4,014 research outputs found

    The medieval bronze doors of San Zeno, Verona: combining material analyses and art history

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    The bronze doors of the Basilica of San Zeno in Verona, Italy, are a special case in art history research. They were made by several workshops during the twelfth century: stylistically, two to three workshops were assumed to pro- duce the metal parts of the door. However, it is still unclear when exactly and if this interpretation can be supported by the chemical composition of the metal. In this research we aimed to verify the art history interpretation by iden- tifying the alloy composition of each individual metal plate. The composition of the supporting wooden structures are discussed. A portable ED-XRF instrument and optical microscopes were used to analyse and document the doors non-invasively. The doors were also photographed to produce high resolution orthophotos and 3D models. We can confirm that the metal parts of the doors were made of leaded tin-bronze as well as leaded brass and mounted on a wooden structure mainly made of spruce and oak wood. Chemically, two/three different groups of alloys have been identified, which can be associated with two or three different workshops, and which largely correspond to the stylistic interpretation

    Assessing the Role and Regulatory Impact of Digital Assets in Decentralizing Finance

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    This project will explore the development of decentralized financial (DeFi) markets since the first introduction of digital assets created through the application of a form of distributed ledger technology (DLT), known as blockchain, in 2008. More specifically, a qualitative inquiry of the role of digital assets in relation to traditional financial markets infrastructure will be conducted in order to answer the following questions: (i) can the digital asset and decentralized financial markets examined in this thesis co-exist with traditional assets and financial markets, and, if so, (ii) are traditional or novel forms of regulation (whether financial or otherwise) needed or desirable for the digital asset and decentralized financial markets examined herein? The aim of this project will be to challenge a preliminary hypothesis that traditional and decentralized finance can be compatible; provided, that governments and other centralized authorities approach market innovations as an opportunity to improve existing monetary infrastructure and delivery of financial services (both in the public and private sector), rather than as an existential threat. Thus, this thesis seeks to establish that, through collaborating with private markets to identify the public good to which DeFi markets contribute, the public sector can foster an appropriate environment which is both promotive and protective of the public interest without unduly stifling innovation and progress

    La traduzione specializzata all’opera per una piccola impresa in espansione: la mia esperienza di internazionalizzazione in cinese di Bioretics© S.r.l.

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    Global markets are currently immersed in two all-encompassing and unstoppable processes: internationalization and globalization. While the former pushes companies to look beyond the borders of their country of origin to forge relationships with foreign trading partners, the latter fosters the standardization in all countries, by reducing spatiotemporal distances and breaking down geographical, political, economic and socio-cultural barriers. In recent decades, another domain has appeared to propel these unifying drives: Artificial Intelligence, together with its high technologies aiming to implement human cognitive abilities in machinery. The “Language Toolkit – Le lingue straniere al servizio dell’internazionalizzazione dell’impresa” project, promoted by the Department of Interpreting and Translation (Forlì Campus) in collaboration with the Romagna Chamber of Commerce (Forlì-Cesena and Rimini), seeks to help Italian SMEs make their way into the global market. It is precisely within this project that this dissertation has been conceived. Indeed, its purpose is to present the translation and localization project from English into Chinese of a series of texts produced by Bioretics© S.r.l.: an investor deck, the company website and part of the installation and use manual of the Aliquis© framework software, its flagship product. This dissertation is structured as follows: Chapter 1 presents the project and the company in detail; Chapter 2 outlines the internationalization and globalization processes and the Artificial Intelligence market both in Italy and in China; Chapter 3 provides the theoretical foundations for every aspect related to Specialized Translation, including website localization; Chapter 4 describes the resources and tools used to perform the translations; Chapter 5 proposes an analysis of the source texts; Chapter 6 is a commentary on translation strategies and choices

    Influência da ausência do ponto de contato nos parâmetros periodontais: revisão sistemática

