Research options for controlling Zoonotic disease in India, 2010-2015

BACKGROUND: Zoonotic infections pose a significant public health challenge for low- and middle-income countries and have traditionally been a neglected area of research. The Roadmap to Combat Zoonoses in India (RCZI) initiative conducted an exercise to systematically identify and prioritize research options needed to control zoonoses in India. METHODS AND FINDINGS: Priority setting methods developed by the Child Health and Nutrition Research Initiative were adapted for the diversity of sectors, disciplines, diseases and populations relevant for zoonoses in India. A multidisciplinary group of experts identified priority zoonotic diseases and knowledge gaps and proposed research options to address key knowledge gaps within the next five years. Each option was scored using predefined criteria by another group of experts. The scores were weighted using relative ranks among the criteria based upon the feedback of a larger reference group. We categorized each research option by type of research, disease targeted, factorials, and level of collaboration required. We analysed the research options by tabulating them along these categories. Seventeen experts generated four universal research themes and 103 specific research options, the majority of which required a high to medium level of collaboration across sectors. Research options designated as pertaining to 'social, political and economic' factorials predominated and scored higher than options focussing on ecological, genetic and biological, or environmental factors. Research options related to 'health policy and systems' scored highest while those related to 'research for development of new interventions' scored the lowest. CONCLUSIONS: We methodically identified research themes and specific research options incorporating perspectives of a diverse group of stakeholders. These outputs reflect the diverse nature of challenges posed by zoonoses and should be acceptable across diseases, disciplines, and sectors. The identified research options capture the need for 'actionable research' for advancing the prevention and control of zoonoses in India

Exploring local knowledge and perceptions on zoonoses among pastoralists in northern and eastern Tanzania

Background: Zoonoses account for the most commonly reported emerging and re-emerging infectious diseases in Sub-Saharan Africa. However, there is limited knowledge on how pastoral communities perceive zoonoses in relation to their livelihoods, culture and their wider ecology. This study was carried out to explore local knowledge and perceptions on zoonoses among pastoralists in Tanzania. Methodology and principal findings: This study involved pastoralists in Ngorongoro district in northern Tanzania and Kibaha and Bagamoyo districts in eastern Tanzania. Qualitative methods of focus group discussions, participatory epidemiology and interviews were used. A total of 223 people were involved in the study. Among the pastoralists, there was no specific term in their local language that describes zoonosis. Pastoralists from northern Tanzania possessed a higher understanding on the existence of a number of zoonoses than their eastern districts' counterparts. Understanding of zoonoses could be categorized into two broad groups: a local syndromic framework, whereby specific symptoms of a particular illness in humans concurred with symptoms in animals, and the biomedical framework, where a case definition is supported by diagnostic tests. Some pastoralists understand the possibility of some infections that could cross over to humans from animals but harm from these are generally tolerated and are not considered as threats. A number of social and cultural practices aimed at maintaining specific cultural functions including social cohesion and rites of passage involve animal products, which present zoonotic risk. Conclusions: These findings show how zoonoses are locally understood, and how epidemiology and biomedicine are shaping pastoralists perceptions to zoonoses. Evidence is needed to understand better the true burden and impact of zoonoses in these communities. More studies are needed that seek to clarify the common understanding of zoonoses that could be used to guide effective and locally relevant interventions. Such studies should consider in their approaches the pastoralists' wider social, cultural and economic set up

Invisible and ignored: lifting the lid on the problems of endemic zoonosez

No abstract available

Zoonosis emergence linked to agricultural intensification and environmental change

A systematic review was conducted by a multidisciplinary team to analyze qualitatively best available scientific evidence on the effect of agricultural intensification and environmental changes on the risk of zoonoses for which there are epidemiological interactions between wildlife and livestock. The study found several examples in which agricultural intensification and/or environmental change were associated with an increased risk of zoonotic disease emergence, driven by the impact of an expanding human population and changing human behavior on the environment. We conclude that the rate of future zoonotic disease emergence or reemergence will be closely linked to the evolution of the agriculture–environment nexus. However, available research inadequately addresses the complexity and interrelatedness of environmental, biological, economic, and social dimensions of zoonotic pathogen emergence, which significantly limits our ability to predict, prevent, and respond to zoonotic disease emergence

