Optimization of the therapeutic approach to patients with sarcoma: Delphi Consensus

Delphi consensus; Sarcoma treatment; Panel of expertsConsenso Delphi; Tratamiento del sarcoma; Panel de expertosConsens Delphi; Tractament del sarcoma; Panell d'expertsSoft tissue sarcomas (STS) constitute a heterogeneous group of rare solid tumors associated with significant morbidity and mortality. The evaluation and treatment of STS require a multidisciplinary team with extensive experience in the management of these types of tumors. National and international clinical practice guidelines for STS do not always provide answers to a great many situations that specialists have to contend with in their everyday practice. This consensus provides a series of specific recommendations based on available scientific evidence and the experience of a group of experts to assist in decision-making by all the specialists involved in the management of STS

People Detection and Tracking Using LIDAR Sensors

Special Issue Robotics in Spain 2019[EN] The tracking of people is an indispensable capacity in almost any robotic application. A relevant case is the @home robotic competitions, where the service robots have to demonstrate that they possess certain skills that allow them to interact with the environment and the people who occupy it; for example, receiving the people who knock at the door and attending them as appropriate. Many of these skills are based on the ability to detect and track a person. It is a challenging problem, particularly when implemented using low-definition sensors, such as Laser Imaging Detection and Ranging (LIDAR) sensors, in environments where there are several people interacting. This work describes a solution based on a single LIDAR sensor to maintain a continuous identification of a person in time and space. The system described is based on the People Tracker package, aka PeTra, which uses a convolutional neural network to identify person legs in complex environments. A new feature has been included within the system to correlate over time the people location estimates by using a Kalman filter. To validate the solution, a set of experiments have been carried out in a test environment certified by the European Robotic League.SIJunta de Castilla y León (LE028P17)Comunidad de Madrid (RoboCity2030-Fase 3

Effect of Maternal Dietary Condensed Tannins from Sainfoin (Onobrychis viciifolia) on Gut Health and Antioxidant-Immune Crosstalk in Suckling Lambs

Ewes fed sainfoin (a source of condensed tannins "CT") may influence the homeostasis of the gastrointestinal tract of suckling lambs. This study investigated the effects of CT from sainfoin in the maternal diet on plasma fructosamine, faecal coccidian excretion, and gene expression of immune and antioxidant markers in jejunum and ileum of suckling lambs. Twelve Rasa Aragonesa lambs with their dams were selected. The maternal diet was based on fresh sainfoin (SAINFOIN, n = 6) and sainfoin + polyethylene-glycol (SAINFOIN + PEG, as a CT-binder, n = 6) plus a daily supplement of 200 g barley in both groups. A lower percentage of lambs that shed more than 10 oocysts/g faeces was observed in SAINFOIN compared to the SAINFOIN + PEG group (p = 0.07). Jejunal gene expression of transforming growth factor-β1, tumour necrosis factor-α, and glutathione peroxidase (GPX) 1 and 4 were lower in the SAINFOIN group (p < 0.05). In contrast, ileal catalase and GPX2 expression were increased in the SAINFOIN group (p < 0.05). Overall, the results suggest that the presence of CT in the dams' diets has a positive effect on reducing excreted coccidian oocysts and favours antioxidant-immune crosstalk at gut level in suckling lambs.This research was funded by the Ministry of Science, Innovation and Universities of Spain and the European Regional Development Funds, grant number INIA RTA2017-00008-C02-01 and 02

A vaccine based on a mutant transferrin binding protein B of Haemophilus parasuis induces a strong T-helper 2 response and bacterial clearance after experimental infection

9 p.This study aimed to characterize the type of immune response induced by an experimental vaccine based on a mutant Haemophilus parasuis transferrin binding protein (Tbp) B (Y167A) defective in its ability to bind porcine transferrin. Clinical and pathological signs, bacterial clearance, antibody response and the cytokine profile in alveolar macrophages and spleen after the vaccination and challenge of twenty-two colostrum-deprived pigs with 108 CFU of H. parasuis were analysed. Pigs vaccinated with Y167A were compared to those vaccinated with native TbpB (nTbpB), those treated with a commercial bacterin (CB) against Glässer's disease, those unvaccinated challenged (CH) and those unvaccinated unchallenged (UNCH) pigs. The rectal temperatures of Y167A pigs resembled those of UNCH pigs and were significantly lower than those of the nTbpB, CB and CH animals. A major reduction in pathological changes of the challenged pigs was observed in the Y167A group. H. parasuis was cleared from 88.9% of the samples from Y167A pigs versus 60.0% and 55.6% from those of the CB and nTbpB groups, respectively. The antibody response elicited by Y167A by ELISA was notably higher than that observed for nTbpB and CB pigs and was capable of preventing the expression and secretion of IL-8. The expression of IL-4 and IL-5, which were associated with the specific antibody levels, suggests that the main mechanism of protection conferred by Y167A vaccine is based on a strong T-helper 2 responseS

Matemática aplicada a la arquitectura y aprendizaje significativo.

