28,544 research outputs found
Elastic Registration of Geodesic Vascular Graphs
Vascular graphs can embed a number of high-level features, from morphological
parameters, to functional biomarkers, and represent an invaluable tool for
longitudinal and cross-sectional clinical inference. This, however, is only
feasible when graphs are co-registered together, allowing coherent multiple
comparisons. The robust registration of vascular topologies stands therefore as
key enabling technology for group-wise analyses. In this work, we present an
end-to-end vascular graph registration approach, that aligns networks with
non-linear geometries and topological deformations, by introducing a novel
overconnected geodesic vascular graph formulation, and without enforcing any
anatomical prior constraint. The 3D elastic graph registration is then
performed with state-of-the-art graph matching methods used in computer vision.
Promising results of vascular matching are found using graphs from synthetic
and real angiographies. Observations and future designs are discussed towards
potential clinical applications
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
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