Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study

<p>Abstract</p> <p>Background</p> <p>Chemical pleurodesis is widely recommended in the treatment of refractory pleural effusion or pulmonary air leak of different etiologies. Although several agents have been used, many questions have remained unanswered about their toxicity. Talc is the most commonly used agent for the treatment, with rare, serious complications reported. Oxytetracycline pleurodesis in clinical practice has been described in a few studies, but literature reveals no experimental studies using this agent. We performed a prospective, randomized, observer-blinded, controlled study to evaluate the changes in lung histology and systemic response to pleurodesis with oxytetracycline and talc in acute and subacute phases in a rat model.</p> <p>Methods</p> <p>Forty-two male albino Wistar rats were divided into three groups and 3 subgroups with 7 animals in each. Group 1 was given oxytetracycline, 35 mg/kg; Group 2 was given talc slurry, 60 mg/kg in 0.5 mL saline solution, and Group 3 was given only 0.5 mL saline intrapleurally. In subgroups "a" the nimls were sacrificed at the postoperative 72^ndhour and, in subgroups "b", on the postoperative day 7. The surfaces were graded by microscopic examination.</p> <p>Results</p> <p>Oxytetracycline produced alveolar collapse, hemorrhage, edema, inflammation at the postoperative 72^ndhour and hemorrhage on the postoperative day 7, while talc produced significant edema, inflammation, proliferation, fibrosis at the postoperative 72^ndhour and hemorrhage, edema, inflammation, proliferation, and fibrosis on the postoperative day 7 (p < 0,0042). Talc produced significant edema compared to oxytetracycline on the postoperative day 7. On contralateral side, oxytetracycline and talc produced significant hemorrhage on the postoperative day 7 (p < 0.0042).</p> <p>Conclusions</p> <p>Both agents were shown to produce pulmonary lesions. In acute phase, the pulmonary side effects of oxytetracycline were more pronounced, whereas the side effects of talc were prolonged to subacute phase. We propose that the occasional side effects in humans may be related to these changes as were observed in our rat model, and like talc, oxytetracycline must be used cautiously in patients with limited respiratory function.</p

Acute Eosinophilic Pneumonia with Respiratory Failure Induced by Synthetic Cannabinoid Inhalation

Background: In recent days, synthetic cannabinoid derivatives have become life threatening for young people. Here, we want to share a case of acute eosinophilic pneumonia triggered by inhalation of synthetic cannabinoid, new side effects of which are being detected day by day. Case Report: A 21-year-old male, who had no history of pulmonary diseases, was admitted to the clinic with shortness of breath. His oxygen saturation was measured as 85-86% in room air. Common irregular ground-glass opacities were observed in thorax radiology. His peripheral blood eosinophil count was 1100 cell/mm³ with a leukocyte differential of 12%. Sputum eosinophilia was also observed. The patient was diagnosed with acute eosinophilic pneumonia in terms of current clinical, radiological and laboratory findings. Rapid remission was achieved with corticosteroid therapy. Conclusion: This is the first reported case of acute eosinophilic pneumonia induced by synthetic cannabinoid inhalation

Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method

Yurekli, Aslan/0000-0003-2812-2133WOS: 000473301300002PubMed: 31233167Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. The objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. Methods: We introduced a novel technique to remove perichondrium using cryosurgery. Hypertrophic scars obtained with conventional surgery and cryosurgery were studied in a left-right comparison method. Comparative parameters included the histological structure of the scars and structural changes in the cartilage just beneath the scarring. Results: Cryosurgery produced similar scars in comparison to conventional surgery. Although statistically not significant (p = 0.16), the histological findings of cartilage damage were lower in the cryosurgery group (six out of 21) compared to the established model (10 out of 20). Conclusions: This study suggests that cryotherapy can be used for removal of perichondrium.Gulhane School of Medicine Research Grant committeeThis study was financially supported by the Gulhane School of Medicine Research Grant committee and was conducted at the Animal Research Laboratory of the same institution

Sezaryen sırasında insidental olarak saptanan over tümörü

Overin müsinöz tümörleri, seröz over tümörlerinden sonra en sık karşımızı çıkan epitelyal over tümörlerindendir. Gebelik esnasında over tümörleri ile nadir olarak karşılaşmaktayız. Olguların bir kısmı, rutin antenatal takipler sırasında ultrasonografi ve fizik muayene ile tanı alırken, diğer bir kısmı ise insidental olarak sezaryen sırasında karşımıza çıkmaktadır. Bu olguda, 30 yaşında nullipar hastada, sezaryen ile doğumu gerçekleştirildiği esnada insidental olarak tespit edilen over tümöründen söz edilmiştir