Adjustment and Completion of BASNEF Model to Provide a New Model for Educating Large Populations in Relation to Cutaneous Leishmaniasis

Background: Educational models that have been created for educating small populations do not have enough efficacy for educating large populations, so based on this premise and also high prevalence of Cutaneous Leishmaniasis (CL) in the Islamic Republic of Iran and lack of efficient methods for CL control, this study was designed and done with the aim of applying BASNEF model to provide a new model for educating large populations in relation to Cutaneous Leishmaniasis. Methods: In a quasi-experimental study, 60 Volunteer Health Workers (VHWS) and 120 households that were resident in endemic areas of CL in Yazd were selected through census and multi-stage sampling method, respectively. Then, educational intervention was designed and implemented on the basis of BASNEF model. After educating VHWS based on BASNEF model, they were asked to educate households on the basis of BASNEF model. Before and after 3 months of VHWS training activities, data were collected in intervention and control groups via valid and reliable questionnaires and were analyzed with the SPSS software. Results: The mean score of knowledge, attitude, behavioral intention, enabling factors, behaviors and influence of subjective norms after educational intervention in households in experimental were significantly increased (P<0.05) while the changes in control group were not significant. Conclusions: This educational program led to empowering of VHWS and a change in their educational behavior which in turn led to preventive measures in households under study region. It can be concluded that the new educational model presented in this research, formed based on the BASNEF model, is able to educate a large population. Keywords: BASNEF Model, Volunteer Health Workers, Health Education, Cutaneous Leishmaniasi

Prediction and prevention of the next pandemic zoonosis.

Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes. Despite their substantial effects on global public health and growing understanding of the process by which they emerge, no pandemic has been predicted before infecting human beings. We review what is known about the pathogens that emerge, the hosts that they originate in, and the factors that drive their emergence. We discuss challenges to their control and new efforts to predict pandemics, target surveillance to the most crucial interfaces, and identify prevention strategies. New mathematical modelling, diagnostic, communications, and informatics technologies can identify and report hitherto unknown microbes in other species, and thus new risk assessment approaches are needed to identify microbes most likely to cause human disease. We lay out a series of research and surveillance opportunities and goals that could help to overcome these challenges and move the global pandemic strategy from response to pre-emption

Methods for prioritization: Toward quantitative approach to prioritize zoonoses in South East Asia

Resources for research, surveillance, control and others public health activities are limited and it is difficult to compare the importance of diseases, which vary in terms of occurrence, impacts, etc. So, in this context of scarce resources and multiple competing priorities, it is necessary to allocate rationally human and financial resources on relevant health priorities. Prioritization is an objective tool to make the best use of limited human and financial resources for funders of research and for organizations in charge of diseases' surveillance and implementation of disease control. In order to develop an efficient method for prioritization of zoonotic diseases in South East Asia, we performed a literature review on the different methods already developed to rank diseases. Several priority setting procedures have been used and described by various organizations (national, regional or international) and technical institutions with different models and goals. Mainly, qualitative and semi-quantitative approaches are used, in which experts are asked to score some criteria against which diseases are prioritized. Few initiatives for quantitative models have been undergone yet, mainly in the field of the food-borne diseases. Whatever the approach used to perform the prioritization exercise, some limitations to the current developed models arise from the analysis of scientific articles and organization reports. Following the identification of weak points in the methods already applied, we discuss about the potential means that can be used to improve current models or to develop innovative tools for prioritization of zoonoses in the specific context of South East Asia. (Résumé d'auteur

Zoonotic diseases: sharing insights from interdisciplinary research

Researchers and others involved with the Zoonoses and Emerging Livestock Systems (ZELS) initiative gathered in Tanzania earlier this year to discuss progress with projects being carried out as part of the five- year programme. Mary Ryan and Sarah Cleaveland report