Adult Pure Yolk Sac Tumor of The Testis.

Adult pure yolk sac tumor (YST) is extremely rare. In childhood pure yolk sac tumors are most frequently seen, whereas component of mixed germ cell testicular tumors observed in adults. They have different biological behavior than the childhood tumors. We herein report a case of adult pure yolk sac tumor of left testis in 40 years old man. Until now limited number of the cases has been reported in the literature

Yolk sac tumor in children and the resulting biopsychosocial and spiritual aspects

Yolk sac tumor is a rare germ cell tumor in children, accounting for only about 3.5% of pediatric cancers. However, the yolk sac tumor is a malignant tumor that requires chemotherapy, but the side effects of chemotherapy can have an impact on the biopsychosocial and spiritual aspects of the child. This case report presents the negative impacts on the biopsychosocial and spiritual aspects of a child diagnosed with a yolk sac tumor. 11-year-old girl experienced symptoms of an enlarged abdomen, feeling bloated, pain, and frequent urination. The pathological examination revealed a yolk sac tumor, and the examination of ascites showed malignant cells. The patient was diagnosed with a yolk sac tumor, Stage 1C3, and was to undergo chemotherapy. She scored 15, indicating that the patient experienced anxiety due to the yolk sac tumor diagnosis and was anxious about the side effects of chemotherapy. Examination of the biological, psychological, social, and spiritual aspects in pediatric patients with a yolk sac tumor can assist in addressing the adverse effects of the diagnosis and the anxiety about chemotherapy in a more comprehensive manner

Mediastinal yolk sac tumor infiltrating the heart

Background: As a rare tumor, yolk sac tumor is a type of neoplasm that appears like the yolk sac, extraembryonic mesenchyme, and allantois. The mediastinum is the second most frequent area after the gonadal area. Case report: We present an extremely rare case of 15 years old boy with mediastinal yolk sac tumor. The boy came with the chief complaint of swelling of the neck and face. Computed tomography scan of the chest revealed bulky mass with a cystic component that infiltrated the heart. The diagnosis of mediastinal yolk sac tumor was made after core needle biopsy. Histopathologic analysis revealed tumor mass with solid and microcystic structure and pleomorphic nucleus within the tumor cells. Laboratory finding showed elevated serum alpha-fetoprotein level reaching more than 8000 ng/ml. Echocardiography revealed a mass in the right atrium. The patient condition was rapidly deteriorated due to his vena cava superior syndrome. Unfortunately, the patient died two days after diagnosis and we did not have the chance to do the therapy. Conclusion: Mediastinal yolk sac tumor is a rare malignancy that requires comprehensive management. The diagnosis should be made based on histopathological findings with the addition of thoracic computer tomography scan to assess the degree of infiltration to surrounding organ. A life-threatening condition such as vena cava superior syndrome should be assessed promptly to allow for immediate treatment

Gastric Yolk Sac Tumor: A Case Report and Review of the Literature

Gastric yolk sac tumors are extremely rare and their prognosis is poor; most patients have widespread metastases at the time of diagnosis. The treatment of gastric yolk sac tumors consists of aggressive chemotherapy combined with radiotherapy and surgery. Here, we first report a case of gastric yolk sac tumor presenting as an early gastric cancer that was cured after a gastrectomy with lymphadenectomy

TESTICULAR YOLK SAC TUMOR IN AN ONE- YEAR AND SEVENT- MONTHS OLD

Background: Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. He most common testicular tumor in young children under the age of 3 is yolk sac tumor, and it is also known as infantile embryonal carcinoma. Case Presentation: We present the clinical future YST in an one- year and sevent-months old. In this report, we described testicular of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment. It has been suggested that alpha-fetoprotein (AFP) can be applied as a feasible tumor marker because its level was elevated in 90% of YST. The treatment generally involves debulking surgery of tumors followed by systemic chemotherapy. Conclusion: Our case report has a good prognosis because good responds with chemotherapy. Although YST is rare in children, pediatric physicians should be aware of this and prompt treatment should be addressed.Keywords: yolk sac tumor, chemotherapy, pediatri

Intracranial yolk sac tumor in an adult patient: MRI, diffusion-weighted imaging and 1H MR spectroscopy features

