Antimikrobno djelovanje derivata 3-hidroksi-2-metilen-3-fenilpropionske kiseline

Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.Iz različitih aromatskih aldehida i aktiviranih vinil derivata sintetizirano je dvadeset Baylis-Hillmanovih adukata, različito supstituiranih derivata 3-hidroksi-2-metilen-3-fenilpropionske kiseline. Ispitano je njihovo antimikrobno djelovanje in vitro metodom serijskih razrjeđenja. Većina ispitivanih spojeva pokazala je snažno antibakterijsko i antifungalno djelovanje. Jednostavni sintetski postupak iz jeftinih sirovina i snažno antimikrobno djelovanje pružaju vodeće spojeve za daljnju modifikaciju, koji mogu dovesti do ljekovitih tvari pogodnih za terapijsku primjenu

Nonhalogenated organic molecules from Laurencia algae

The marine red algae of the genus Laurencia have produced more 700 secondary metabolites and exhibited high molecular diversity and intriguing bioactivity. Since the halogenated structures have been comprehensively reviewed previously, this review, covering up to the end of 2012, mainly focuses on the source, structure elucidation, and bioactivity of nonhalogenated organic molecules from Laurencia spp. as well as the relationship between nonhalogenated and halogenated products. Overall, 173 new or new naturally occurring compounds with 58 skeletons, mainly including sesquiterpenes, diterpenes, triterpenes, and C15-acetogenins, are described.The marine red algae of the genus Laurencia have produced more 700 secondary metabolites and exhibited high molecular diversity and intriguing bioactivity. Since the halogenated structures have been comprehensively reviewed previously, this review, covering up to the end of 2012, mainly focuses on the source, structure elucidation, and bioactivity of nonhalogenated organic molecules from Laurencia spp. as well as the relationship between nonhalogenated and halogenated products. Overall, 173 new or new naturally occurring compounds with 58 skeletons, mainly including sesquiterpenes, diterpenes, triterpenes, and C-15-acetogenins, are described

Synthesis and Characterization of Boron Trifluoride Doped High Performance Polyaniline

We report simple synthesis of boron trifluoride (BF3) doped defect free high performance polyaniline (HPPANI) in two step method. Firstly, HPPANI was prepared via self-stabilization dispersion polymerization method in a heterogeneous reaction medium. Second step involves doping of emeraldine base form of HPPANI with boron trifluoride under reduced vacuum. The resultants BF3 doped HPPANI have been well characterized by using UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermogravimetry. The spectroscopic data indicated that the interaction between HPPANI and BF3.Thermogravimetry studies revealed that the BF3 doping improved the thermal stability of defects free PANI