"Go hard or go home!" : Eine qualitative Untersuchung zur Bedeutung diverser Körper(-formen) für die Anerken- nung junger Männer innerhalb der Fitnessszene

Der gegenwärtige Trend der Körpermodellierung hat in den letzten Jahren ebenso stetig Veränderungen erfahren wie das kommerzielle Fitnessstudio als ein anerkannter Ort der Artikulation moderner Körper- lichkeit. Dies zeigt sich insbesondere an den gestiegenen Ansprüchen hinsichtlich gesellschaftlich akzep- tierter Körperideale. Dabei bedingt das Sporttreiben im Fitnessstudio positive wie auch negative Erfah- rungen, die an das Aussehen und die sportliche Leistung gebunden sind. Hiervon ausgehend nimmt die vorliegende Studie an der Schnittstelle von Sportwissenschaften und Geschlechterforschung die Frage in den Blick, welche Bedeutung diverse Körper(-formen) für die Anerkennung junger Männer innerhalb der Fitnessszene haben. Hierbei werden zum einen positive Anerkennungserfahrungen basierend auf der richtigen Selbstinszenierung sowie der sportlichen Leistung deutlich. Zum anderen werden Abhän- gigkeiten zwischen Hierarchien unter Männern, körperbezogenen Diskriminierungstendenzen und der selbstbestimmten Teilnahme am körpermodellierenden Sport sichtbar. The current trend in body shaping has undergone continuous changes in recent years just as the com- mercial gym has as a recognized place for the articulation of modern corporality. This especially be- comes apparent in the increased standards regarding socially accepted body ideals. Engaging in sport activities at the gym thus induces positive as well as negative experiences which are tied to appearance and athletic performance. From here, the study at hand considers the question – at the point of inter- section of sport science and gender studies – which meaning diverse body forms have for the recogni- tion of young men in the context of fitness. In this process, positive experiences of recognition based on appropriate self-fashioning as well as athletic performance become evident, on the one hand. On the other hand, dependencies between body-related tendencies of discrimination, body dissatisfaction and self-determined participation in body-modulating sport become apparent

ベトナム産 Kaempferia marginata 及び Crinum asiaticum の化学成分とNO生産抑制活性に関する研究

富山大学・富医薬博甲第423号・Kiep Minh Do・2023/03/23公表論文1.Do KM, Kodama T, Shin MK, Nu LHT, Nguyen HM, Dang SV, Shiokawa KI, Hayakawa Y, Morita H. Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities. Phytochemistry. 2022 Apr;196:113109. doi: 10.1016/j.phytochem.2022.113109. Epub 2022 Jan 25. PMID: 35091214.2.Do KM, Kodama T, Nguyen HM, Ikumi N, Soeda C, Shiokawa KI, Morita H. Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities. Phytochemistry. 2023 Jan;205:113510. doi: 10.1016/j.phytochem.2022.113510. Epub 2022 Nov 12. PMID: 36379318.3.Do KM, Shin MK, Kodama T, Win NN, Prema P, Nguyen HM, Hayakawa Y, Morita H. Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation. Planta Med. 2022 Sep;88(11):913-920. doi: 10.1055/a-1585-5877. Epub 2021 Sep 2. PMID: 34474490.富山大

Cereal processing at Early Neolithic Göbekli Tepe, southeastern Turkey

We analyze the processing of cereals and its role at Early Neolithic Göbekli Tepe, southeastern Anatolia (10th / 9th millennium BC), a site that has aroused much debate in archaeological discourse

Epigenotype-genotype-phenotype correlations in SETD1A and SETD2 chromatin disorders

Germline pathogenic variants in two genes encoding the lysine-specific histone methyltransferase genes SETD1A and SETD2 are associated with neurodevelopmental disorders (NDDs) characterised by developmental delay and congenital anomalies. The SETD1A and SETD2 gene products play a critical role in chromatin-mediated regulation of gene expression. Specific methylation episignatures have been detected for a range of chromatin gene-related NDDs and have impacted clinical practice by improving interpretation of variant pathogenicity. To investigate if SETD1A and/or SETD2-related NDDs are associated with a detectable episignature, we undertook targeted genome-wide methylation profiling of > 2 M CpGs using a next generation sequencing based assay. Comparison of methylation profiles in patients with SETD1A variants (n = 6) did not reveal evidence of a strong methylation episignature. Review of the clinical and genetic features of SETD2 patient group revealed that, as reported previously, there were phenotypic differences between patients with truncating mutations (n = 4, Luscan-Lumish syndrome; MIM:616831) and those with missense codon 1740 variants (p.Arg1740Trp (n = 4) and p.Arg1740Gln (n = 2)). Both SETD2 subgroups demonstrated a methylation episignature which was characterised by hypomethylation and hypermethylation events respectively. Within the codon 1740 subgroup, both the methylation changes and clinical phenotype were more severe in those with p.Arg1740Trp variants. We also noted that two of 10 cases with a SETD2-NDD had developed a neoplasm. These findings reveal novel epigenotype-genotype–phenotype correlations in SETD2-NDDs and predict a gain-of-function mechanism for SETD2 codon 1740 pathogenic variants