Confederate Veterans Association Catawba Camp No. 278 Records - Accession 579

This collection consists of photocopies of records related to the Confederate Veterans Association Catawba Camp No. 278. The majority of the records consist of minutes, but also includes membership lists, newspaper clippings, and resolutions. Also included in the collection are Catawba Camp flag and two ribbons. The Catawba Camp was organized in 1893 and was based in Rock Hill, SC with Colonel Cadwallader Jones as the Commander.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1693/thumbnail.jp

Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses.

Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune responses. Immune responses in survivors of Ebola virus (EBOV) and Sudan virus (SUDV) infections have provided the most insight, with T cell responses as well as detailed antibody responses having been characterized. Immune responses to Marburg virus (MARV), however, remain almost entirely uncharacterized. We report that immune responses in MARV survivors share characteristics with EBOV and SUDV infections but have some distinct differences. MARV survivors developed multivariate CD4(+) T cell responses but limited CD8(+) T cell responses, more in keeping with SUDV survivors than EBOV survivors. In stark contrast to SUDV survivors, rare neutralizing antibody responses in MARV survivors diminished rapidly after the outbreak. These results warrant serious consideration for any vaccine or therapeutic that seeks to be broadly protective, as different filoviruses may require different immune responses to achieve immunity

Feasibility of a mental practice intervention in stroke patients in nursing homes; a process evaluation

<p>Abstract</p> <p>Background</p> <p>Within a multi-centre randomised controlled trial in three nursing homes, a process evaluation of a mental practice intervention was conducted. The main aims were to determine if the intervention was performed according to the framework and to describe the therapists' and participants' experiences with and opinions on the intervention.</p> <p>Methods</p> <p>The six week mental practice intervention was given by physiotherapists and occupational therapists in the rehabilitation teams and consisted of four phases: explanation of imagery, teaching patients how to use imagery, using imagery as part of therapy, and facilitating the patient in using it alone and for new tasks. It had a mandatory and an optional part. Data were collected by means of registration forms, pre structured patient files, patient logs and self-administered questionnaires.</p> <p>Results</p> <p>A total of 14 therapists and 18 patients with stroke in the sub acute phase of recovery were involved. Response rates differed per assessment (range 57-93%). Two patients dropped out of the study (total n = 16). The mandatory part of the intervention was given to 11 of 16 patients: 13 received the prescribed amount of mental practice and 12 practiced unguided outside of therapy. The facilitating techniques of the optional part of the framework were partly used. Therapists were moderately positive about the use of imagery in this specific sample. Although it was more difficult for some patients to generate images than others, all patients were positive about the intervention and reported perceived short term benefits from mental practice.</p> <p>Conclusions</p> <p>The intervention was less feasible than we hoped. Implementing a complex therapy delivered by existing multi-professional teams to a vulnerable population with a complex pathology poses many challenges.</p

Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

BACKGROUND: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. METHODS: We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). Patients were recruited from hospitals in the UK as part of the UK DNA Lacunar Stroke studies 1 and 2 and from collaborators within the International Stroke Genetics Consortium. Cases and controls were stratified by ancestry and two meta-analyses were done: a European ancestry analysis, and a transethnic analysis that included all ancestry groups. We also did a multi-trait analysis of GWAS, in a joint analysis with a study of cerebral white matter hyperintensities (an aetiologically related radiological trait), to find additional genetic associations. We did a transcriptome-wide association study (TWAS) to detect genes for which expression is associated with lacunar stroke; identified significantly enriched pathways using multi-marker analysis of genomic annotation; and evaluated cardiovascular risk factors causally associated with the disease using mendelian randomisation. FINDINGS: Our meta-analysis comprised studies from Europe, the USA, and Australia, including 7338 cases and 254 798 controls, of which 2987 cases (matched with 29 540 controls) were confirmed using MRI. Five loci (ICA1L-WDR12-CARF-NBEAL1, ULK4, SPI1-SLC39A13-PSMC3-RAPSN, ZCCHC14, ZBTB14-EPB41L3) were found to be associated with lacunar stroke in the European or transethnic meta-analyses. A further seven loci (SLC25A44-PMF1-BGLAP, LOX-ZNF474-LOC100505841, FOXF2-FOXQ1, VTA1-GPR126, SH3PXD2A, HTRA1-ARMS2, COL4A2) were found to be associated in the multi-trait analysis with cerebral white matter hyperintensities (n=42 310). Two of the identified loci contain genes (COL4A2 and HTRA1) that are involved in monogenic lacunar stroke. The TWAS identified associations between the expression of six genes (SCL25A44, ULK4, CARF, FAM117B, ICA1L, NBEAL1) and lacunar stroke. Pathway analyses implicated disruption of the extracellular matrix, phosphatidylinositol 5 phosphate binding, and roundabout binding (false discovery rate <0·05). Mendelian randomisation analyses identified positive associations of elevated blood pressure, history of smoking, and type 2 diabetes with lacunar stroke. INTERPRETATION: Lacunar stroke has a substantial heritable component, with 12 loci now identified that could represent future treatment targets. These loci provide insights into lacunar stroke pathogenesis, highlighting disruption of the vascular extracellular matrix (COL4A2, LOX, SH3PXD2A, GPR126, HTRA1), pericyte differentiation (FOXF2, GPR126), TGF-β signalling (HTRA1), and myelination (ULK4, GPR126) in disease risk. FUNDING: British Heart Foundation

<原著>脳血管障害による片麻痺患者の身体イメージ理解の試み

片麻痺患者の身体イメージを理解することを目的に, 片麻痺患者29名にSD法による身体イメージの測定を行った。方法は, 川原ら(1991)が身体イメージの因子として抽出した5因子, 1.評価性, 2.活動性・俊敏性, 3.活動秩序感, 4.力量, 5.情動的感情的の中から片麻痺の表現に適すると思われた形容詞対の中から25項目選択した。測定は上肢と下肢にそれぞれ7段階の評価尺度を用いた。さらに, 身体のイメージを12色の色鉛筆で表現してもらった。結果は, 平均で見ると上肢を下肢よりもマイナスのイメージでとらえる傾向がみられた。また, 重い-軽いというような力量性を表す形容詞対でイメージが反映されやすいことが分かった。身体の色のイメージは上肢下肢とも赤系, 青系, 黒をイメージする者が多かった。下肢の機能と比較し上肢の機能は複雑であることがイメージの違いになった可能性が示唆された。The purpose of this study was to understand hemiplegia patient's body image by the SD method (semantic differential method). We selected the adjective pair thought suitable for the expression of the hemiplegia patient by 25 items from among five factors which Kawahara (1991) had extracted as a factor of the body image. The measurement used the evaluation standard of seven steps for the arm and lower limbs respectively. In addition, the image of the body was had to be expressed with 12 color colored pencil. When the result was seen on the average, the tendency where the arm was caught from lower limbs in the image of the minus was seen. Moreover, it has been understood that the image is reflected easily by the adjective pair for potency factor such as heavylight. As for the image of the color of the body, there were many persons who imaged the arm lower limbs, the red system, the blue system, and the black. As for the function of the leg, the possibility that the complexity becomes different of the image was suggested compared with the function of lower limbs.国立情報学研究所で電子