Extending Active Shape Models to Incorporate a-priori Knowledge about Structural Variability

A new deformable shape model is defined with the following properties: (1) A-priori knowledge describes shapes not only by statistical variation of a fixed structure like active shape/appearance model but also by variability of structure using a production system. (2) Multi-resolution description of shape structures enable more constrained statistical variation of shape as the model evolves in fitting the data. (3) It enables comparison between different shapes as well as characterizing and reconstructing instances of the same shape. Experiments on simulated 2D shapes demonstrate the ability of the algorithm to find structures of different shapes and also to characterize the statistical variability between instances of the same shape

Bi-temporal 3D active appearance models with applications to unsupervised ejection fraction estimation

Rapid and unsupervised quantitative analysis is of utmost importance to ensure clinical acceptance of many examinations using cardiac magnetic resonance imaging (MRI). We present a framework that aims at fulfilling these goals for the application of left ventricular ejection fraction estimation in four-dimensional MRI. The theoretical foundation of our work is the generative two-dimensional Active Appearance Models by Cootes et al., here extended to bi-temporal, three-dimensional models. Further issues treated include correction of respiratory induced slice displacements, systole detection, and a texture model pruning strategy. Cross-validation carried out on clinical-quality scans of twelve volunteers indicates that ejection fraction and cardiac blood pool volumes can be estimated automatically and rapidly with accuracy on par with typical inter-observer variability. \u

FAME - A Flexible Appearance Modelling Environment

Combined modelling of pixel intensities and shape has proven to be a very robust and widely applicable approach to interpret images. As such the Active Appearance Model (AAM) framework has been applied to a wide variety of problems within medical image analysis. This paper summarises AAM applications within medicine and describes a public domain implementation, namely the Flexible Appearance Modelling Environment (FAME). We give guidelines for the use of this research platform, and show that the optimisation techniques used renders it applicable to interactive medical applications. To increase performance and make models generalise better, we apply parallel analysis to obtain automatic and objective model truncation. Further, two different AAM training methods are compared along with a reference case study carried out on cross-sectional short-axis cardiac magnetic resonance images and face images. Source code and annotated data sets needed to reproduce the results are put in the public domain for further investigation