Whole brain functional connectivity using phase locking measures of resting state magnetoencephalography

The analysis of spontaneous functional connectivity (sFC) reveals the statistical connections between regions of the brain consistent with underlying functional communication networks within the brain. In this work, we describe the implementation of a complete all-to-all network analysis of resting state neuronal activity from magnetoencephalography (MEG). Using graph theory to define networks at the dipole level, we established functionally defined regions by k-means clustering cortical surface locations using Eigenvector centrality (EVC) scores from the all-to-all adjacency model. Permutation testing was used to estimate regions with statistically significant connections compared to empty room data, which adjusts for spatial dependencies introduced by the MEG inverse problem. In order to test this model, we performed a series of numerical simulations investigating the effects of the MEG reconstruction on connectivity estimates. We subsequently applied the approach to subject data to investigate the effectiveness of our method in obtaining whole brain networks. Our findings indicated that our model provides statistically robust estimates of functional region networks. Application of our phase locking network methodology to real data produced networks with similar connectivity to previously published findings, specifically, we found connections between contralateral areas of the arcuate fasciculus that have been previously investigated. The use of data-driven methods for neuroscientific investigations provides a new tool for researchers in identifying and characterizing whole brain functional connectivity networks. © 2014 Schmidt, Ghuman and Huppert

GKP Signal Processing Using Deep CNN and SVM for Tongue-Machine Interface

The tongue is one of the few organs with high mobility in the case of severe spinal cord injuries. However, most tongue-machine interfaces (TMIs) require the patient to wear obtrusive and unhygienic devices in and around the mouth. This paper aims to develop a TMI based on the glossokinetic potentials (GKPs), i.e. the electrical signals generated by the tongue when it touches the buccal walls. Ten patients were recruited for this research. The GKP patterns were classified by convolutional neural network (CNN) and support vector machine (SVM). It was observed that the CNN outperformed the SVM in individual and average scores for both raw and preprocessed datasets, reaching an accuracy of 97 similar to 99%. The CNN-based GKP processing method makes it easy to build a natural, appealing and robust TMI for the paralyzed. Being the first attempt to process GKPs with the CNN, our research offers an alternative to the traditional brain-computer interfaces (BCIs), which suffers from the instability and low signal-to-noise ratio (SNR) of electroencephalography (EEG)

Changes in the EEG Spectrum of a Child with Severe Disabilities in Response to Power Mobility Training

Literature suggests that self-generated locomotion in infancy and early childhood enhances the development of various cognitive processes such as spatial awareness, social interaction, language development and differential attentiveness. Thus, having access to a power mobility device may play a crucial role for the overall development, mental health, and quality of life of children with multiple, severe disabilities who have limited motor control. This study investigates the feasibility of using electroencephalography (EEG) as an objective measure to detect changes in brain activity in a child due to power mobility training. EEG data was collected with a modified wireless neuroheadset using a single-subject A-B-A-B design consisting of two baseline phases (A) and two intervention phases (B). One trial consisted of three different activities during baseline phase; resting condition at the beginning (Resting 1) and at the end (Resting 2) of the trial, interaction with adults, and passive mobility. The intervention phase included a forth activity, the use of power mobility, while power mobility training was performed on another day within the same week of data collection. The EEG spectrum between 2.0 and 12.0 Hz was analyzed for Resting 1 and Resting 2 condition in each phase. We found significant increase of theta power and decrease in alpha power during all three phases following the first baseline. In respect of previous findings, these observations may be related to an increase in alertness and/or anticipation. Analysis of the percentage change from Resting 1 to Resting 2 condition revealed decrease in theta and increasing alpha power during the first intervention phase, which could be associated with increasing cognitive capacity immediately after the use of power mobility. Overall, no significant difference between baseline phase and intervention phase was observed. Thus, whether the observed changes may have been influenced or enhanced by power mobility training remains unclear and warrants further investigation

Signal Processing and Machine Learning Techniques Towards Various Real-World Applications

abstract: Machine learning (ML) has played an important role in several modern technological innovations and has become an important tool for researchers in various fields of interest. Besides engineering, ML techniques have started to spread across various departments of study, like health-care, medicine, diagnostics, social science, finance, economics etc. These techniques require data to train the algorithms and model a complex system and make predictions based on that model. Due to development of sophisticated sensors it has become easier to collect large volumes of data which is used to make necessary hypotheses using ML. The promising results obtained using ML have opened up new opportunities of research across various departments and this dissertation is a manifestation of it. Here, some unique studies have been presented, from which valuable inference have been drawn for a real-world complex system. Each study has its own unique sets of motivation and relevance to the real world. An ensemble of signal processing (SP) and ML techniques have been explored in each study. This dissertation provides the detailed systematic approach and discusses the results achieved in each study. Valuable inferences drawn from each study play a vital role in areas of science and technology, and it is worth further investigation. This dissertation also provides a set of useful SP and ML tools for researchers in various fields of interest.Dissertation/ThesisDoctoral Dissertation Electrical Engineering 201

