Research in progress--LungSEARCH: a randomised controlled trial of surveillance for the early detection of lung cancer in a high-risk group.

UNLABELLED: Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals (ie, current or former moderate to heavy smokers with mild/moderate COPD) who undergo either annual sputum cytology/cytometry testing or no screening. Those with abnormal sputum then receive annual CT and fluorescent bronchoscopy for the remainder of 5 years, to identify early stage lung cancer. It is hoped that these simple initial tests could identify those requiring expensive CT scans, and the aim is to demonstrate a stage shift towards early stage cancers.Trial registration numbers ISRCTN: ISRCTN80745975, clinicaltrials.gov: NCT00512746

Of Punctuation and Parentage

As is well known, when the words of the Book of Mormon were translated “by the gift and power of God,” there was no punctuation at all in the early manuscripts, and that is the way the translated text was delivered to E. B. Grandin’s print shop. Type-setter John Gilbert reported that when he sat down to prepare the text for publication, “every chapter . . . was one solid paragraph, without a punctuation mark, from beginning to end.”¹ So he added punctuation and paragraphing as he went along. He did a good job, especially for someone reading the book for the first time, but there are a few sentences that could have been punctuated in more than one way, with slightly different results. Since the punctuation of the Book of Mormon does not enjoy the same revealed status as the words themselves, it may be worth considering some of the alternatives

Research update, Fall 2019

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