Trabajo presentado en el 9º Encuentro de Docentes de Matemática en Carreras al Arquitectura, Urbanismo y Diseño de Universidades Nacionales del MERCOSUR. San Miguel de Tucumán, Argentina. 2015Este trabajo tiene por objetivo compartir una experiencia educativa en la que estamos abocados integrantes de la Cátedra de Matemática IB de la FAUD (UNC), y que surge de la permanente búsqueda para lograr que la enseñanza de la matemática se convierta en un aprendizaje significativo para alumnos de primer año de la carrera de Arquitectura en condición de recursantes: esta experiencia "desarrollada desde el año pasado y en el corriente-, consiste en la elaboración de una Guía Teórico Práctica que se soporta en la idea de trabajar sobre una Matemática Aplicada a la Arquitectura. En esta Guía pretendemos materializar el espíritu con el que se viene trabajando desde hace? años, esto es que los contenidos de la Asignatura ?en tanto conjunto de conocimientos- son de carácter instrumental y, por lo tanto, conducentes a una aplicación plena con el resto de las asignaturas de la Carrera. Así, pensamos que la Geometría" elemental y analítica-, más la realización de cálculos numéricos o algebraicos y, por último, la modelización de situaciones, son herramientas fundamentales para abordar el objeto arquitectónico. Entonces, para que los contenidos de la Asignatura puedan apropiarse de manera efectiva, los conocimientos que se imparten y refieren deben anclarse a estructuras previas que le otorguen sentido: para eso -y según Vigotski-, para que el aprendizaje se produzca deben existir instrumentos mediadores y herramientas que funcionen como puentes entre el tema de estudio y los que aprenden, más aún cuando los sujetos de aprendizaje ya han cursado previamente los contenidos fundamentales de una Asignatura y en la cual han fracasado en su primer intento. En este sentido, la Guía intenta ser un instrumento posibilitador de ese aprendizaje significativo a través de cada tema recorrido, en la medida en que las actividades propuestas parten de la premisa básica de concebir una Matemática Aplicada a la Arquitectura.http://www.fau.unt.edu.ar/novedades/9o-encuentro-de-docentes-de-matematica-en-carreras-de-arquitectura-y-disenoFil: Simes, Juan José. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Almada, Pablo. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Ávila, María Cristina. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Álvarez, Nora. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Gareca, Claudia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Martín, Adriana. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaMatemática Aplicad

Síndrome febril asociado a sífilis y bacteriemia por Clostridium limosum

Se informa el caso de un paciente masculino de 41 años con fiebre de origen desconocido (FOD) e insuficiencia aórtica, quien recibió dos ciclos independientes de antibiótico con persistencia de su cuadro febril, y a quien luego de múltiples estudios intrahospitalarios, se le diagnosticó bacteriemia por Clostridium limosum y sífilis latente versus tardía. Los estudios realizados no evidenciaron la presencia de enfermedad del tejido conectivo ni procesos tumorales. Las bacteriemias por gérmenes del género Clostridium no son comunes y cuando se presentan, se asocian con procesos neoplásicos, especialmente de colon. Las infecciones por C. limosum son aún más raras; en la literatura sólo se ha informado en cuatro casos (tres humanos y un animal), y en ninguno se ha relacionado con FOD. Por otra parte, aunque la sífilis era una causa frecuente de FOD, actualmente es poco común por la facilidad en su diagnóstico. En este caso no fue posible determinar cuál de los dos diagnósticos fue el origen de la FOD, ya que se inició tratamiento simultáneamente para ambos con resolución clínica. En conclusión, en este caso se presenta una posible nueva causa de FOD: bacteriemia por C. limosum, y se recuerda a la sífilis como uno de los posibles diagnósticos diferenciales de FOD.Presentación de casos429-43

Tracking People in a Mobile Robot From 2D LIDAR Scans Using Full Convolutional Neural Networks for Security in Cluttered Environments

