Correlation between Subjective Nasal Patency and Intranasal Airflow Distribution

Objectives (1) Analyze the relationship between intranasal airflow distribution and subjective nasal patency in healthy and nasal airway obstruction (NAO) cohorts using computational fluid dynamics (CFD). (2) Determine whether intranasal airflow distribution is an important objective measure of airflow sensation that should be considered in future NAO virtual surgery planning. Study Design Cross-sectional. Setting Academic tertiary medical center and academic dental clinic. Subjects and Methods Three-dimensional models of nasal anatomy were created based on computed tomography scans of 15 patients with NAO and 15 healthy subjects and used to run CFD simulations of nasal airflow and mucosal cooling. Subjective nasal patency was quantified with a visual analog scale (VAS) and the Nasal Obstruction Symptom Evaluation (NOSE). Regional distribution of nasal airflow (inferior, middle, and superior) was quantified in coronal cross sections in the narrowest nasal cavity. The Pearson correlation coefficient was used to quantify the correlation between subjective scores and regional airflows. Results Healthy subjects had significantly higher middle airflow than patients with NAO. Subjective nasal patency had no correlation with inferior and superior airflows but a high correlation with middle airflow (|r| = 0.64 and |r| = 0.76 for VAS and NOSE, respectively). Anterior septal deviations tended to shift airflow inferiorly, reducing middle airflow and reducing mucosal cooling in some patients with NAO. Conclusion Reduced middle airflow correlates with the sensation of nasal obstruction, possibly due to a reduction in mucosal cooling in this region. Further research is needed to elucidate the role of intranasal airflow distribution in the sensation of nasal airflow

Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase

Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia. We monitored the effect of airflow on electro-olfactogram (EOG) responses and found that the MOE of mice can sense mechanical forces generated by airflow. The airflow-sensitive EOG response in the MOE was attenuated when cAMP was increased by odorants or by forskolin suggesting a common mechanism for airflow and odorant detection. In addition, the sensitivity to airflow was significantly impaired in the MOE from AC3−/− mice. We conclude that AC3 in the MOE is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing

Airflow distortion at instrument sites on the RRS James Clark Ross during the WAGES project

Wind speed measurements obtained from anemometers mounted on ships are prone to systematic errors caused by the distortion of the airflow around the ship's hull and superstructure. This report describes the results of simulations of the airflow around the RRS James Clark Ross made using the computational fluid dynamics (CFD) software VECTIS. The airflow distortion at anemometer sites used during the WAGES project has been quantified at a wind speed of 10 m/s for relative wind directions of 0 (bow-on), 10, 20, 30, 50, 70, 90 and 110 degrees off the bow. The anemometers used in this study were located in the bows of the ship. Temperature sensors were located on the port side of the monkey island. For bow-on flows the anemometers in the bows of the ship experienced relatively small flow distortion. At these sites the flow was decelerated by about 1% of the free stream wind speed. Over the full range of relative wind directions the flow to the R3 sonic is generally accelerated with the largest wind speed biases at flows directly over the beam. The vertical displacement of the airflow increases from around 1 to 2 m for flows directly over the bow, to around 5m for flows over the ships beam as the blockage of the airflow by the ship becomes greater.The airflow distortion at the temperature sensor locations above the monkey island was typically greater than the well-exposed foremast locations. These locations experienced wind speed biases from 6% increase for an airflow directly over the bow, to large decelerations of 55 % when the instruments were in the large recirculation region for flows directly over the starboard side

A comparison of different ventilation strategies for dwellings in terms of airflow rates and airflow paths

