1,238 research outputs found

    Closing the sea surface mixed layer temperature budget from in situ observations alone: Operation Advection during BoBBLE

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    Sea surface temperature (SST) is a fundamental driver of tropical weather systems such as monsoon rainfall and tropical cyclones. However, understanding of the factors that control SST variability is lacking, especially during the monsoons when in situ observations are sparse. Here we use a ground-breaking observational approach to determine the controls on the SST variability in the southern Bay of Bengal. We achieve this through the first full closure of the ocean mixed layer energy budget derived entirely from in situ observations during the Bay of Bengal Boundary Layer Experiment (BoBBLE). Locally measured horizontal advection and entrainment contribute more significantly than expected to SST evolution and thus oceanic variability during the observation period. These processes are poorly resolved by state-of-the-art climate models, which may contribute to poor representation of monsoon rainfall variability. The novel techniques presented here provide a blueprint for future observational experiments to quantify the mixed layer heat budget on longer time scales and to evaluate these processes in models

    2. Wochenbericht M97

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    Meteor Reise 97: Sauerstoffzufuhr-Tracer-Ausbringungsexperiment SFB754 2. Wochenbericht der Meteorreise M97 Mindelo (Kapverden) – Fortaleza (Brasilien), 25 Mai – 28 Juni 201

    CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

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    The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients. Further studies are needed to investigate the role of CXCL4 assessment in UCTD-risk-SSc

    Treatment of Undifferentiated Connective Tissue Disease by Primary Care Providers Using csDMARDs

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    •Undifferentiated connective tissue disease (UCTD) is an autoimmune disease that presents similarly to other rheumatic conditions but fails to meet laboratory requirements which indicate a specific disease such as rheumatoid arthritis, systemic lupus erythematous, Sjogren\u27s or scleroderma. •UCTD presentation can include arthralgias, myalgias, fatigue, fever, Raynaud’s phenomenon and sicca like symptoms with a positive antinuclear antibody (ANA) test. •Patients with UCTD symptoms are normally referred to rheumatology but a shortage exists leaving primary care providers to treat UCTD patients. •Using disease modifying antirheumatic drugs (DMARDs) such as hydroxychloroquine is an option but it is not commonly prescribed by PCPs. •The study’s purpose is to determine if PCPs can effectively initiate and appropriately manage UCTD patients using DMARDs, such as hydroxychloroquine, to reduce the patient’s symptoms and functional impairment. •Using DMARDs, NSAIDs and low dose corticosteroids in UCTD patients provided by PCPs can improve arthralgias, myalgias, fever, and functional limitations. •Majority of rheumatologists and PCPs feel UCTD patients should be referred to rheumatology for treatment, yet there is some evidence that PCPs can also initiate and manage the treatment effectively. •In the absence of rheumatology, PCPs using DMARDs such as hydroxychloroquine can safely and effectively provide treatment for these patientshttps://commons.und.edu/pas-grad-posters/1000/thumbnail.jp

    Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

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    Undifferentiated connective tissue disease (UCTD) is a distinct clinical entity that may be accompanied by interstitial lung disease (ILD). The natural history of UCTD-ILD is unknown. We hypothesized that patients with UCTD-ILD would be more likely to have improvement in lung function than those with idiopathic pulmonary fibrosis (IPF) during longitudinal follow-up. We identified subjects enrolled in the UCSF ILD cohort study with a diagnosis of IPF or UCTD. The primary outcome compared the presence or absence of a ≥5% increase in percent predicted forced vital capacity (FVC) in IPF and UCTD. Regression models were used to account for potential confounding variables. Ninety subjects were identified; 59 subjects (30 IPF, 29 UCTD) had longitudinal pulmonary function data for inclusion in the analysis. After accounting for baseline pulmonary function tests, treatment, and duration between studies, UCTD was associated with substantial improvement in FVC (odds ratio = 8.23, 95% confidence interval, 1.27–53.2; p = 0.03) during follow-up (median, 8 months) compared with IPF. Patients with UCTD-ILD are more likely to have improved pulmonary function during follow-up than those with IPF. These findings demonstrate the clinical importance of identifying UCTD in patients presenting with an “idiopathic” interstitial pneumonia

