Defective neural motor speech mappings as a source for apraxia of speech : evidence from a quantitative neural model of speech processing

This unique resource reviews research evidence pertaining to best practice in the clinical assessment of established areas such as intelligibility and physiological functioning, as well as introducing recently developed topics such as conversational analysis, participation measures, and telehealth. In addition, new and established research methods from areas such as phonetics, kinematics, imaging, and neural modeling are reviewed in relation to their applicability and value for the study of disordered speech. Based on the broad coverage of topics and methods, the textbook represents a valuable resource for a wide ranging audience, including clinicians, researchers, as well as students with an interest in speech pathology and clinical phonetics

Lingual articulation in children with developmental speech disorders

This thesis presents thirteen research papers published between 1987-97, and a summary and discussion of their contribution to the field of developmental speech disorders. The publications collectively constitute a body of work with two overarching themes. The first is methodological: all the publications report articulatory data relating to tongue movements recorded using the instrumental technique of electropalatography (EPG). The second is the clinical orientation of the research: the EPG data are interpreted throughout for the purpose of informing the theory and practice of speech pathology. The majority of the publications are original, experimental studies of lingual articulation in children with developmental speech disorders. At the same time the publications cover a broad range of theoretical and clinical issues relating to lingual articulation including: articulation in normal speakers, the clinical applications of EPG, data analysis procedures, articulation in second language learners, and the effect of oral surgery on articulation. The contribution of the publications to the field of developmental speech disorders of unknown origin, also known as phonological impairment or functional articulation disorder, is summarised and discussed. In total, EPG data from fourteen children are reported. The collective results from the publications do not support the cognitive/linguistic explanation of developmental speech disorders. Instead, the EPG findings are marshalled to build the case that specific deficits in speech motor control can account for many of the diverse speech error characteristics identified by perceptual analysis in previous studies. Some of the children studied had speech motor deficits that were relatively discrete, involving, for example, an apparently isolated difficulty with tongue tiplblade groove formation for sibilant targets. Articulatory difficulties of the 'discrete' or specific type are consistent with traditional views of functional lingual articulation in developmental speech disorders articulation disorder. EPG studies of tongue control in normal adults provided insights into a different type of speech motor control deficit observed in the speech of many of the children studied. Unlike the children with discrete articulatory difficulties, others produced abnormal EPG patterns for a wide range of lingual targets. These abnormal gestures were characterised by broad, undifferentiated tongue-palate contact, accompanied by variable approach and release phases. These 'widespread', undifferentiated gestures are interpreted as constituting a previously undescribed form of speech motor deficit, resulting from a difficulty in controlling the tongue tip/blade system independently of the tongue body. Undifferentiated gestures were found to result in variable percepts depending on the target and the timing of the particular gesture, and may manifest as perceptually acceptable productions, phonological substitutions or phonetic distortions. It is suggested that discrete and widespread speech motor deficits reflect different stages along a developmental or severity continuum, rather than distinct subgroups with different underlying deficits. The children studied all manifested speech motor control deficits of varying degrees along this continuum. It is argued that it is the unique anatomical properties of the tongue, combined with the high level of spatial and temporal accuracy required for tongue tiplblade and tongue body co-ordination, that put lingual control specifically at risk in young children. The EPG findings question the validity of assumptions made about the presence/absence of speech motor control deficits, when such assumptions are based entirely on non-instrumental assessment procedures. A novel account of the sequence of acquisition of alveolar stop articulation in children with normal speech development is proposed, based on the EPG data from the children with developmental speech disorders. It is suggested that broad, undifferentiated gestures may occur in young normal children, and that adult-like lingual control develops gradually through the processes of differentiation and integration. Finally, the EPG fmdings are discussed in relation to two recent theoretical frameworks, that of psycho linguistic models and a dynamic systems approach to speech acquisition