Introduction. Yolk sac tumors represent only 5%-7% of intracranial germ cell tumors, which comprise about 1% of all primary brain tumors in adults. Literature data about nonspecific imaging characteristics of these tumors are scant. We presented magnetic resonance imaging findings with diffusion-weighted imaging and proton magnetic resonance spectroscopy of this rare type of tumor in an adult patient. Case report. A 55-year-old man with progressive left side weakness, headache, dizziness and ataxia, underwent preoperative magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy. After surgical resection and histological analysis, the final diagnosis of yolk sac tumor was established. Retrospective imaging analysis were performed in order to determine imaging and biochemical parameters that could be useful in the diagnostic evaluation of this tumor type. Conclusion. Though the imaging features of yolk sac tumor are not specific, morphoanatomical and metabolic imaging could offer the information that provides new insights into this tumor that may facilitate further therapeutic decision process and potentially provides better information regarding the disease prognosis

Online) An Open Access

ABSTRACT Yolk sac tumor with pregnancy is a rare neoplasm. There is a therapeutic dilemma for the treatment of pregnant patient with yolk sac tumor requiring chemotherapy. Our case was a pregnant woman with 24 weeks gestation with yolk sac tumor, removed by laparotomy. Chemotherapy was delayed till after delivery. Both mother and child are well 20 weeks after last dose of chemotherapy

Rare incidence of yolk sac tumor in pregnancy posing management challenge: a case report

Yolk sac tumor of the ovary, although rare but highly malignant, when diagnosed in a pregnant woman is difficult to manage because of risks involved to the fetus but with the advent of surgery and chemotherapy prognosis has greatly improved.A G3P2L2, 35 years old, woman got admitted at 8 months amenorrhea with absent fetal movements since two days with labor pains. She carried an ultrasound report, done at a private clinic which showed intrauterine death of fetus along with a pelvic tumor. Her CT done at our hospital confirmed a pelvic tumor mass posterior to the uterus and in close proximity with the rectum. A laparotomy was planned for her as the pelvic mass was preventing the descent of fetal head thus hindering vaginal delivery. Biopsy from the tumor mass revealed yolk sac tumor of the ovary. Her general condition was poor with low Hb levels and deranged LFT and KFT and was shifted to ICU for intensive care but she could not survive despite the best efforts.Early diagnosis of ovarian yolk sac tumor in pregnancy leads to timely intervention in the forms of surgery and chemotherapy which greatly improves the survival rates

Yolk Sac Tumor (Endodermal Sinus Tumor) with Component of Mature Cystic Teratoma at Sacrococcygeal Region in Children less than Two Years - A Case Series

Sacrococcygeal germ cell tumors in neonates and infants are always primary. About 75-95% of the cases occur in females. Chromosomal analysis of these extragonadal teratomas suggest that they arise from postmitotic/ premitotic cells. The majority of sacrococcygeal tumors are benign, teratomas. These benign teratomas have potential for malignant transformation. The most common malignancy which can occur is yolk sac tumor (YST) also known as endodermal sinus tumor (EST). Malignant germ cell tumors account for 3% of childhood neoplasms and extragonadal germ cell tumor constitutes 1–5% of all germ cell tumors which are highly aggressive. Presented here are three cases of yolk sac tumor arising in a sacrococcygeal mature cystic teratoma in less than 2 years of age

Yolk Sac TumorMasquerading AsPericarditis: A Case Report

Introduction:Yolk sac tumor is a rare form of a germ cell tumor (GCT).This case report describes an unusual presentation of a yolk sac tumor with pericarditis, pericardial effusionand bilateral microlithiasis (MT) in a young Vietnamese male with extragonadal GCT in the anterior mediastinum. Presentation of Case:A 23-year-old Vietnamese male with one-pack year smoking history, but no other significant past medical history presented with nonproductive cough and pleuritic chest pain for 2 weeks. Chest pain was described as sharp and localized to the right-side of his substernal area. B-symptoms were present for 1 month and included: weight loss of 10lbs, night sweats and fever.Physical exam showeddiminished breath sounds on the right side of the chest w/o accessory muscle use. CT of the chest revealed a large 14 cm round mass in the right middle lobe with possible extension to the mediastinum, moderate right pleural effusion and pericardial effusion.EKG showed a pattern consistent with pericarditis. Biopsy of the mediastinal mass was consistent with yolk sac tumor. LDH was 543, AFP 7200, and β-HCG2.Testicular ultrasound did not find any testicular masses, but there was bilateral testicular microlithiasis. The patient was started on BEP (Bleomycin + Etoposide + Cisplatin) chemotherapy with subsequent thoracotomy and mass resection.Conclusion:Younger patients presenting with pleural effusions and pericarditis need a detailed history and physical examination in order to diagnosea yolk sac tumor