[EN] Tracking people has many applications, such as security or safe use of robots. Many onboard systems are based on Laser Imaging Detection and Ranging (LIDAR) sensors. Tracking peoples' legs using only information from a 2D LIDAR scanner in a mobile robot is a challenging problem because many legs can be present in an indoor environment, there are frequent occlusions and self-occlusions, many items in the environment such as table legs or columns could resemble legs as a result of the limited information provided by two-dimensional LIDAR usually mounted at knee height in mobile robots, etc. On the other hand, LIDAR sensors are affordable in terms of the acquisition price and processing requirements. In this article, we describe a tool named PeTra based on an off-line trained full Convolutional Neural Network capable of tracking pairs of legs in a cluttered environment. We describe the characteristics of the system proposed and evaluate its accuracy using a dataset from a public repository. Results show that PeTra provides better accuracy than Leg Detector (LD), the standard solution for Robot Operating System (ROS)-based robots.SIJunta de Castilla y León (LE028P17)Instituto Nacional de Cibersegurida

Combination of searches for invisible decays of the Higgs boson using 139 fb−1 of proton-proton collision data at √s = 13 TeV collected with the ATLAS experiment

Artículo escrito por un alto número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMMany extensions of the Standard Model predict the production of dark matter particles at the LHC. Sufficiently light dark matter particles may be produced in decays of the Higgs boson that would appear invisible to the detector. This Letter presents a statistical combination of searches for H→invisible decays where multiple production modes of the Standard Model Higgs boson are considered. These searches are performed with the ATLAS detector using 139 fb−1 of proton–proton collisions at a centre–of–mass energy of [Formula presented] at the LHC. In combination with the results at [Formula presented] and [Formula presented], an upper limit on the H→invisible branching ratio of 0.107 (0.077) at the 95% confidence level is observed (expected). These results are also interpreted in the context of models where the 125 GeV Higgs boson acts as a portal to dark matter, and limits are set on the scattering cross-section of weakly interacting massive particles and nucleonsWe acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MEYS CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DSI/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TENMAK, Türkiye; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; PRIMUS 21/SCI/017 and UNCE SCI/013, Czech Republic; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; NCN and NAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdo

Search for Higgs bosons decaying into new spin-0 or spin-1 particles in four-lepton final states with the ATLAS detector with 139 fb-1 of pp collision data at root √s=13 TeV

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMSearches are conducted for new spin-0 or spin-1 bosons using events where a Higgs boson with mass 125 GeV decays into four leptons (ℓ = e, μ). This decay is presumed to occur via an intermediate state which contains two on-shell, promptly decaying bosons: H → XX/ZX → 4ℓ, where the new boson X has a mass between 1 and 60 GeV. The search uses pp collision data collected with the ATLAS detector at the LHC with an integrated luminosity of 139 fb−1 at a centre-of-mass energy s = 13 TeV. The data are found to be consistent with Standard Model expectations. Limits are set on fiducial cross sections and on the branching ratio of the Higgs boson to decay into XX/ZX, improving those from previous publications by a factor between two and four. Limits are also set on mixing parameters relevant in extensions of the Standard Model containing a dark sector where X is interpreted to be a dark boso

Production of ϒ(nS) mesons in Pb + Pb and pp collisions at 5.02 TeV

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA measurement of the production of vector bottomonium states, ϒ(1S), ϒ(2S), and ϒ(3S), in Pb + Pb and pp collisions at a center-of-mass energy per nucleon pair of 5.02 TeV is presented. The data correspond to integrated luminosities of 1.38 nb-1 of Pb + Pb data collected in 2018, 0.44 nb-1 of Pb + Pb data collected in 2015, and 0.26 fb-1 of pp data collected in 2017 by the ATLAS detector at the Large Hadron Collider. The measurements are performed in the dimuon decay channel for transverse momentum pμμT < 30 GeV, absolute rapidity |yμμ| < 1.5, and Pb + Pb event centrality 0-80%. The production rates of the three bottomonium states in Pb + Pb collisions are compared with those in pp collisions to extract the nuclear modification factors as functions of event centrality, pμμT, and |yμμ|. In addition, the suppression of the excited states relative to the ground state is studied. The results are compared with theoretical model calculationsWe thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MEYS CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DSI/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TENMAK, Türkiye; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; PRIMUS 21/SCI/017 and UNCE SCI/013, Czech Republic; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; NCN and NAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN; the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK), and BNL (USA); the Tier-2 facilities worldwide; and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref