3,695 research outputs found

    Observational energy transfers of a spiral cold filament within an anticyclonic eddy

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    The ocean surface mixed layer represents a critical interface linking the ocean and atmosphere. The physical processes determining the surface mixed layer properties and mediate atmosphere-ocean exchange. Submesoscale processes play a key role in cross-scale oceanic energy transformation and the determination of surface mixed-layer properties, including the enhancement of vertical nutrient transport, leading to increased primary productivity. Herein, we presented observations of the spiral chlorophyll-a filament and its influence on turbulence within an anticyclonic eddy in the western South China Sea during August 2021. The filament had a negative Ertel potential vorticity associated with strong upwelled/downward currents (approximately 20-40 m/day). Across-filament sections of the in-situ profiles showed turbulent dissipation rates enhanced in the filament. We suggested this enhancement values can be attributed to submesoscale processes, which accounted for 25% of the total parameterized turbulent dissipation rates. The present parametrized submesoscale turbulent scheme overestimated the in-situ values. The filament transferred kinetic energy upward to anticyclonic eddy via barotropic instability and gained energy from the anticyclonic eddy via baroclinic instability. After kinetic energy budget diagnostic, we suggested besides symmetric instability, centrifugal instability and mixed layer baroclinic instability should also be included in the turbulence scheme to overcome the overestimation. The observed dual energy transfers between the anticyclonic eddy and filament, and the observed high turbulent energy dissipation within the filament, emphasized the need for these processes to be accurately parameterized regional and climate models

    TFAW survey II: six newly validated planets and 13 planet candidates from K2

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    Searching for Earth-sized planets in data from Kepler's extended mission (K2) is a niche that still remains to be fully exploited. The TFAW survey is an ongoing project that aims to re-analyse all light curves in K2 C1-C8 and C12-C18 campaigns with a wavelet-based detrending and denoising method, and the period search algorithm TLS to search for new transit candidates not detected in previous works. We have analysed a first subset of 24 candidate planetary systems around relatively faint host stars (10.9 < Kp < 15.4) to allow for follow-up speckle imaging observations. Using vespa and TRICERATOPS, we statistically validate six candidates orbiting four unique host stars by obtaining false-positive probabilities smaller than 1 per cent with both methods. We also present 13 vetted planet candidates that might benefit from other, more precise follow-up observations. All of these planets are sub-Neptune-sized with two validated planets and three candidates with sub-Earth sizes, and have orbital periods between 0.81 and 23.98 d. Some interesting systems include two ultra-short-period planets, three multiplanetary systems, three sub-Neptunes that appear to be within the small planet Radius Gap, and two validated and one candidate sub-Earths (EPIC 210706310.01, K2-411 b, and K2-413 b) orbiting metal-poor stars

    Bright Opportunities for Atmospheric Characterization of Small Planets: Masses and Radii of K2-3 b, c, and d and GJ3470 b from Radial Velocity Measurements and Spitzer Transits

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    We report improved masses, radii, and densities for four planets in two bright M-dwarf systems, K2-3 and GJ3470, derived from a combination of new radial velocity and transit observations. Supplementing K2 photometry with follow-up Spitzer transit observations refined the transit ephemerides of K2-3 b, c, and d by over a factor of 10. We analyze ground-based photometry from the Evryscope and Fairborn Observatory to determine the characteristic stellar activity timescales for our Gaussian Process fit, including the stellar rotation period and activity region decay timescale. The stellar rotation signals for both stars are evident in the radial velocity data and is included in our fit using a Gaussian process trained on the photometry. We find the masses of K2-3 b, K2-3 c, and GJ3470 b to be 6.48{}-0.93+0.99, 2.14{}-1.04+1.08, and 12.58{}-1.28+1.31 M ⊕, respectively. K2-3 d was not significantly detected and has a 3σ upper limit of 2.80 M ⊕. These two systems are training cases for future TESS systems; due to the low planet densities (ρ < 3.7 g cm-3) and bright host stars (K < 9 mag), they are among the best candidates for transmission spectroscopy in order to characterize the atmospheric compositions of small planets

    TransitFit: combined multi-instrument exoplanet transit fitting for JWST, HST, and ground-based transmission spectroscopy studies

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    We present TRANSITFIT1, a package designed to fit exoplanetary transit light curves. TRANSITFIT offers multi-epoch, multi-wavelength fitting of multi-telescope transit data. TRANSITFIT allows per-telescope detrending to be performed simultaneously with transit parameter fitting, including custom detrending. Host limb darkening can be fitted using prior conditioning from stellar atmosphere models. We demonstrate TRANSITFIT in a number of contexts. We model multi-telescope broad-band optical data from the ground-based SPEARNET survey of the low-density hot-Neptune WASP-127b and compare results to a previously published higher spectral resolution GTC/OSIRIS transmission spectrum. Using TRANSITFIT, we fit 26 transit epochs by TESS to recover improved ephemeris of the hot-Jupiter WASP-91b and a transit depth determined to a precision of 111 ppm. We use TRANSITFIT to conduct an investigation into the contested presence of TTV signatures in WASP-126b using 180 transits observed by TESS, concluding that there is no statistically significant evidence for such signatures from observations spanning 27 TESS sectors. We fit HST observations of WASP-43 b, demonstrating how TRANSITFIT can use custom detrending algorithms to remove complex baseline systematics. Lastly, we present a transmission spectrum of the atmosphere of WASP-96b constructed from simultaneous fitting of JWST NIRISS Early Release Observations and archive HST WFC3 transit data. The transmission spectrum shows generally good correspondence between spectral features present in both data sets, despite very different detrending requirements

    Clinical Approach to Patients with Moderate-to-Severe Atopic Dermatitis: A Spanish Delphi Consensus

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    Despite emerging evidence and advances in the management of atopic dermatitis there a lack of consensus regarding the diagnostic criteria, therapeutic approach, method to assess severity, and patient follow-up for this condition. An expert consensus study was conducted to provide recommendations on the management of patients with moderate-to-severe atopic dermatitis. The study used Delphi-like methodology based on a literature review, a summary of the scientific evidence, and a 2-round survey. The agreement of 60 panellists on 21 statements was evaluated. Consensus was predefined as >= 80% agreement of all respondents. In the first round 6 statements reached consensus. Unanimous consensus was achieved regarding therapeutic goals and patient satisfaction (maintained in the long term and periodic goals reassessment recommended every 3-6 months). In the second round, half of the statements reached consensus, all related to patient follow-up, treatment goals, and atopic comorbidities. The statements that did not reach consensus were related to diagnosis (biomarkers, allergy, and food testing) and starting patients on conventional systemic treatment rather than advanced treatment. The study assessed expert opinion regarding a variety of topics related to the clinical approach to patients with moderate-to-severe atopic dermatitis, in order to provide guidance on the diagnosis and management of patients with atopic dermatitis

    Defining the immune phenotype of extremely early-onset type 1 diabetes

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    Type 1 diabetes is a lifelong autoimmune disease that is very rarely diagnosed in the first two years of life. We recently described a novel T1D phenotype, termed extremely early-onset T1D (here referred to as EXE-T1D) characterised by the development of T1D very early in life, which is associated with rapid and complete b-cell destruction. I therefore hypothesise that EXE-T1D may be the consequence of a more aggressive form of autoimmunity than seen in individuals who develop T1D at a later age. In this thesis this hypothesis was tested by comparing the immune phenotype of individuals with EXE-T1D and individuals with childhood or adulthood-onset T1D. Specifically, the frequency and phenotype of islet-specific T cells was assessed using sensitive FluoroSpot assays, and unbiased immune phenotyping was undertaken using five broad flow cytometry panels. Assessment of b-cell-specific T cell responses showed lower autoreactivity in the blood of EXE-T1D, and a decreased proportion of IL-10 responses close to diagnosis, suggestive of reduced immune regulation. Phenotypic characterisation of the circulating immune system identified increased frequencies of activated circulating follicular helper (aTfh) and peripheral helper (aTph) T cells co-expressing PD-1 and ICOS in EXE-T1D. Detailed examination of the phenotypic characteristics of these cells by single-cell transcriptional profiling revealed minor phenotypic differences between clinical cohorts, including a reduction in cell populations expressing heat shock proteins (HSP) and genes associated with an interferon (IFN) response. This study has revealed novel immune phenotypes associated with EXE-T1D which are currently being investigated as biomarkers of rapid b-cell destruction in larger cohorts of individuals with T1D. This work may therefore guide the selection of patients suitable for specific immune-based therapies to halt disease progression

    Evolutionary ecology of obligate fungal and microsporidian invertebrate pathogens

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    The interactions between hosts and their parasites and pathogens are omnipresent in the natural world. These symbioses are not only key players in ecosystem functioning, but also drive genetic diversity through co-evolutionary adaptations. Within the speciose invertebrates, a plethora of interactions with obligate fungal and microsporidian pathogens exist, however the known interactions is likely only a fraction of the true diversity. Obligate invertebrate fungal and microsporidian pathogen require a host to continue their life cycle, some of which have specialised in certain host species and require host death to transmit to new hosts. Due to their requirement to kill a host to spread to a new one, obligate fungal and microsporidian pathogens regulate invertebrate host populations. Pathogen specialisation to a single or very few hosts has led to some fungi evolving the ability to manipulate their host’s behaviour to maximise transmission. The entomopathogenic fungus, Entomophthora muscae, infects houseflies (Musca domestica) over a week-long proliferation cycle, resulting in flies climbing to elevated positions, gluing their mouthparts to the substrate surface, and raising their wings to allow for a clear exit from fungal conidia through the host abdomen. These sequential behaviours are all timed to occur within a few hours of sunset. The E. muscae mechanisms used in controlling the mind of the fly remain relatively unknown, and whether other fitness costs ensue from an infection are understudied.European Commissio

    TFAW survey - I. Wavelet-based denoising of K2 light curves. Discovery and validation of two new Earth-sized planets in K2 campaign 1

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    The wavelet-based detrending and denoising method TFAW is applied for the first time to EVEREST 2.0-corrected light curves to further improve the photometric precision of almost all K2 observing campaigns (C1-C8, C12-C18). The performance of both methods is evaluated in terms of 6 h combined differential photometric precision (CDPP), simulated transit detection efficiency, and planet characterization in different SNR regimes. On average, TFAW median 6 h CDPP is ∼30percent better than the one achieved by EVEREST 2.0 for all observing campaigns. Using the TRANSIT LEAST-SQUARES (TLS) algorithm, we show that the transit detection efficiency for simulated Earth-Sun-like systems is ∼8.5× higher for TFAW-corrected light curves than that for EVEREST 2.0 ones. Using the light curves of two confirmed exoplanets, K2-44 b (high SNR) and K2-298 b (low SNR), we show that TFAW yields better Markov chain Monte Carlo posterior distributions, transit parameters compatible with the catalogued ones but with smaller uncertainties, and narrows the credibility intervals. We use the combination of TFAW's improved photometric precision and TLS enhancement of the signal detection efficiency for weak signals to search for new transit candidates in K2 observing campaign 1. We report the discovery of two new K2-C1 Earth-sized planets statistically validated, using the VESPA software: EPIC 201170410.02, with a radius of 1.047+0.276−0.257R⊕ planet orbiting an M-type star, and EPIC 201757695.02, with a radius of 0.908+0.059−0.064R⊕ planet orbiting a K-type star. EPIC 201757695.02 is the 9th smallest planet ever discovered in K2-C1, and the 39th smallest in all K2 campaigns
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