Spectrum sensing for cognitive radio and radar systems

The use of the radio frequency spectrum is increasing at a rapid rate. Reliable and efficient operation in a crowded radio spectrum requires innovative solutions and techniques. Future wireless communication and radar systems should be aware of their surrounding radio environment in order to have the ability to adapt their operation to the effective situation. Spectrum sensing techniques such as detection, waveform recognition, and specific emitter identification are key sources of information for characterizing the surrounding radio environment and extracting valuable information, and consequently adjusting transceiver parameters for facilitating flexible, efficient, and reliable operation. In this thesis, spectrum sensing algorithms for cognitive radios and radar intercept receivers are proposed. Single-user and collaborative cyclostationarity-based detection algorithms are proposed: Multicycle detectors and robust nonparametric spatial sign cyclic correlation based fixed sample size and sequential detectors are proposed. Asymptotic distributions of the test statistics under the null hypothesis are established. A censoring scheme in which only informative test statistics are transmitted to the fusion center is proposed for collaborative detection. The proposed detectors and methods have the following benefits: employing cyclostationarity enables distinction among different systems, collaboration mitigates the effects of shadowing and multipath fading, using multiple strong cyclic frequencies improves the performance, robust detection provides reliable performance in heavy-tailed non-Gaussian noise, sequential detection reduces the average detection time, and censoring improves energy efficiency. In addition, a radar waveform recognition system for classifying common pulse compression waveforms is developed. The proposed supervised classification system classifies an intercepted radar pulse to one of eight different classes based on the pulse compression waveform: linear frequency modulation, Costas frequency codes, binary codes, as well as Frank, P1, P2, P3, and P4 polyphase codes. A robust M-estimation based method for radar emitter identification is proposed as well. A common modulation profile from a group of intercepted pulses is estimated and used for identifying the radar emitter. The M-estimation based approach provides robustness against preprocessing errors and deviations from the assumed noise model

Functional MRI data analysis : Detection, estimation and modelling

Ph.DDOCTOR OF PHILOSOPH

Assessment of a multi-measure functional connectivity approach

Efforts to find differences in brain activity patterns of subjects with neurological and psychiatric disorders that could help in their diagnosis and prognosis have been increasing in recent years and promise to revolutionise clinical practice and our understanding of such illnesses in the future. Resting-state functional magnetic resonance imaging (rsfMRI) data has been increasingly used to evaluate said activity and to characterize the connectivity between distinct brain regions, commonly organized in functional connectivity (FC) matrices. Here, machine learning methods were used to assess the extent to which multiple FC matrices, each determined with a different statistical method, could change classification performance relative to when only one matrix is used, as is common practice. Used statistical methods include correlation, coherence, mutual information, transfer entropy and non-linear correlation, as implemented in the MULAN toolbox. Classification was made using random forests and support vector machine (SVM) classifiers. Besides the previously mentioned objective, this study had three other goals: to individually investigate which of these statistical methods yielded better classification performances, to confirm the importance of the blood-oxygen-level-dependent (BOLD) signal in the frequency range 0.009-0.08 Hz for FC based classifications as well as to assess the impact of feature selection in SVM classifiers. Publicly available rs-fMRI data from the Addiction Connectome Preprocessed Initiative (ACPI) and the ADHD-200 databases was used to perform classification of controls vs subjects with Attention-Deficit/Hyperactivity Disorder (ADHD). Maximum accuracy and macro-averaged f-measure values of 0.744 and 0.677 were respectively achieved in the ACPI dataset and of 0.678 and 0.648 in the ADHD-200 dataset. Results show that combining matrices could significantly improve classification accuracy and macro-averaged f-measure if feature selection is made. Also, the results of this study suggest that mutual information methods might play an important role in FC based classifications, at least when classifying subjects with ADHD

Signal Processing Using Non-invasive Physiological Sensors

Non-invasive biomedical sensors for monitoring physiological parameters from the human body for potential future therapies and healthcare solutions. Today, a critical factor in providing a cost-effective healthcare system is improving patients' quality of life and mobility, which can be achieved by developing non-invasive sensor systems, which can then be deployed in point of care, used at home or integrated into wearable devices for long-term data collection. Another factor that plays an integral part in a cost-effective healthcare system is the signal processing of the data recorded with non-invasive biomedical sensors. In this book, we aimed to attract researchers who are interested in the application of signal processing methods to different biomedical signals, such as an electroencephalogram (EEG), electromyogram (EMG), functional near-infrared spectroscopy (fNIRS), electrocardiogram (ECG), galvanic skin response, pulse oximetry, photoplethysmogram (PPG), etc. We encouraged new signal processing methods or the use of existing signal processing methods for its novel application in physiological signals to help healthcare providers make better decisions

Machine Learning-based Predictive Maintenance for Optical Networks

Optical networks provide the backbone of modern telecommunications by connecting the world faster than ever before. However, such networks are susceptible to several failures (e.g., optical fiber cuts, malfunctioning optical devices), which might result in degradation in the network operation, massive data loss, and network disruption. It is challenging to accurately and quickly detect and localize such failures due to the complexity of such networks, the time required to identify the fault and pinpoint it using conventional approaches, and the lack of proactive efficient fault management mechanisms. Therefore, it is highly beneficial to perform fault management in optical communication systems in order to reduce the mean time to repair, to meet service level agreements more easily, and to enhance the network reliability. In this thesis, the aforementioned challenges and needs are tackled by investigating the use of machine learning (ML) techniques for implementing efficient proactive fault detection, diagnosis, and localization schemes for optical communication systems. In particular, the adoption of ML methods for solving the following problems is explored: - Degradation prediction of semiconductor lasers, - Lifetime (mean time to failure) prediction of semiconductor lasers, - Remaining useful life (the length of time a machine is likely to operate before it requires repair or replacement) prediction of semiconductor lasers, - Optical fiber fault detection, localization, characterization, and identification for different optical network architectures, - Anomaly detection in optical fiber monitoring. Such ML approaches outperform the conventionally employed methods for all the investigated use cases by achieving better prediction accuracy and earlier prediction or detection capability

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine