Motor deficits are produced by removing some cortical transplants grafted into injured sensorimotor cortex of neonatal rats.

Fetal frontal cortex was transplanted into cavities formed in the right motor cortex of neonatal rats. As adults, the animals were trained to press two levers in rapid succession with their left forelimb to receive food rewards. Once they had reached an optimal level of performance, the effect of removing their transplants was assessed. Surgical removal of transplants significantly impaired the performance of 2 of 4 subjects. Placing a cross-strain skin graft to induce the immunological rejection of the transplants produced a behavioral deficit in 1 of 2 subjects with complete transplant removal. Skin grafts produced no behavioral effects in four subjects that had surviving transplants. Since the motor deficits produced by transplant removal resembled those observed following the removal of normal motor cortex, we propose that these three transplants functioned within the host brain. Histology showed that the procedures used to remove cortical grafts did not injure any host brains. Therefore, host brain damage is unlikely to account for the behavioral deterioration that followed transplant removals

Cadaveric vs. Live-Donor Kidney Transplants: The Interaction of Institutions and Inequality

In 1991, the World Health Assembly approved a set of Guiding Principles which emphasize voluntary donation, non-commercialization and a preference for cadavers over living donors” (World Health Organization). We investigate whether factors such as inequality, rule of law and religion have any effect on the ratio of cadaveric transplants to all transplants. Using an unbalanced annual dataset from 64 countries over 1993-2004, we show particularly for developing countries that an improvement in equality and rule of law encourage cadaveric kidney transplants. Religion also plays an important role in that relationship.Cadaveric and live-donor kidney transplants, rule of law, religious beliefs, inequality

Perceptions of HIV-positive kidney donations to HIV-positive recipients

BACKGROUND: Kidney transplantation is the preferred standard of care for patients who have both end stage renal disease (ESRD) and human immunodeficiency virus (HIV) infection. The first successful kidney transplant was done in 1954 and the first case of HIV/AIDS occurred in 1981. Until recently, HIV-positive patients who required an organ transplant received an HIV-negative organ because it was illegal to use HIV-positive organs in transplants in the United States. The HIV Organ Policy Equity (HOPE) Act was signed in 2013 and legalized the use of HIV-positive donor organs in organ transplants. The first of these transplants was completed in March 2016 with good results. LITERATURE REVIEW: Renal transplants have lower mortality than dialysis. HIV damages the kidney in multiple ways, including HIV associated nephropathy and HIV immune complex kidney disease, putting HIV patients at higher risk of ESRD. Studies from before the utilization of anti-retroviral therapy show that transplantation of HIV infected blood or organs do not cause failure of the transplanted organ. However, in 1997 most surgeons would not transplant kidneys to HIV-infected individuals. Success of antiretroviral therapy has allowed HIV patients to live longer, but patients experience complications including end organ damage. Providing transplants to ESRD patients with HIV infection has been preferred treatment since 2010. Due to improvements in both HIV and transplant science, transplant specialists today are likely to accept HIV-positive organs to HIV-positive transplant recipients. PROPOSED PROJECT: The proposed study is a survey of United States transplant professionals to determine their perceptions about these transplants. Researchers will collect data in the form of Likert scales as well as open-ended responses. The survey will also collect demographic information about surveyors. Investigators will then analyze the collected data for professional knowledge of the legal change, perceptions of efficacy and safety, and concerns. Researchers will analyze the data both as a whole and divided by demographic subgroups. CONCLUSIONS: To date, there has been no study that has assessed at the attitudes of the medical community involved in these transplants. This study is unique in that it attempts to obtain the perceptions and concerns the transplant specialists have about HIV-positive donor organs to HIV-positive transplant recipients. SIGNIFICANCE: The data from this study will help to establish what opinions are at this time, to determine if there are any regional discrepancies that may affect patient access to care, and to determine the concerns of transplant specialists at this time

Tissue typing by unidirectional mixed lymphocyte culture. 3. The relationship of in vitro lymphocyte compatibility to renal allograft rejection