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    Introduction: There is no sufficient evidence of the contribution of proximal contact points on the integrity of periodontal tissue.. The aim of this paper was to evaluate the existing evidence on the absence of interproximal contact point and its influence on the development of periodontal alterations. Methods: Scielo, Web of Science, Scopus, PubMed - Medline, Cochrane, Lilacs databases and the grey literature accessed through Google Scholar and Open Grey were searched until January 2023 and 17034 articles were evaluated. Publications were assessed for eligibility using the Newcastle-Ottawa scale Results: One hundred thirty-eight articles were assessed for titles and abstracts and five cross-sectional observational studies met the criteria and were included for analysis. Four studies concluded that the absence of the contact point does not influence periodontal parameters and one study found that missing proximal contacts were associated with greater probing depth. However, only studies with moderate and low quality of evidence were found due to the high risk of bias.. Conclusions: Although the included studies indicate no influence of the absence of the interproximal contact point on periodontal parameters, the low level of quality of the studies weakens this finding.Introdução: Não se sabe ao certo se, Pontos de contatos proximais podem contribuir para a integridade dos tecidos periodontais. O objetivo deste trabalho foi avaliar a evidência existente sobre ausência de ponto de contato interproximal e sua influência no desenvolvimento dealterações periodontais. Métodos: As bases de dados Scielo, Web of Science, Scopus, PubMed – Medline, Cochrane, Lilacs e a literatura cinzenta acessada pelo Google Scholar e Open Grey foram pesquisadas até janeiro de 2023 e 17034 artigos foram avaliados. As publicações foram avaliadas quanto à elegibilidade, utilizando a escala Newcastle-Ottawa. Resultados: Cento e trinta e oito artigos foram avaliados títulos e resumos e cinco estudos observacionais transversais atenderam aos critérios e foram incluídos para análise. Quatro estudos concluíram que a ausência do ponto de contato não influencia nos parâmetros periodontais e um estudo encontrou que contatos proximais ausentes foram associados a maior profundidade de sondagem. No entanto, foram encontrados apenas estudos com qualidade de evidência moderados e baixos devido ao alto risco de viés. Conclusões: Apesar de os estudos incluídos indicarem não haver influência da ausência do ponto de contato interproximal nos parâmetros periodontais, o baixo nível na qualidade dos estudos enfraquece este achado

    Avaliação da conformidade das informações relacionadas às comorbidades de pacientes com COVID-19 notificados no sistema de vigilância SIVEP-GRIPE em relação aos registros assistenciais de um hospital universitário

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    Introdução: a partir do reconhecimento da transmissão comunitária do vírus Sars- CoV-2 no território brasileiro em 20 de março de 2020, foi realizada adaptação do Sistema de Vigilância de Síndromes Respiratórias Agudas (SRAG), Sivep – Gripe, para monitoramento da circulação simultânea do coronavírus Sars-CoV-2, Influenza e outros vírus respiratórios. Objetivo: qualificar a análise das comorbidades e suas relações com desfecho óbito na COVID-19. Método: avaliada a completude e concordância das comorbidades (através do coeficiente de kappa), a partir do relacionamento determinístico das bases do SIVEP-GRIPE e do banco assistencial HCPA. Realizada análise multivariável, obtendo-se razão de chances (RC) de cada comorbidade frente ao desfecho óbito. O período analisado foi de março de 2020 a dezembro de 2021. Resultados: a amostra foi constituída por 2864 pares verdadeiros. As comorbidades com maior percentual de preenchimento no banco assistencial do HCPA foram: hipertensão arterial sistêmica (58,4%), diabetes mellitus (33,8%) e obesidade (30,9%). Já no SIVEP-GRIPE foram as seguintes: doença cardiovascular crônica (55,6%), diabetes mellitus (31,2%) e obesidade (16,9%). CAs comorbidades comRC com significância estatística frente o desfecho óbito foram: doença hematológica RC 2,06 (IC 95%:1,14 - 3,75) e idade RC 1,05 (IC 95%:1,05 - 1,06), pneumopatia à exceção de asma RC 1,90 (IC 95%:1,50 - 2,42), doença renal crônica RC 1,83 (IC 95%:1,44 - 3,75), hepática RC 1,59 (IC 95%:1,07-2,37), neoplasia RC 1,47 (IC 95%:1,02- 2,13), doença cardiovascular RC 1,28 (IC 95%:1,02-1,62). Conclusão: aextração de dados assistenciais para geração de banco de dados e consequente linkage com sistema de notificação oficial do Ministério da Saúde mostrou ser importante ferramenta para informações mais acuradas e oportunas. O estudo sugere inserção de variável estruturada em relação à transferências e a comorbidade neoplasia no SIVEP-GRIPE.Introduction: based on the recognition of community transmission of the Sars-CoV-2 virus in Brazil on March 20, 2020, the Acute Respiratory Syndrome Surveillance System (SARS), Sivep – Gripe, was adapted to monitor simultaneous circulation of the coronavirus Sars-CoV-2, Influenza and other respiratory viruses. Objective: we sought to qualify the analysis of filling out comorbidities and their relationships with the outcome of death in COVID-19. Method: the completeness and concordance of comorbidities were assessed (kappa coefficient) based on the deterministic relationship between the SIVEP-GRIPE bases and the Hcpa assistance bank. Multivariate analysis was performed, obtaining the odds ratio (OR) of each comorbidity against the death outcome. The analyzed period was from March 2020 to December 2021. Results: the sample consisted of 2864 true pairs. The comorbidities with the highest percentage of completion in the Hcpa care bank were: systemic arterial hypertension (58.4%), diabetes mellitus (33.8%) and obesity (30.9%). In SIVEP- GRIPE, they were as follows: chronic cardiovascular disease (55.6%), diabetes mellitus (31.2%) and obesity (16.9%). The comorbidities with OR with statistical significance in view of the death outcome were: hematological disease OR 2,06 (CI 95%:1,14-3,75), age OR 1,05 (CI 95%: 1,05-1,06), lung disease with the exception of asthma OR 1,90 (CI 95%:1,50-2,42), chronic kidney disease OR 1,83 (CI 95%:1,44-3,75), liver disease OR 1,59 (CI 95%: 1,07- 2,37), neoplasia OR 1,47 (CI 95%: 1,03-2,13), chronic cardiovascular disease OR 1,28 (CI 95%: 1,02-1,62). Conclusion: The extraction of assistance data to generate a database and consequent linkage with the official notification system of the Ministry of Health proved to be an important tool for more accurate and timely information. The study suggests insertion of a structured variable in relation to transfers and malignant neoplasm comorbidity in SIVEP-GRIPE

    Annual Report 2022

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    Contribuições ao estudo da epidemiologia e diagnóstico da esporotricose humana de transmissão felina : casuística 2011-2022 no CHC-UFPR e avaliação de teste rápido para imunodiagnóstico

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    Orientador: Prof. Dr. Flávio de Queiroz Telles FilhoCoorientadora: Profa. Dra. Izabella Castilhos Ribeiro dos Santos WeissTese (doutorado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Defesa : Curitiba, 11/05/2023Inclui referênciasResumo: Esporotricose é a micose de implantação mais prevalente no mundo. A Esporotricose de Transmissão Felina (ETF) causada por Sporothrix brasiliensis emergiu como uma importante zoonose no Brasil e países limítrofes. Descrevemos a evolução da ETF, calculamos a incidência da doença, mapeamos a distribuição geográfica dos casos observados em Curitiba, Paraná, Brasil. Além disso, avaliamos o desempenho de um teste por imunocromatografia de fluxo lateral (do inglês: Lateral Flow Assay, LFA) para a detecção de anticorpos anti-Sporothrix em soro humano. Para o estudo epidemiológico, foram revisados 216 prontuários médicos de pacientes com esporotricose atendidos no Hospital de Clínicas, Universidade Federal do Paraná (HC-UFPR), Curitiba, Brasil, de 2011 a 2022. Para avaliação do teste para detecção de anticorpos (Anti-Sporo LFA) em soro humano, desenvolvido pela IMMY, foram analisadas 300 amostras de soro humano coletadas prospectivamente no HC-UFPR. A taxa de incidência de ETF aumentou de 0,3 casos por 100.000 pacientes ambulatoriais em 2011, para 21,4 em 2021, com a maior parte dos casos (58%; n=126) diagnosticados no período de 2019-2021. Anti-Sporo LFA mostrou sensibilidade global de 83% (intervalo de confiança [IC] 95% = 74%-90%) e especificidade global de 82% (IC 95% = 77%-86%). Desde o primeiro relato de ETF em Curitiba em 2011, a esporotricose teve um aumento significante. Tendências no aumento da incidência indicam a transmissão contínua da doença. Ações no controle da transmissão são necessárias. O estudo é o primeiro a avaliar teste imunodiagnóstico por imunocromatografia de fluxo lateral para detecção de anticorpos anti-Sporothrix em soro humano. Os achados mostram que o IMMY's Anti-Sporo LFA é uma ferramenta promissora para o diagnóstico rápido da ETF.Abstract: Sporotrichosis is the most prevalent implantation mycoses in the world. Cattransmitted sporotrichosis (CTS) caused by Sporothrix brasiliensis has emerged as an important zoonosis in Brazil and neighbouring countries. We described the evolution of CTS, calculated disease incidence, and mapped the geographic distribution of cases seen in a Curitiba, Brazil. Furthermore, we evaluate the performance of a lateral flow assay (LFA) for the detection of anti-Sporothrix antibodies in human sera. For the epidemiological study we reviewed medical records of 216 sporotrichosis cases attended at the Hospital de Clínicas, Federal University of Paraná (HC-UFPR), Curitiba, Brazil, from 2011 to 2022. The LFA for the detection of anti-Sporothrix antibodies (Anti-Sporo LFA) in human sera, developed by IMMY, was evaluated using 300 human sera collected prospectively at HC-UFPR. The incidence rate of CTS increased from 0.3 cases per 100,000 outpatient visit-years (OPVY) in 2011, to 21.4 cases per 100,000 OPVY in 2021, with most cases (58%, n=126) diagnosed during 2019-2021. The Anti-Sporo LFA showed a global sensitivity of 83% (95% confidence interval [CI] = 74%-90%), a global specificity of 82% (95% CI = 76%-87%), and accuracy of 82% (95% CI = 77%-86%). Since the first report of CTS in Curitiba in 2011, sporotrichosis has been increase significantly. Trends on incidence increasing indicate the continuous transmission of the disease. Actions to control transmission are needed. This study presents the results of the evaluation of the first lateral flow assay for the detection of anti-Sporothrix antibodies in human sera. The findings here show evidence that IMMY's Anti-Sporo LFA is a promising tool for the rapid diagnosis of CTS

