17 research outputs found
In Situ Quantification of Experimental Ice Accretion on Tree Crowns Using Terrestrial Laser Scanning
THE EFFECTS OF PHYSICAL ATTRACTIVENESS ON JOB-RELATED OUTCOMES: A META-ANALYSIS OF EXPERIMENTAL STUDIES
Daxx Upregulation within the Cytoplasm of Reovirus-Infected Cells Is Mediated by Interferon and Contributes to Apoptosis
Religious service attendance and decline in pulmonary function in a high-functioning elderly cohort
Molecular and cellular analysis of orange plants infected with Huanglongbing (citrus greening disease)
Evidence of behavior-based utilization by the Asian citrus psyllid of a combination of UV and green or yellow wavelengths
Intrinsic tumour suppression
Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically