2 research outputs found
Automatic Segmentation, Feature Extraction and Comparison of Healthy and Stroke Cerebral Vasculature
Accurate segmentation of cerebral vasculature and a quantitative assessment
of cerebrovascular morphology is critical to various diagnostic and therapeutic
purposes and is pertinent to studying brain health and disease. However, this
is still a challenging task due to the complexity of the vascular imaging data.
We propose an automated method for cerebral vascular segmentation without the
need of any manual intervention as well as a method to skeletonize the binary
volume to extract vascular geometric features which can characterize vessel
structure. We combine a probabilistic vessel-enhancing filtering with an
active-contour technique to segment magnetic resonance and computed tomography
angiograms (MRA and CTA) and subsequently extract the vessel centerlines and
diameters to calculate the geometrical properties of the vasculature. Our
method was validated using a 3D phantom of the Circle-of-Willis region with 84%
mean Dice Similarity and 85% mean Pearson Correlation with minimal modified
Hausdorff distance error. We applied this method to a dataset of healthy
subjects and stroke patients and present a quantitative comparison between
them. We found significant differences in the geometric features including
total length (2.88 +/- 0.38 m for healthy and 2.20 +/- 0.67 m for stroke),
volume (40.18 +/- 25.55 ml for healthy and 34.43 +/- 21.83 ml for stroke),
tortuosity (3.24 +/- 0.88 rad/cm for healthy and 5.80 +/- 0.92 rad/cm for
stroke) and fractality (box dimension 1.36 +/- 0.28 for healthy vs. 1.69 +/-
0.20 for stroke). This technique can be applied on any imaging modality and can
be used in the future to automatically obtain the 3D segmented vasculature for
diagnosis and treatment planning of Stroke and other cerebrovascular diseases
(CVD) in the clinic and also to study the morphological changes caused by
various CVD.Comment: 14 pages, 4 figures, 4 table
Learning-Based Algorithms for Vessel Tracking: A Review
Developing efficient vessel-tracking algorithms is crucial for imaging-based
diagnosis and treatment of vascular diseases. Vessel tracking aims to solve
recognition problems such as key (seed) point detection, centerline extraction,
and vascular segmentation. Extensive image-processing techniques have been
developed to overcome the problems of vessel tracking that are mainly
attributed to the complex morphologies of vessels and image characteristics of
angiography. This paper presents a literature review on vessel-tracking
methods, focusing on machine-learning-based methods. First, the conventional
machine-learning-based algorithms are reviewed, and then, a general survey of
deep-learning-based frameworks is provided. On the basis of the reviewed
methods, the evaluation issues are introduced. The paper is concluded with
discussions about the remaining exigencies and future research.Comment: 19 pages, 3 figures, 9 tables, accept by Computerized Medical Imaging
and Graphic