Efficient transfer entropy analysis of non-stationary neural time series

Information theory allows us to investigate information processing in neural systems in terms of information transfer, storage and modification. Especially the measure of information transfer, transfer entropy, has seen a dramatic surge of interest in neuroscience. Estimating transfer entropy from two processes requires the observation of multiple realizations of these processes to estimate associated probability density functions. To obtain these observations, available estimators assume stationarity of processes to allow pooling of observations over time. This assumption however, is a major obstacle to the application of these estimators in neuroscience as observed processes are often non-stationary. As a solution, Gomez-Herrero and colleagues theoretically showed that the stationarity assumption may be avoided by estimating transfer entropy from an ensemble of realizations. Such an ensemble is often readily available in neuroscience experiments in the form of experimental trials. Thus, in this work we combine the ensemble method with a recently proposed transfer entropy estimator to make transfer entropy estimation applicable to non-stationary time series. We present an efficient implementation of the approach that deals with the increased computational demand of the ensemble method's practical application. In particular, we use a massively parallel implementation for a graphics processing unit to handle the computationally most heavy aspects of the ensemble method. We test the performance and robustness of our implementation on data from simulated stochastic processes and demonstrate the method's applicability to magnetoencephalographic data. While we mainly evaluate the proposed method for neuroscientific data, we expect it to be applicable in a variety of fields that are concerned with the analysis of information transfer in complex biological, social, and artificial systems.Comment: 27 pages, 7 figures, submitted to PLOS ON

Beyond Triangles: A Distributed Framework for Estimating 3-profiles of Large Graphs

We study the problem of approximating the $3$-profile of a large graph. $3$-profiles are generalizations of triangle counts that specify the number of times a small graph appears as an induced subgraph of a large graph. Our algorithm uses the novel concept of $3$-profile sparsifiers: sparse graphs that can be used to approximate the full $3$-profile counts for a given large graph. Further, we study the problem of estimating local and ego $3$-profiles, two graph quantities that characterize the local neighborhood of each vertex of a graph. Our algorithm is distributed and operates as a vertex program over the GraphLab PowerGraph framework. We introduce the concept of edge pivoting which allows us to collect $2$-hop information without maintaining an explicit $2$-hop neighborhood list at each vertex. This enables the computation of all the local $3$-profiles in parallel with minimal communication. We test out implementation in several experiments scaling up to $640$ cores on Amazon EC2. We find that our algorithm can estimate the $3$-profile of a graph in approximately the same time as triangle counting. For the harder problem of ego $3$-profiles, we introduce an algorithm that can estimate profiles of hundreds of thousands of vertices in parallel, in the timescale of minutes.Comment: To appear in part at KDD'1

Distributed Estimation of Graph 4-Profiles

We present a novel distributed algorithm for counting all four-node induced subgraphs in a big graph. These counts, called the $4$-profile, describe a graph's connectivity properties and have found several uses ranging from bioinformatics to spam detection. We also study the more complicated problem of estimating the local $4$-profiles centered at each vertex of the graph. The local $4$-profile embeds every vertex in an $11$-dimensional space that characterizes the local geometry of its neighborhood: vertices that connect different clusters will have different local $4$-profiles compared to those that are only part of one dense cluster. Our algorithm is a local, distributed message-passing scheme on the graph and computes all the local $4$-profiles in parallel. We rely on two novel theoretical contributions: we show that local $4$-profiles can be calculated using compressed two-hop information and also establish novel concentration results that show that graphs can be substantially sparsified and still retain good approximation quality for the global $4$-profile. We empirically evaluate our algorithm using a distributed GraphLab implementation that we scaled up to $640$ cores. We show that our algorithm can compute global and local $4$-profiles of graphs with millions of edges in a few minutes, significantly improving upon the previous state of the art.Comment: To appear in part at WWW'1

A Compressed Sampling and Dictionary Learning Framework for WDM-Based Distributed Fiber Sensing

We propose a compressed sampling and dictionary learning framework for fiber-optic sensing using wavelength-tunable lasers. A redundant dictionary is generated from a model for the reflected sensor signal. Imperfect prior knowledge is considered in terms of uncertain local and global parameters. To estimate a sparse representation and the dictionary parameters, we present an alternating minimization algorithm that is equipped with a pre-processing routine to handle dictionary coherence. The support of the obtained sparse signal indicates the reflection delays, which can be used to measure impairments along the sensing fiber. The performance is evaluated by simulations and experimental data for a fiber sensor system with common core architecture.Comment: Accepted for publication in Journal of the Optical Society of America A [ \copyright\ 2017 Optical Society of America.]. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibite

Parallel Implementation of Efficient Search Schemes for the Inference of Cancer Progression Models

The emergence and development of cancer is a consequence of the accumulation over time of genomic mutations involving a specific set of genes, which provides the cancer clones with a functional selective advantage. In this work, we model the order of accumulation of such mutations during the progression, which eventually leads to the disease, by means of probabilistic graphic models, i.e., Bayesian Networks (BNs). We investigate how to perform the task of learning the structure of such BNs, according to experimental evidence, adopting a global optimization meta-heuristics. In particular, in this work we rely on Genetic Algorithms, and to strongly reduce the execution time of the inference -- which can also involve multiple repetitions to collect statistically significant assessments of the data -- we distribute the calculations using both multi-threading and a multi-node architecture. The results show that our approach is characterized by good accuracy and specificity; we also demonstrate its feasibility, thanks to a 84x reduction of the overall execution time with respect to a traditional sequential implementation