Berardinelli-Seip Syndrome

We have reported two cases of Berardinelli-syndrome in a family which is a rare autosomal recessive disorder of the adipose tissue, originally described by Berardinelli and Seip, has been reported in approximately 120 patients of various ethnic origins. Assuming that only 1 in 4 patients is reported.Patients present with acanthosis nigricans (dark velvety pigmentation of the skin) in the axilla, neck or groin, severe insulin resistance, high levels of serum insulin and serum triglycerides.The other clinical features consist of enlarged hands, feet and prominent mandible (acromegaloid features), increased sweating, umbilical hernia and lytic lesions (bone appear to be eaten-up on X-rays) in long bones of the upper and lower extremities (arms, forearm, hands, thigh, calf, legs and feet) such as humerus, femur, etc. Hepatomegaly from fatty liver is almost universal and may ultimately lead to cirrhosis. Splenomegaly is common. Nearly all patients have a prominent umbilicus or frank umbilical hernia. Females present with enlarged clitoris, increased body hair, absence of or irregular menstrual cycles, and polycystic ovaries (enlarged ovaries). Only a few affected women have had successful pregnancies, whereas affected men have normal fertilit

Influence of a neck compression collar on cerebrovascular and autonomic function in men and women

Objective Neck compression collars have been proposed to reduce injury to the brain caused by head impacts. Our objective was to test if compression of the carotid artery affected the baroreflex and influenced blood pressure control. Methods Cerebrovascular and autonomic responses of healthy young men and women (n = 8 each) to paced deep breathing, Valsalva, and 70o head-up tilt with or without use of a Q-collar were determined. Continuous measurements of heart rate, beat-to-beat blood pressure, transcranial Doppler, and end-tidal gases were obtained. Heart rate variability was measured during supine rest and head-up tilt. Carotid artery and jugular vein cross-sectional area were measured at end-inhalation and end-exhalation using cross-sectional ultrasound images at diastole. Results Wearing the collar reduced carotid cross-sectional area (CSA; P = 0.022; η2 = 0.03) and increased jugular CSA (P = 0.001; η 2 = 0.30). In both men and women, wearing the collar increased systolic blood pressure during Valsalva (P0.05), and there were no effects of the collar on cerebrovascular function, hemodynamics, cardiovagal baroreceptor sensitivity, or heart rate variability (P>0.05) during upright tilt. Conclusion Use of the Q-collar compresses both the jugular vein and carotid artery influencing sympathetic nerve activity in both men and women while influencing brain blood flow in women.York University Librarie

Data Processing from Bank Cheques by Utilising Split Attribute Character Analysis and Multi Branch Network Forest Classifier Techniques

Bank cheques are primarily used for conducting financial transactions, resulting in their substantial daily processing volumes worldwide. The automation of the whole process of recognising and verifying cheques has the potential to significantly reduce both the time and expenditures associated with cheque execution. The field of automatic bank cheque processing system is now gaining prominence in the realm of computer vision, image processing, pattern recognition, machine learning, and deep learning. The study places particular emphasis on the sequential processes involved in the automated bank Cheque processing system, including picture capture, pre-processing, and extraction and identification. This article provides an overview of the sequential processes included in the automated data extraction system. This research aims to propose strategies for the automated processing of bank cheque images via the use of Split Attribute character analysis and Multi branch network forest classifier. The study indicates that the recommended technique demonstrates satisfactory performance by achieving high levels of accuracy, precision, recall, and F score