AME - Asteroseismology Made Easy. Estimating stellar properties by use of scaled models

We present a new method to obtain stellar properties for stars exhibiting solar-like oscillations in an easy, fast, and transparent way. The method, called Asteroseismology Made Easy (AME), can determine stellar masses, mean-densities, radii, and surface gravities, as well as estimate ages. In this writing we present AME as a visual and powerful tool which could be useful; in particular in the light of the large number of exoplanets being found. AME consists of a set of figures from which the stellar parameters are deduced. These figures are made from a grid of stellar evolutionary models that cover masses ranging from 0.7 Msun to 1.6 Msun in steps of 0.1 Msun and metallicities in the interval -0.3 dex <= [Fe/H] <= +0.3 dex in increments of 0.1 dex. The stellar evolutionary models are computed using the Modules for Experiments in Stellar Astrophysics (MESA) code with simple input physics. We have compared the results from AME with results for three groups of stars; stars with radii determined from interferometry (and measured parallaxes), stars with radii determined from measurements of their parallaxes (and calculated angular diameters), and stars with results based on the modelling of their individual oscillation frequencies. We find that a comparison of the radii from interferometry to those from AME yield a weighted mean of the fractional differences of just 2%. This is also the level of deviation that we find when we compare the parallax-based radii to the radii determined from AME. The comparison between independently determined stellar parameters and those found using AME show that our method can provide reliable stellar masses, radii, and ages, with median uncertainties in the order of 4%, 2%, and 25% respectively.Comment: 18 pages, 25 figures. To be published in Astronomy & Astrophysic

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately regulated to result in more complex morphogenetic events, such as tubular sprouting, fusion, and network formation. We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts. The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks. These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration. Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells

Screening for Abdominal Aortic Aneurysm among Patients Referred to the Vascular Laboratory is Cost-effective

AbstractScreening for abdominal aortic aneurysm (AAA) in high-risk groups has been recommended based on a high prevalence of disease, while being questioned due to a high frequency of co-morbidities and inferior life-expectancy. We evaluated the long-term outcome and the cost-effectiveness of selective AAA screening among patients referred to the vascular laboratory for arterial examination.MethodsA total of 5924 patients, referred to the vascular laboratory of a university hospital, were screened for AAA with ultrasound (definition: ∅≥30mm), 1993–2005. Outcome data were gathered through hospital records and the national population registry. A Markov model was used for health–economic evaluation.ResultsAn AAA was detected in 181 patients (mean age 72.8 years), of whom 21.5% underwent elective repair (perioperative mortality 5.1%) after 7.5 years of follow-up. Four of six patients diagnosed with AAA rupture were operated upon. Relative 5-year survival compared with the general Swedish population, controlled for age and sex, was 80.4% (95% confidence interval (CI): 70.8–88.8). The cost-effectiveness was robust in base-case (11 084 Euro/life year gained) and in sensitivity analyses of prevalence, cost and survival.ConclusionsPatients in whom AAA was detected at selective screening had inferior long-term survival and were operated on less frequently, compared with AAA patients described in previous studies. Yet, selective screening at the vascular laboratory was cost-effective

Correction to: Economic evaluation of AbobotulinumtoxinA vs OnabotulinumtoxinA in real-life clinical management of cervical dystonia.

[This corrects the article DOI: 10.1186/s40734-020-0083-0.]

Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in interferon-competent cells than the isolate having truncated NSs ORF

<p>Abstract</p> <p>Background</p> <p>The competitiveness of two Tula hantavirus (TULV) isolates, TULV/Lodz and TULV/Moravia, was evaluated in interferon (IFN) -competent and IFN-deficient cells. The two isolates differ in the length of the open reading frame (ORF) encoding the nonstructural protein NSs, which has previously been shown to inhibit IFN response in infected cells.</p> <p>Results</p> <p>In IFN-deficient Vero E6 cells both TULV isolates survived equally well. In contrast, in IFN-competent MRC5 cells TULV/Lodz isolate, that possesses the NSs ORF for the full-length protein of 90 aa, survived for more consequent passages than TULV/Moravia isolate, which contains the ORF for truncated NSs protein (66–67 aa).</p> <p>Conclusion</p> <p>Our data show that expression of a full-length NSs protein is beneficial for the virus survival and competitiveness in IFN-competent cells and not essential in IFN-deficient cells. These results suggest that the N-terminal aa residues are important for the full activity of the NSs protein.</p

Limits on surface gravities of Kepler planet-candidate host stars from non-detection of solar-like oscillations

We present a novel method for estimating lower-limit surface gravities log g of Kepler targets whose data do not allow the detection of solar-like oscillations. The method is tested using an ensemble of solar-type stars observed in the context of the Kepler Asteroseismic Science Consortium. We then proceed to estimate lower-limit log g for a cohort of Kepler solar-type planet-candidate host stars with no detected oscillations. Limits on fundamental stellar properties, as provided by this work, are likely to be useful in the characterization of the corresponding candidate planetary systems. Furthermore, an important byproduct of the current work is the confirmation that amplitudes of solar-like oscillations are suppressed in stars with increased levels of surface magnetic activity.Comment: Accepted for publication in ApJ; 35 pages, 10 figures, 5 table

