Human-machine Interactive Tissue Prototype Learning for Label-efficient Histopathology Image Segmentation

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining pixel-level labels for supervised learning in clinical practice is often infeasible. Alternatively, weakly-supervised segmentation methods have been explored with less laborious image-level labels, but their performance is unsatisfactory due to the lack of dense supervision. Inspired by the recent success of self-supervised learning methods, we present a label-efficient tissue prototype dictionary building pipeline and propose to use the obtained prototypes to guide histopathology image segmentation. Particularly, taking advantage of self-supervised contrastive learning, an encoder is trained to project the unlabeled histopathology image patches into a discriminative embedding space where these patches are clustered to identify the tissue prototypes by efficient pathologists' visual examination. Then, the encoder is used to map the images into the embedding space and generate pixel-level pseudo tissue masks by querying the tissue prototype dictionary. Finally, the pseudo masks are used to train a segmentation network with dense supervision for better performance. Experiments on two public datasets demonstrate that our human-machine interactive tissue prototype learning method can achieve comparable segmentation performance as the fully-supervised baselines with less annotation burden and outperform other weakly-supervised methods. Codes will be available upon publication.Comment: IPMI2023 camera read

Weakly Supervised Cross-Lingual Named Entity Recognition via Effective Annotation and Representation Projection

The state-of-the-art named entity recognition (NER) systems are supervised machine learning models that require large amounts of manually annotated data to achieve high accuracy. However, annotating NER data by human is expensive and time-consuming, and can be quite difficult for a new language. In this paper, we present two weakly supervised approaches for cross-lingual NER with no human annotation in a target language. The first approach is to create automatically labeled NER data for a target language via annotation projection on comparable corpora, where we develop a heuristic scheme that effectively selects good-quality projection-labeled data from noisy data. The second approach is to project distributed representations of words (word embeddings) from a target language to a source language, so that the source-language NER system can be applied to the target language without re-training. We also design two co-decoding schemes that effectively combine the outputs of the two projection-based approaches. We evaluate the performance of the proposed approaches on both in-house and open NER data for several target languages. The results show that the combined systems outperform three other weakly supervised approaches on the CoNLL data.Comment: 11 pages, The 55th Annual Meeting of the Association for Computational Linguistics (ACL), 201

Backtracking Spatial Pyramid Pooling (SPP)-based Image Classifier for Weakly Supervised Top-down Salient Object Detection

Top-down saliency models produce a probability map that peaks at target locations specified by a task/goal such as object detection. They are usually trained in a fully supervised setting involving pixel-level annotations of objects. We propose a weakly supervised top-down saliency framework using only binary labels that indicate the presence/absence of an object in an image. First, the probabilistic contribution of each image region to the confidence of a CNN-based image classifier is computed through a backtracking strategy to produce top-down saliency. From a set of saliency maps of an image produced by fast bottom-up saliency approaches, we select the best saliency map suitable for the top-down task. The selected bottom-up saliency map is combined with the top-down saliency map. Features having high combined saliency are used to train a linear SVM classifier to estimate feature saliency. This is integrated with combined saliency and further refined through a multi-scale superpixel-averaging of saliency map. We evaluate the performance of the proposed weakly supervised topdown saliency and achieve comparable performance with fully supervised approaches. Experiments are carried out on seven challenging datasets and quantitative results are compared with 40 closely related approaches across 4 different applications.Comment: 14 pages, 7 figure