PnP-AdaNet: Plug-and-Play Adversarial Domain Adaptation Network with a Benchmark at Cross-modality Cardiac Segmentation

Deep convolutional networks have demonstrated the state-of-the-art performance on various medical image computing tasks. Leveraging images from different modalities for the same analysis task holds clinical benefits. However, the generalization capability of deep models on test data with different distributions remain as a major challenge. In this paper, we propose the PnPAdaNet (plug-and-play adversarial domain adaptation network) for adapting segmentation networks between different modalities of medical images, e.g., MRI and CT. We propose to tackle the significant domain shift by aligning the feature spaces of source and target domains in an unsupervised manner. Specifically, a domain adaptation module flexibly replaces the early encoder layers of the source network, and the higher layers are shared between domains. With adversarial learning, we build two discriminators whose inputs are respectively multi-level features and predicted segmentation masks. We have validated our domain adaptation method on cardiac structure segmentation in unpaired MRI and CT. The experimental results with comprehensive ablation studies demonstrate the excellent efficacy of our proposed PnP-AdaNet. Moreover, we introduce a novel benchmark on the cardiac dataset for the task of unsupervised cross-modality domain adaptation. We will make our code and database publicly available, aiming to promote future studies on this challenging yet important research topic in medical imaging

Privacy Preserving Domain Adaptation for Semantic Segmentation of Medical Images

Convolutional neural networks (CNNs) have led to significant improvements in tasks involving semantic segmentation of images. CNNs are vulnerable in the area of biomedical image segmentation because of distributional gap between two source and target domains with different data modalities which leads to domain shift. Domain shift makes data annotations in new modalities necessary because models must be retrained from scratch. Unsupervised domain adaptation (UDA) is proposed to adapt a model to new modalities using solely unlabeled target domain data. Common UDA algorithms require access to data points in the source domain which may not be feasible in medical imaging due to privacy concerns. In this work, we develop an algorithm for UDA in a privacy-constrained setting, where the source domain data is inaccessible. Our idea is based on encoding the information from the source samples into a prototypical distribution that is used as an intermediate distribution for aligning the target domain distribution with the source domain distribution. We demonstrate the effectiveness of our algorithm by comparing it to state-of-the-art medical image semantic segmentation approaches on two medical image semantic segmentation datasets