Character-Word LSTM Language Models

We present a Character-Word Long Short-Term Memory Language Model which both reduces the perplexity with respect to a baseline word-level language model and reduces the number of parameters of the model. Character information can reveal structural (dis)similarities between words and can even be used when a word is out-of-vocabulary, thus improving the modeling of infrequent and unknown words. By concatenating word and character embeddings, we achieve up to 2.77% relative improvement on English compared to a baseline model with a similar amount of parameters and 4.57% on Dutch. Moreover, we also outperform baseline word-level models with a larger number of parameters

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis

Wnt signaling plays a major role in bone homeostasis and mechanotransduction, but its role and regulatory mechanism in osteoclast development are not fully understood. Through genome-wide in silico analysis, we examined Wnt3a-driven regulation of osteoclast development. Mouse bone marrow-derived cells were incubated with RANKL in the presence and absence of Wnt3a. Using microarray mRNA expression data, we conducted principal component analysis and predicted transcription factor binding sites (TFBSs) that were potentially involved in the responses to RANKL and Wnt3a. The principal component analysis predicted potential Wnt3a responsive regulators that would reverse osteoclast development, and a TFBS prediction algorithm indicated that the AP1 binding site would be linked to Wnt3a-driven suppression. Since c-Fos was upregulated by RANKL and downregulated by Wnt3a in a dose-dependent manner, we examined its role using RNA interference. The partial silencing of c-Fos suppressed RANKL-driven osteoclastogenesis by downregulating NFATc1, a master transcription factor of osteoclast development. Although the involvement of c-Myc was predicted and partially silencing c-Myc slightly reduced the level of TRAP, c-Myc silencing did not alter the expression of NFATc1. Collectively, the presented systems-biology approach demonstrates that Wnt3a attenuates RANKL-driven osteoclastogenesis by blocking c-Fos expression and suggests that mechanotransduction of bone alters the development of not only osteoblasts but also osteoclasts through Wnt signaling

Inelastic scattering of electrons by metastable hydrogen atoms in a laser field

The inelastic scattering of fast electrons by metastable hydrogen atoms in the presence of a linearly polarized laser field is theoretically studied in the domain of moderate field intensities. The interaction of the hydrogen atom with the laser field is described by first-order time-dependent perturbation theory, while the projectile electrons interacting with the laser field are described by the Gordon-Volkov wave functions. An analytic expression is obtained for the differential scattering cross section in the first-order Born approximation for laser-assisted inelastic e-H(2s) scattering for the 2s-nl excitation. Detailed analytical and numerical results are presented for inelastic scattering accompanied by one-photon absorption, and the angular dependence and resonance structure of the differential cross sections is discussed for the 2s -4l excitation of metastable hydrogen

Group disagreement: a belief aggregation perspective

The debate on the epistemology of disagreement has so far focused almost exclusively on cases of disagreement between individual persons. Yet, many social epistemologists agree that at least certain kinds of groups are equally capable of having beliefs that are open to epistemic evaluation. If so, we should expect a comprehensive epistemology of disagreement to accommodate cases of disagreement between group agents, such as juries, governments, companies, and the like. However, this raises a number of fundamental questions concerning what it means for groups to be epistemic peers and to disagree with each other. In this paper, we explore what group peer disagreement amounts to given that we think of group belief in terms of List and Pettit’s ‘belief aggregation model’. We then discuss how the so-called ‘equal weight view’ of peer disagreement is best accommodated within this framework. The account that seems most promising to us says, roughly, that the parties to a group peer disagreement should adopt the belief that results from applying the most suitable belief aggregation function for the combined group on all members of the combined group. To motivate this view, we test it against various intuitive cases, derive some of its notable implications, and discuss how it relates to the equal weight view of individual peer disagreement

On preparation of the W-states from atomic ensembles

A scheme, where three atomic ensembles can be prepared in the states of the W-class via Raman type interaction of strong classical field and a projection measurement involved three single-photon detectors and two beamsplitters, are considered. The obtained atomic entanglement consists of the Dicke or W-states of each of the ensembles.Comment: 4 pages, 1 figure, minor correction