Ages and fundamental properties of Kepler exoplanet host stars from asteroseismology

We present a study of 33 {\it Kepler} planet-candidate host stars for which asteroseismic observations have sufficiently high signal-to-noise ratio to allow extraction of individual pulsation frequencies. We implement a new Bayesian scheme that is flexible in its input to process individual oscillation frequencies, combinations of them, and average asteroseismic parameters, and derive robust fundamental properties for these targets. Applying this scheme to grids of evolutionary models yields stellar properties with median statistical uncertainties of 1.2\% (radius), 1.7\% (density), 3.3\% (mass), 4.4\% (distance), and 14\% (age), making this the exoplanet host-star sample with the most precise and uniformly determined fundamental parameters to date. We assess the systematics from changes in the solar abundances and mixing-length parameter, showing that they are smaller than the statistical errors. We also determine the stellar properties with three other fitting algorithms and explore the systematics arising from using different evolution and pulsation codes, resulting in 1\% in density and radius, and 2\% and 7\% in mass and age, respectively. We confirm previous findings of the initial helium abundance being a source of systematics comparable to our statistical uncertainties, and discuss future prospects for constraining this parameter by combining asteroseismology and data from space missions. Finally we compare our derived properties with those obtained using the global average asteroseismic observables along with effective temperature and metallicity, finding an excellent level of agreement. Owing to selection effects, our results show that the majority of the high signal-to-noise ratio asteroseismic {\it Kepler} host stars are older than the Sun.Comment: 25 pages, 17 figures, MNRAS accepte

The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation

Aims: We present 11 high-precision photometric transit observations of the transiting super-Earth planet GJ1214b. Combining these data with observations from other authors, we investigate the ephemeris for possible signs of transit timing variations (TTVs) using a Bayesian approach. Methods: The observations were obtained using telescope-defocusing techniques, and achieve a high precision with random errors in the photometry as low as 1mmag per point. To investigate the possibility of TTVs in the light curve, we calculate the overall probability of a TTV signal using Bayesian methods. Results: The observations are used to determine the photometric parameters and the physical properties of the GJ1214 system. Our results are in good agreement with published values. Individual times of mid-transit are measured with uncertainties as low as 10s, allowing us to reduce the uncertainty in the orbital period by a factor of two. Conclusions: A Bayesian analysis reveals that it is highly improbable that the observed transit times is explained by TTV, when compared with the simpler alternative of a linear ephemeris.Comment: Submitted to A&

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

<p>Abstract</p> <p>Background</p> <p>The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been observed in neuropsychiatric and neurodegenerative disorders as well as in patients with affective disorders. The purpose of the present study was to investigate if skin derived human fibroblasts are useful for studies of expression of enzymes in the KP.</p> <p>Methods</p> <p>Fibroblast cultures were established from cutaneous biopsies taken from the arm of consenting volunteers. Such cultures were subsequently treated with interferon (IFN)-γ 200 U/ml and/or tumor necrosis factor (TNF)-α, 100 U/ml for 48 hours in serum-free medium. Levels of transcripts encoding different enzymes were determined by real-time PCR and levels of kynurenic acid (KYNA) were determined by HPLC.</p> <p>Results</p> <p>At base-line all cultures harbored detectable levels of transcripts encoding KP enzymes, albeit with considerable variation across individuals. Following cytokine treatment, considerable changes in many of the transcripts investigated were observed. For example, increases in the abundance of transcripts encoding indoleamine 2,3-dioxygenase, kynureninase or 3-hydroxyanthranilic acid oxygenase and decreases in the levels of transcripts encoding tryptophan 2,3-dioxygenase, kynurenine aminotransferases or quinolinic acid phosphoribosyltransferase were observed following IFN-γ and TNF-α treatment. Finally, the fibroblast cultures released detectable levels of KYNA in the cell culture medium at base-line conditions, which were increased after IFN-γ, but not TNF-α, treatments.</p> <p>Conclusions</p> <p>All of the investigated genes encoding KP enzymes were expressed in human fibroblasts. Expression of many of these appeared to be regulated in response to cytokine treatment as previously reported for other cell types. Fibroblast cultures, thus, appear to be useful for studies of disease-related abnormalities in the kynurenine pathway of tryptophan degradation.</p

Asteroseismic determination of obliquities of the exoplanet systems Kepler-50 and Kepler-65

Results on the obliquity of exoplanet host stars -- the angle between the stellar spin axis and the planetary orbital axis -- provide important diagnostic information for theories describing planetary formation. Here we present the first application of asteroseismology to the problem of stellar obliquity determination in systems with transiting planets and Sun-like host stars. We consider two systems observed by the NASA Kepler Mission which have multiple transiting small (super-Earth sized) planets: the previously reported Kepler-50 and a new system, Kepler-65, whose planets we validate in this paper. Both stars show rich spectra of solar-like oscillations. From the asteroseismic analysis we find that each host has its rotation axis nearly perpendicular to the line of sight with the sines of the angles constrained at the 1-sigma level to lie above 0.97 and 0.91, respectively. We use statistical arguments to show that coplanar orbits are favoured in both systems, and that the orientations of the planetary orbits and the stellar rotation axis are correlated.Comment: Accepted for publication in ApJ; 46 pages, 11 figure