    Structuring perception : how structures of practice influence decision-making at the Court of Justice of the European Union

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    Defence date: 29 September 2023Examining board: Prof. Dr. Urška Šadl (European University Institute, supervisor); Prof. Dr. Dr. hc. Hans-Wolfgang Micklitz (Robert Schuman Centre for Advanced Studies, European University Institute); Prof. Dr. Fernanda G. Nicola (American University Washington College of Law); Ass. Prof. Dr. Salvatore Caserta (Københavns Universitet)This thesis studies the impact of working processes and working culture at the Court of Justice of the European Union on the stabilisation and destabilisation of its decision-making. The theoretical framework is a Bourdieu’s theory of practice. I argue that the simultaneous relative indeterminism and determinism of decision-making, i. e. the fact that it produces relatively consistent outcomes and despite lawyers’ persistent disagreement, can best be explained by seeing it as a struggle among judges who try to enshrine their own perception of the case. However, I consider this struggle as more than a game of politics. The Judges perceptions are based on deeply inculcated schemata of perception. On the national level, these are primarily created by shared legal education and professional socialisation. But Judges at the Court of Justice come from diverse sets of legal systems and professional backgrounds. Hence, the structural factors of the practice at the Court have to carry much of the burden. I identify ten specific factors, such as the assignment of Judge-Rapporteurs, the chamber system, the single voice approach or the Court’s approach to case-law. In two case-studies on gender equality and childcare-related leave cases, I study the impact of these factors. In this area, the Court’s caselaw has often been criticised as incoherent, which allows me to identify competing perceptions. I then examine which structural factors can help to understand periods of increase convergence around a dominant schema, and which are related to periods of more contest and divergence. I find that the impact of the factors varies depending on their mutual interaction with other factors and that, for example, the often-studied Judge-Rapporteur alone cannot explain periods of convergence. The thesis thus furthers our understanding of the judicial process at the Court of Justice by revealing the comprehensive interrelationships between these factors

    Efeitos agudos do consumo de bebidas energéticas nos parâmetros cardiovasculares em adultos saudáveis: uma revisão sistemática com metanálise de ensaios clínicos randomizados