We applied unidirectional MLC test to renal allograft in dogs, and investigated the correlation between the growth rates of MLC reaction and the intensity of rejection of the kidney transplants or the postoperative renal function. It was concluded that the grade of rejection became three plus (+ + +) when the rate of blastformation was more than 18 %, while it became one plus when the rate was less than 15 %. The rate of blast. formation was closely correlated with the strength of rejection of kidney transplants. However, the postoperative renal function was not always correlated with the mixed lymphocyte reaction.</p

Outcome of renal grafts after simultaneous kidney/ pancreas transplantation

Nineteen patients with endstage renal failure due to Type 1 (insulin-dependent) diabetes mellitus received simultaneous pancreas/kidney transplants using bladder drainage technique. Another group of 25 Type 1 diabetic patients received pancreas/kidney transplants by the duct occlusion technique. We observed a higher incidence of rejection episodes in the patients of the bladder drainage group than those in the duct occlusion group, 14 of 19 patients (74%) vs 7 of 25 (28%) respectively. Anti CD3 antibodies (Orthoclone, OKT3) as a part of induction treatment was used more often in the bladder drainage group (58%) than in the control group (20%)

Paired and altruistic kidney donation in the UK: Algorithms and experimentation

We study the computational problem of identifying optimal sets of kidney exchanges in the UK. We show how to expand an integer programming-based formulation due to Roth et al. [2007] in order to model the criteria that constitute the UK definition of optimality. The software arising from this work has been used by the National Health Service Blood and Transplant to find optimal sets of kidney exchanges for their National Living Donor Kidney Sharing Schemes since July 2008. We report on the characteristics of the solutions that have been obtained in matching runs of the scheme since this time. We then present empirical results arising from experiments on the real datasets that stem from these matching runs, with the aim of establishing the extent to which the particular optimality criteria that are present in the UK influence the structure of the solutions that are ultimately computed. A key observation is that allowing four-way exchanges would be likely to lead to a moderate number of additional transplants

Institutional Transplants in the Transformation of Poland's Economy and Polity

The collapse of communism faced Poland and other former Soviet bloc countries with the need for a massive “institutional refit”, as regards both economic and political institutions. This paper describes where some of the key new institutions were derived from (either in the form of transplants from other countries, revivals of pre-communist domestic institutions or completely new local “institutional innovations”), and proposes some tentative views as to why the particular developments we observe took place, and whether they corresponded to needs at the time. In the case of transplants, we attempt to explain why these were copied from one particular country rather than from others.Institutional economics, institutional transplants, legal systems, transition,Poland

Pseudomonas aeruginosa bacteremia in patients undergoing liver transplantation: An emerging problem

In our institution, Pseudomonas aeruginosa bacteremia appeared to occur with increasing frequency in patients undergoing liver transplantation. We thus conducted a prospective study to define risk factors and outcome in these patients. Over a 19-month period 6% of liver transplants were followed by Pseudomonas bacteremia. The mean age was 46 years (range, 24 to 67 years). The interval between transplantation and onset of bacteremia was 3 to 372 days (mean, 80). The incidence of Pseudomonas bacteremia in liver transplants was three times that of other transplants (heart, lung, kidney). Ninety one percent of infections were nosocomial. Polymicrobial bacteremia occurred in 30% of episodes. The portal of entry was respiratory in 30%, abdominal in 35%, and biliary in 13%. Four patients had recurrent Pseudomonas bacteremia: liver abscess (1), biliary obstruction (2), subhepatic abscess (1). Survival at 14 days was 70%. Survival rates were significantly lower for patients with hypotension, on mechanical ventilators, and increasing severity of illness (p < 0.05). Survival was higher when bacteremia occurred within the first 30 days after transplantation compared to after 30 days. A large number (43.4%) of Pseudomonas bacteremias occurred after transplant surgery or biliary tract manipulation, while the patient was receiving a prophylactic regimen of cefotaxime and ampicillin. P. aeruginosa is an important pathogen in the liver transplant recipient; prevention may be possible for a subgroup of patients with the use of prophylactic antibiotics with activity against P. aeruginosa