Calibrated Multivariate Regression with Application to Neural Semantic Basis Discovery

We propose a calibrated multivariate regression method named CMR for fitting high dimensional multivariate regression models. Compared with existing methods, CMR calibrates regularization for each regression task with respect to its noise level so that it simultaneously attains improved finite-sample performance and tuning insensitiveness. Theoretically, we provide sufficient conditions under which CMR achieves the optimal rate of convergence in parameter estimation. Computationally, we propose an efficient smoothed proximal gradient algorithm with a worst-case numerical rate of convergence \cO(1/\epsilon), where $\epsilon$ is a pre-specified accuracy of the objective function value. We conduct thorough numerical simulations to illustrate that CMR consistently outperforms other high dimensional multivariate regression methods. We also apply CMR to solve a brain activity prediction problem and find that it is as competitive as a handcrafted model created by human experts. The R package \texttt{camel} implementing the proposed method is available on the Comprehensive R Archive Network \url{http://cran.r-project.org/web/packages/camel/}.Comment: Journal of Machine Learning Research, 201

Ultra-high Dimensional Multiple Output Learning With Simultaneous Orthogonal Matching Pursuit: A Sure Screening Approach

We propose a novel application of the Simultaneous Orthogonal Matching Pursuit (S-OMP) procedure for sparsistant variable selection in ultra-high dimensional multi-task regression problems. Screening of variables, as introduced in \cite{fan08sis}, is an efficient and highly scalable way to remove many irrelevant variables from the set of all variables, while retaining all the relevant variables. S-OMP can be applied to problems with hundreds of thousands of variables and once the number of variables is reduced to a manageable size, a more computationally demanding procedure can be used to identify the relevant variables for each of the regression outputs. To our knowledge, this is the first attempt to utilize relatedness of multiple outputs to perform fast screening of relevant variables. As our main theoretical contribution, we prove that, asymptotically, S-OMP is guaranteed to reduce an ultra-high number of variables to below the sample size without losing true relevant variables. We also provide formal evidence that a modified Bayesian information criterion (BIC) can be used to efficiently determine the number of iterations in S-OMP. We further provide empirical evidence on the benefit of variable selection using multiple regression outputs jointly, as opposed to performing variable selection for each output separately. The finite sample performance of S-OMP is demonstrated on extensive simulation studies, and on a genetic association mapping problem. $Keywords$ Adaptive Lasso; Greedy forward regression; Orthogonal matching pursuit; Multi-output regression; Multi-task learning; Simultaneous orthogonal matching pursuit; Sure screening; Variable selectio

Conditioning of Random Block Subdictionaries with Applications to Block-Sparse Recovery and Regression

The linear model, in which a set of observations is assumed to be given by a linear combination of columns of a matrix, has long been the mainstay of the statistics and signal processing literature. One particular challenge for inference under linear models is understanding the conditions on the dictionary under which reliable inference is possible. This challenge has attracted renewed attention in recent years since many modern inference problems deal with the "underdetermined" setting, in which the number of observations is much smaller than the number of columns in the dictionary. This paper makes several contributions for this setting when the set of observations is given by a linear combination of a small number of groups of columns of the dictionary, termed the "block-sparse" case. First, it specifies conditions on the dictionary under which most block subdictionaries are well conditioned. This result is fundamentally different from prior work on block-sparse inference because (i) it provides conditions that can be explicitly computed in polynomial time, (ii) the given conditions translate into near-optimal scaling of the number of columns of the block subdictionaries as a function of the number of observations for a large class of dictionaries, and (iii) it suggests that the spectral norm and the quadratic-mean block coherence of the dictionary (rather than the worst-case coherences) fundamentally limit the scaling of dimensions of the well-conditioned block subdictionaries. Second, this paper investigates the problems of block-sparse recovery and block-sparse regression in underdetermined settings. Near-optimal block-sparse recovery and regression are possible for certain dictionaries as long as the dictionary satisfies easily computable conditions and the coefficients describing the linear combination of groups of columns can be modeled through a mild statistical prior.Comment: 39 pages, 3 figures. A revised and expanded version of the paper published in IEEE Transactions on Information Theory (DOI: 10.1109/TIT.2015.2429632); this revision includes corrections in the proofs of some of the result

Group Lasso with Overlaps: the Latent Group Lasso approach

We study a norm for structured sparsity which leads to sparse linear predictors whose supports are unions of prede ned overlapping groups of variables. We call the obtained formulation latent group Lasso, since it is based on applying the usual group Lasso penalty on a set of latent variables. A detailed analysis of the norm and its properties is presented and we characterize conditions under which the set of groups associated with latent variables are correctly identi ed. We motivate and discuss the delicate choice of weights associated to each group, and illustrate this approach on simulated data and on the problem of breast cancer prognosis from gene expression data