Modeling Overstock

Two main problems have been emerging in supply chain management: the increasing pressure to reduce working capital and the growing variety of products. Most of the popular indicators have been developed based on a controlled environment. A new indicator is now proposed, based on the uncertainty of the demand, the flexibility of the supply chains, the evolution of the products lifecycle and the fulfillment of a required service level. The model to support the indicator will be developed within the real options approach.overstock, stock management, real options

Challenges in forecasting uncertain product demand in supply chain: A systematic literature review

Forecasting for uncertain product demand in supply chain is challenging and statistical models alone cannot overcome the challenges faced. Our overall objective is to explore the challenges faced in forecasting uncertain product demand and examine extant literature by synthesizing the results of studies that have empirically investigated this complex phenomenon. We performed a Systematic Literature Review (SLR) following the well-known guidelines of the evidence-based paradigm which resulted in selecting 66 empirical studies. Our results are presented into two categories of internal and external challenges: 24 of the 66 studies express internal challenges, whilst 13 studies report external challenges, and 8 studies cover both internal and external challenges. We also present significant gaps identified in the research literatur

Modeling Overstock

Two main problems have been emerging in supply chain management: the increasing pressure to reduce working capital and the growing variety of products. Most of the popular indicators have been developed based on a controlled environment. A new indicator is now proposed, based on the uncertainty of the demand, the flexibility of the supply chains, the evolution of the products lifecycle and the fulfillment of a required service level. The model to support the indicator will be developed within the real options approach

Supply chain management of blood products: a literature review.

This paper presents a review of the literature on inventory and supply chain management of blood products. First, we identify different perspectives on approaches to classifying the existing material. Each perspective is presented as a table in which the classification is displayed. The classification choices are exemplified through the citation of key references or by expounding the features of the perspective. The main contribution of this review is to facilitate the tracing of published work in relevant fields of interest, as well as identifying trends and indicating which areas should be subject to future research.OR in health services; Supply chain management; Inventory; Blood products; Literature review;

Integrating demand uncertainty in inventory routing for recyclable waste collection

Osteoblast cell adhesion to the extracellular matrix is established through two main pathways: one is mediated by the binding between integrin and a minimal adhesion sequence (RGD) on the extracellular protein, the other is based on the interactions between transmembrane proteoglycans and heparin-binding sequences found in many matrix proteins. The aim of this study is the evaluation in an in vivo endosseous implant model of the early osteogenic response of the peri-implant bone to a biomimetic titanium surface functionalized with the retro-inverso 2DHVP peptide, an analogue of Vitronectin heparin binding site. The experimental plan is based on a bilateral study design of Control and 2DHVP implants inserted respectively in the right and left femur distal metaphysis of adult male Wistar rats (n=16) weighing about 300 gr and evaluated after 15 days. Fluorochromic bone vital markers, were given at specific time frame, in order to monitor the dynamic of new bone deposition. The effect inducted by the peptidomimetic coating on the surrounding bone were qualitatively and quantitatively evaluated by means of static and dynamic histomorphometric analyses performed within three concentric and subsequent circular Regions of Interest (ROI) of equivalent thickness (220 μm), ROI1 adjacent to the interface, ROI2, the middle, and ROI3 the farthest. The data indicated that these functionalized implants stimulated a higher bone apposition rate (p<0,01) and larger and rapid osteoblast activation in terms of mineralising surface within ROI1 compared to the Control (p<0,01). These higher osteoblast recruitment and activation leads to a greater bone to implant contact reached for DHVP samples (p<0,5). This represents an initial stimulus of the osteogenic activity that might results in a faster and better osteointegration process