140 research outputs found
Is attention all you need in medical image analysis? A review
Medical imaging is a key component in clinical diagnosis, treatment planning
and clinical trial design, accounting for almost 90% of all healthcare data.
CNNs achieved performance gains in medical image analysis (MIA) over the last
years. CNNs can efficiently model local pixel interactions and be trained on
small-scale MI data. The main disadvantage of typical CNN models is that they
ignore global pixel relationships within images, which limits their
generalisation ability to understand out-of-distribution data with different
'global' information. The recent progress of Artificial Intelligence gave rise
to Transformers, which can learn global relationships from data. However, full
Transformer models need to be trained on large-scale data and involve
tremendous computational complexity. Attention and Transformer compartments
(Transf/Attention) which can well maintain properties for modelling global
relationships, have been proposed as lighter alternatives of full Transformers.
Recently, there is an increasing trend to co-pollinate complementary
local-global properties from CNN and Transf/Attention architectures, which led
to a new era of hybrid models. The past years have witnessed substantial growth
in hybrid CNN-Transf/Attention models across diverse MIA problems. In this
systematic review, we survey existing hybrid CNN-Transf/Attention models,
review and unravel key architectural designs, analyse breakthroughs, and
evaluate current and future opportunities as well as challenges. We also
introduced a comprehensive analysis framework on generalisation opportunities
of scientific and clinical impact, based on which new data-driven domain
generalisation and adaptation methods can be stimulated
Disentangled Autoencoder for Cross-Stain Feature Extraction in Pathology Image Analysis
A novel deep autoencoder architecture is proposed for the analysis of histopathology images. Its purpose is to produce a disentangled latent representation in which the structure and colour information are confined to different subspaces so that stain-independent models may be learned. For this, we introduce two constraints on the representation which are implemented as a classifier and an adversarial discriminator. We show how they can be used for learning a latent representation across haematoxylin-eosin and a number of immune stains. Finally, we demonstrate the utility of the proposed representation in the context of matching image patches for registration applications and for learning a bag of visual words for whole slide image summarization
Learning Disentangled Representations in the Imaging Domain
Disentangled representation learning has been proposed as an approach to
learning general representations even in the absence of, or with limited,
supervision. A good general representation can be fine-tuned for new target
tasks using modest amounts of data, or used directly in unseen domains
achieving remarkable performance in the corresponding task. This alleviation of
the data and annotation requirements offers tantalising prospects for
applications in computer vision and healthcare. In this tutorial paper, we
motivate the need for disentangled representations, present key theory, and
detail practical building blocks and criteria for learning such
representations. We discuss applications in medical imaging and computer vision
emphasising choices made in exemplar key works. We conclude by presenting
remaining challenges and opportunities.Comment: Submitted. This paper follows a tutorial style but also surveys a
considerable (more than 200 citations) number of work
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