The context of ventilation in Belgian dwellings has changed since the publication of the Belgian standard NBN D 50-001:1991. Due to the higher energy performance of these dwellings, ventilation plays nowadays a more essential role in maintaining a good indoor air quality. Therefore, new rules for improved ventilation strategies are needed to accomplish high energy-efficient ventilation while providing a good indoor air quality. A first step is to compare different ventilation strategies, including strategies that don’t comply with the current standard, in terms of airflow rates and airflow paths. This comparison also includes the influence of demand controlled ventilation. This paper covers a simulation study using multi-zone airflow and contaminant transport calculation software (CONTAM) which compares the performances of the different ventilation strategies in terms of indoor air quality and average airflow rates. The evaluation of the indoor air quality is based on the exposure of the occupants to CO2 and VOC and on the relative humidity in the rooms. The different ventilation strategies can achieve a comparable indoor air quality, including the strategies not conform to the Belgian standard. However, some strategies require up to twice the airflow rate than others

Experimental and CFD airflow studies of a cleanroom with special respect to air supply inlets

Investigations were carried out into the airflow in a non-unidirectional airflow cleanroom and its affect on the local airborne particle cleanliness The main influence was the method of air supply A supply inlet with no diffuser gave a pronounced downward jet flow and low levels of contamination below it, but poorer than average conditions in much of the rest of the room A 4-way diffuser gave much better air mixing and a more even airborne particle concentration throughout the cleanroom Other variables such as air inlet supply velocity, temperature difference between air supply and the room, and the release position of contamination also influenced the local airborne cleanliness A CFD analysis of airflow fields in a cleanroom was compared with measured values It was considered that a turbulent intensity of 6%, and a hydraulic diameter based on the actual size of the air inlet, should be used for the inlet boundary conditions and, when combined with a k-epsilon standard turbulence model, a reasonable prediction of the airflow and airborne particle concentration was obtained

Airflow in stop-vowel sequences of German

This study reports on the results of an airflow experiment that measured the duration of airflow and the amount of air from release of a stop to the beginning of a following vowel in stop vowel-sequences of German

Distributed educated throat stability bypass to increase the stable airflow range of a Mach 2.5 inlet with 60-percent internal contraction

The results of an experimental investigation to increase the stable airflow operating range of a supersonic mixed-compression inlet are presented. A distributed educated throat stability-bypass entrance configuration was tested. In terms of diffuser-exit corrected airflow, a large inlet stable airflow range of about 16.1 percent was obtained if a constant pressure was maintained in the bypass plenum. Limited unstart angle of attack data are presented

Compression Pylon

A compression pylon for an aircraft with a wing-mounted engine, that does not cause supersonic airflow to occur within the fuselage-wing-pylon-nacelle channel is presented. The chord length of the pylon is greater than the local chord length of the wing to which it is attached. The maximum thickness of the pylon occurs at a point corresponding to the local trailing edge of the wing. As a result, the airflow through the channel never reaches supersonic velocities

Distributed porous throat stability bypass to increase the stable airflow range of a Mach 2.5 inlet with 60 percent internal contraction

The results of an experimental investigation to increase the stable airflow operating range of a supersonic, mixed-compression inlet with 60-percent internal contraction are presented. Various distributed-porous, throat stability-bypass entrance configurations were tested. In terms of diffuser-exit corrected airflow, a large inlet stable airflow range of about 25 percent was obtained with the optimum configuration if a constant pressure was maintained in the by-pass plenum. The location of the centerbody bleed region had a decided effect on the overall inlet performance. Limited unstart angle-of-attack data are presented

Numerical simulation of convective airflow in an empty room

Numerical simulation of airflow inside an empty room has been carried out for a forced convection, a natural convection and a mixed convection respectively, by using a computational fluid dynamics approach of solving the Reynolds-averaged Navier-Stokes fluid equations. Two-dimensional model was studied at first; focusing on the grid refinement, the mesh topology effect, and turbulence model influences. It was found that structured mesh results are in better agreement with available experimental measurements for all three scenarios. Further study using a three-dimensional model has shown very good agreements with test data at measuring points. Furthermore, present studies have revealed low-frequency flow unsteadiness by monitoring the time history of flow variables at measuring positions. This phenomenon has not yet reported and discussed in previous studies