Clinical and laboratory severity criteria for Crimean Congo hemorrhagic fever were investigated in both groups. Results: We could not find any difference between the two groups with regard to severity as de- fined by clinical and laboratory criteria. Conclusion: This is the first study in the literature investigating the role of Helicobacter pylori in the severity of Crimean Congo hemorrhagic fever from a country in which both Crimean Congo hemorrhagic fever and Helicobacter pylori are endemic. Further stud- ies including a larger number of Crimean Congo hemorrhagic fever patients are necessary to recommend Helicobacter pylori screening and eradication in Crimean Congo hemorrhagic fever.Giriş ve Amaç: Kırım Kongo kanamalı ateşi ölümcül hemorajik bir sendro- ma neden olabilir. Bu çalışmada Helicobacter pylori varlığının Kırım Kongo kanamalı ateşi hastalığının şiddeti ya da kanama üzerine etkisinin olup olma- dığını araştırdık. Gereç ve Yöntem: Kırım Kongo kanamalı ateşi nedeniyle Nisan 2009-Temmuz 2009 arası hospitalize edilen kırk iki dispeptik hasta çalışmaya dahil edildi. Hastalar fekal Helicobacter pylori antijeni pozitifliği durumuna göre iki gruba ayrıldı. Her iki grupta Kırım Kongo kanamalı ate- şi'nin klinik ve labaratuvar olarak şiddet kriterleri değerlendirildi. Bulgular: Klinik ve laboratuvar kriterleri açısından iki grup arasında Kırım Kongo ka- namalı ateşi hastalık şiddeti açısından farklılık saptanmadı. Sonuç: Bu çalış- ma Helicobacter pylori'nin Kırım Kongo kanamalı ateşi'nin şiddeti üzerine etkisini araştıran ilk çalışma olması ve hem Helicobacter pylori hem de Kırım Kongo kanamalı ateşi'nin endemik olduğu bir bölgeden yapılması nedeniyle önemlidir. Ancak Kırım Kongo kanamalı ateşi hastalarında rutin Helicobac- ter pylori taranması ve eradikasyonunun önerilebilmesi için daha geniş vaka sayılı çalışmalara ihtiyaç vardır

Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi

Background: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the more post-ERCP complications decrease. Aims: To compare the relaxant effects of ataciguat (a novel soluble guanylyl cyclase activator) and zaprinast (an inhibitor of phosphodiesterase 5) on sheep SO in vitro, thus testing whether they can be used during ERCP. Study Design: Animal experimentation. Methods: Sheep SO rings were placed in tissue baths and their isometric tension to ataciguat and zaprinast were tested. We also tested their isometric tension against ataciguat in the presence of 1H-(1,2,4) oxadiazole (4,3-a) quinoxalin- 1-one (ODQ) which is a soluble guanylyl cyclase inhibitor. Results: Ataciguat and zaprinast both triggered concentration addicted relaxation on sheep SO rings (p=0.0018, p=0.0025 respectively) but the relaxation of the ataciguat was significantly greater than that of zaprinast at all concentrations (p=0.0024). It was observed that decreased relaxation responses were initiated by ataciguat in the presence of ODQ (p=0.0012). Conclusion: Ataciguat and zaprinast both have relaxing effects on sphincter of Oddi, although that of zaprinast is lower. We believe that ataciguat and zaprinast can be used in ERCP procedures in order to relax the sphincter of Oddi and thus can be used locally in order to decrease complications