    Cruise Report RV POSEIDON Cruise P468 [POS468]

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    Portimão – Bari 03. April – 28. April 201

    Hydrography in the Mediterranean Sea during a cruise with RV Poseidon in April 2014

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    We report on data from an oceanographic cruise in the Mediterranean Sea on the German research vessel Poseidon in April 2014. Data were taken on a west–east section, starting at the Strait of Gibraltar and ending south-east of Crete, as well on sections in the Ionian and Adriatic Sea. The objectives of the cruise were threefold: to contribute to the investigation of the spatial evolution of the Levantine Intermediate Water (LIW) properties and of the deep water masses in the eastern Mediterranean Sea, and to investigate the mesoscale variability of the upper water column. The measurements include salinity, temperature, oxygen and currents and were conducted with a conductivity, temperature and depth(CTD)/rosette system, an underway CTD and an acoustic Doppler current profiler (ADCP). The sections are on tracks which have been sampled during several other cruises, thus supporting the opportunity to investigate the long-term temporal development of the different variables. The use of an underway CTD made it possible to conduct measurements of temperature and salinity with a high horizontal spacing of 6 nm between stations and a vertical spacing of 1 dbar for the upper 800 m of the water column

    Current-eddy interaction in the Agulhas Return Current region from the seismic oceanography perspective

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    Interleaving in the Agulhas Return Current (ARC) frontal region is commonly manifested in the form of thermohaline intrusions, as sub-tropical and sub-polar water masses of similar density meet. In Jan/Feb 2012, the Naval Research Laboratory and collaborators carried out a field experiment in which seismic and traditional hydrographic observations were acquired to examine frontal zone mixing processes. The high lateral resolution (10 m) of the seismic observations allowed fine-scale lateral tracking of thermal intrusions, which were corroborated with simultaneous XBT casts. Between seismic deployments both salinity and temperature data were acquired via CTD, Underway-CTD and microstructure profiles. This study focuses on analyzing seismic reflection data in a particular E-W transect where the northward flowing ARC interacted with the southward flowing portion of a large anticyclonic eddy. Strong reflectors were most prominent at the edge of a hyperbolic zone formed between the eddy and ARC, where sub-polar waters interacted with waters of sub-tropical origin on either side. Reflectors were shallow within the hyperbolic zone and extended to 1200 m below the ARC. The nature of the observed reflectors will be determined from comparison of seismic reflection and derived ∂T/∂z fields, and XBT and TS profiles from the available hydrographic data

    Treatment of Undifferentiated Connective Tissue Disease with csDMARD’s through Primary Care Providers in the Absence of Intervention via Rheumatology

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    Undifferentiated connective tissue disease (UCTD) was first defined by Leroy over 30 years ago. UCTD is described as an autoimmune disease which presents similarly to other rheumatic diseases but fails to meet laboratory requirements which indicate a specific disease such as rheumatoid arthritis, systemic lupus erythematous, Sjogren\u27s or scleroderma. Common signs and symptoms manifested by patients with UCTD include arthralgias, myalgias, fatigue, fever, Raynaud’s phenomenon and sicca like symptoms in addition to having a positive antinuclear antibody (ANA) test. Often patients with these symptoms are referred to rheumatology. Unfortunately, there is a shortage of rheumatology providers across the nation. Although patients with UCTD have limited access to rheumatologists, there may be room for primary care providers to safely and adequately treat their symptoms with the use of disease modifying antirheumatic drugs (DMARDs) such as hydroxychloroquine. Evidence exists from recent studies that support the use of DMARDs, NSAIDs and low dose corticosteroids in UCTD patients to improve arthralgias, myalgias, fever, and functional limitations. Although the research indicates that the majority of rheumatologists and primary care providers feel UCTD patients should be referred to rheumatology, there is some evidence that primary care providers can also initiate and manage the treatment of UCTD patients. In the absence of rheumatology, primary care providers familiar with using DMARDs such as hydroxychloroquine can safely and effectively provide treatment for these patients
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