Neural representations used by brain regions underlying speech production

Thesis (Ph.D.)--Boston UniversitySpeech utterances are phoneme sequences but may not always be represented as such in the brain. For instance, electropalatography evidence indicates that as speaking rate increases, gestures within syllables are manipulated separately but those within consonant clusters act as one motor unit. Moreover, speech error data suggest that a syllable's phonological content is, at some stage, represented separately from its syllabic frame structure. These observations indicate that speech is neurally represented in multiple forms. This dissertation describes three studies exploring representations of speech used in different brain regions to produce speech. The first study investigated the motor units used to learn novel speech sequences. Subjects learned to produce a set of sequences with illegal consonant clusters (e.g. GVAZF) faster and more accurately than a similar novel set. Subjects then produced novel sequences that retained varying phonemic subsequences of previously learned sequences. Novel sequences were performed as quickly and accurately as learned sequences if they contained no novel consonant clusters, regardless of other phonemic content, implicating consonant clusters as important speech motor representations. The second study investigated the neural correlates of speech motor sequence learning. Functional magnetic resonance imaging (fMRI) revealed increased activity during novel sequence productions in brain regions traditionally associated with non-speech motor sequence learning - including the basal ganglia and premotor cortex - as well as regions associated with learning and updating speech motor representations based on sensory input - including the bilateral frontal operculum and left posterior superior temporal sulcus (pSTs). Behavioral learning measures correlated with increased response for novel sequences in the frontal operculum and with white matter integrity under the pSTs, implicating functional and structural connectivity of these regions in learning success

Neural Modeling and Imaging of the Cortical Interactions Underlying Syllable Production

This paper describes a neural model of speech acquisition and production that accounts for a wide range of acoustic, kinematic, and neuroimaging data concerning the control of speech movements. The model is a neural network whose components correspond to regions of the cerebral cortex and cerebellum, including premotor, motor, auditory, and somatosensory cortical areas. Computer simulations of the model verify its ability to account for compensation to lip and jaw perturbations during speech. Specific anatomical locations of the model's components are estimated, and these estimates are used to simulate fMRI experiments of simple syllable production with and without jaw perturbations.National Institute on Deafness and Other Communication Disorders (R01 DC02852, RO1 DC01925

Learning and Production of Movement Sequences: Behavioral, Neurophysiological, and Modeling Perspectives

A growing wave of behavioral studies, using a wide variety of paradigms that were introduced or greatly refined in recent years, has generated a new wealth of parametric observations about serial order behavior. What was a mere trickle of neurophysiological studies has grown to a more steady stream of probes of neural sites and mechanisms underlying sequential behavior. Moreover, simulation models of serial behavior generation have begun to open a channel to link cellular dynamics with cognitive and behavioral dynamics. Here we summarize the major results from prominent sequence learning and performance tasks, namely immediate serial recall, typing, 2XN, discrete sequence production, and serial reaction time. These populate a continuum from higher to lower degrees of internal control of sequential organization. The main movement classes covered are speech and keypressing, both involving small amplitude movements that are very amenable to parametric study. A brief synopsis of classes of serial order models, vis-à-vis the detailing of major effects found in the behavioral data, leads to a focus on competitive queuing (CQ) models. Recently, the many behavioral predictive successes of CQ models have been joined by successful prediction of distinctively patterend electrophysiological recordings in prefrontal cortex, wherein parallel activation dynamics of multiple neural ensembles strikingly matches the parallel dynamics predicted by CQ theory. An extended CQ simulation model-the N-STREAMS neural network model-is then examined to highlight issues in ongoing attemptes to accomodate a broader range of behavioral and neurophysiological data within a CQ-consistent theory. Important contemporary issues such as the nature of working memory representations for sequential behavior, and the development and role of chunks in hierarchial control are prominent throughout.Defense Advanced Research Projects Agency/Office of Naval Research (N00014-95-1-0409); National Institute of Mental Health (R01 DC02852

Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter

Stuttering is a neurodevelopmental disorder that affects the smooth flow of speech production. Stuttering onset occurs during a dynamic period of development when children first start learning to formulate sentences. Although most children grow out of stuttering naturally, ∼1% of all children develop persistent stuttering that can lead to significant psychosocial consequences throughout one’s life. To date, few studies have examined neural bases of stuttering in children who stutter, and even fewer have examined the basis for natural recovery versus persistence of stuttering. Here we report the first study to conduct surface-based analysis of the brain morphometric measures in children who stutter. We used FreeSurfer to extract cortical size and shape measures from structural MRI scans collected from the initial year of a longitudinal study involving 70 children (36 stuttering, 34 controls) in the 3–10-year range. The stuttering group was further divided into two groups: persistent and recovered, based on their later longitudinal visits that allowed determination of their eventual clinical outcome. A region of interest analysis that focused on the left hemisphere speech network and a whole-brain exploratory analysis were conducted to examine group differences and group × age interaction effects. We found that the persistent group could be differentiated from the control and recovered groups by reduced cortical thickness in left motor and lateral premotor cortical regions. The recovered group showed an age-related decrease in local gyrification in the left medial premotor cortex (supplementary motor area and and pre-supplementary motor area). These results provide strong evidence of a primary deficit in the left hemisphere speech network, specifically involving lateral premotor cortex and primary motor cortex, in persistent developmental stuttering. Results further point to a possible compensatory mechanism involving left medial premotor cortex in those who recover from childhood stuttering.This study was supported by Award Numbers R01DC011277 (SC) and R01DC007683 (FG) from the National Institute on Deafness and other Communication Disorders (NIDCD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIDCD or the National Institutes of Health. (R01DC011277 - National Institute on Deafness and other Communication Disorders (NIDCD); R01DC007683 - National Institute on Deafness and other Communication Disorders (NIDCD))Accepted manuscrip

Experimental phonetic study of the timing of voicing in English obstruents

The treatment given to the timing of voicing in three areas of phonetic research -- phonetic taxonomy, speech production modelling, and speech synthesis -- Is considered in the light of an acoustic study of the timing of voicing in British English obstruents. In each case, it is found to be deficient. The underlying cause is the difficulty in applying a rigid segmental approach to an aspect of speech production characterised by important inter-articulator asynchronies, coupled to the limited quantitative data available concerning the systematic properties of the timing of voicing in languages. It is argued that the categories and labels used to describe the timing of voicing In obstruents are Inadequate for fulfilling the descriptive goals of phonetic theory. One possible alternative descriptive strategy is proposed, based on incorporating aspects of the parametric organisation of speech into the descriptive framework. Within the domain of speech production modelling, no satisfactory account has been given of fine-grained variability of the timing of voicing not capable of explanation in terms of general properties of motor programming and utterance execution. The experimental results support claims In the literature that the phonetic control of an utterance may be somewhat less abstract than has been suggestdd in some previous reports. A schematic outline is given, of one way in which the timing of voicing could be controlled in speech production. The success of a speech synthesis-by-rule system depends to a great extent on a comprehensive encoding of the systematic phonetic characteristics of the target language. Only limited success has been achieved in the past thirty years. A set of rules is proposed for generating more naturalistic patterns of voicing in obstruents, reflecting those observed in the experimental component of this study. Consideration Is given to strategies for evaluating the effect of fine-grained phonetic rules In speech synthesis

Coordination and timing of speech gestures in Parkinson’s disease

Many individuals with Parkinson's disease (PD) experience articulatory difficulties, which often have a considerable impact on their quality of life. It is currently poorly understood which mechanisms underlie these articulatory difficulties. In order to learn more about these mechanisms, this dissertation examined the coordination and timing of speech gestures in PD speech. Both these aspects are intrinsic to articulation, but at current it is unknown how they relate to the articulatory difficulties observed in PD speech. The studies in this dissertation address this issue using state-of-the-art methods. In the first study of this thesis, the effect of levodopa on vowel articulation in PD was examined. The results from this study suggest that articulation of vowels is not influenced by levodopa. In the following two studies, spatial and temporal aspects of speech gestures have been examined. The results from these studies suggest that the timing of speech gestures, and also the coupling between speech gestures is impaired in PD. In the final study of this dissertation, the prevalence and nature of tongue tremor in individuals with PD were investigated. Using a computer algorithm, we found different types of tongue tremor in our data, which we believe may affect the timing of speech gestures. Together, the studies in this dissertation show that coordination and timing are indeed impaired in the speech of (at least some) individuals with PD. We believe that this impairment may be caused by the presence of malfunctioning regulatory mechanisms in PD speech