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    The market for energy drinks (EDs) has grown exponentially among the young adult population in recent years due to their ability to improve feelings of fatigue, concentration and physical performance. This is due to the high caffeine content in their composition. Anecdotal evidence suggests that BE consumption may cause acute changes in cardiovascular parameters, but there is no agreement on the true magnitude of these effects. The objective of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to evaluate the acute and subacute effects of different durations of EDs consumption on systolic (SBP) and diastolic (DBP) blood pressure, resting heart rate (HRrp), cardiac output (CO), endothelial function, QT interval (QT), and corrected QT interval (QTc) in healthy adults. A protocol article was previously developed. Searches included PubMed, EMBASE, Cochrane, LILACS, Web of Science and SportDiscus databases and grey literature. Results are presented as mean difference between the intervention group (EDs) and the control condition (BC) and 95% confidence interval (95% CI). To estimate effects in future studies, 95% prediction interval (95% PI; ≥ 3 studies) was included. Heterogeneity was assessed by the Higgins' test (I²). Outliers were assessed by the lack of overlap of the 95% CIs. Analyses were performed in RStudio using the "meta" package. Seventeen studies (n= 475) were included, of which 14 were crossover RCTs. SBP and DBP data were evaluated in 16 studies, HR in 15, CO in three, QT and QTc in five. After BE consumption, SBP increased 3.23 mmHg (95% CI 1.19 to 5.28, p < 0.01) after 30 to 40 minutes, 4.61 mmHg (95% CI 2.80 to 6.42, p < 0.01) after 60 to 80 minutes, 4.10 mmHg (95% CI 1.63 to 6.56, p < 0.01) after 90 to 100 minutes, and 3.64 mmHg (95% CI 1.66 to 5.63, p < 0.01) after 120 minutes. DBP increased 2.92 mmHg (95% CI 0.91 to 4.94, p < 0.01) before 20 minutes, 2.22 mmHg (95% CI 0.84 to 3.59, p < 0.01) between 30 and 40 minutes, 2.73 mmHg (95% CI 1.46 to 4, 01, p < 0.01) between 60 and 80 minutes, 3.77 mmHg (95% CI 2.02 to 5.52, p < 0.01) between 90 and 100 minutes, and 4.58 mmHg (95% CI 2.73 to 6.43, p < 0.01) after 120 minutes. The CO increased by 0.43 L/min (95% CI 0.08 to 0.77, p= 0.016) only in the 30 to 40 minutes period after the intervention. HRrep, QT and QTc showed no significant changes. No studies were found that evaluated endothelial function. In conclusion, acute consumption of BEs increases SBP and DBP for up to two hours after ingestion. Furthermore, there was little change in CO and no effect on HR and QT/QTc in healthy adults. However, due to the small number of studies involved, the results should be interpreted with caution.O mercado de bebidas energéticas (BEs) tem crescido exponencialmente nos últimos anos entre a população jovem-adulta devido a sua capacidade de melhorar a sensação de fadiga, concentração e desempenho físico. Isso se deve ao alto teor de cafeína em sua composição. Evidências isoladas sugerem que o consumo de BE pode causar alterações agudas nos parâmetros cardiovasculares, mas não há concordância sobre a verdadeira magnitude desses efeitos. O objetivo desta revisão sistemática com metanálise de ensaios clínicos randomizados (ECRs) foi avaliar os efeitos agudos e subagudos do consumo de BEs em diferentes períodos de tempo na pressão arterial sistólica (PAS) e diastólica (PAD), frequência cardíaca de repouso (FCrep), débito cardíaco (DC), função endotelial, intervalo QT (QT) e QT corrigido (QTc) em adultos saudáveis. Um artigo protocolo foi previamente elaborado. As buscas incluíram as bases PubMed, EMBASE, Cochrane, LILACS, Web of Science e SportDiscus e a literatura cinzenta. Os resultados estão apresentados em diferença de médias entre o grupo intervenção (BE) comparado a condição controle (BC) e intervalo de confiança de 95% (IC 95%). Para estimar efeitos em estudos futuros foi incluído intervalo de predição de 95% (IP 95%; ≥ 3 estudos). A heterogeneidade foi avaliada pelo teste de Higgins (I²). Outliers foram avaliados pela falta de sobreposição dos IC 95%. As análises foram realizadas no RStudio no pacote “meta”. Foram incluídos 17 estudos (n= 475), desses, 14 eram ECRs cruzado. Os dados de PAS e PAD foram avaliados em 16 estudos, a FC em 15, o DC em três, o QT e o QTc em cinco. Após o consumo da BE, a PAS aumentou 3,23 mmHg (IC 95% 1,19 a 5,28, p < 0,01) após 30 a 40 minutos, 4,61 mmHg (IC 95% 2,80 a 6,42, p < 0,01) após 60 a 80 minutos, 4,10 mmHg (IC 95% 1,63 a 6,56, p < 0,01) após 90 a 100 minutos e 3,64 mmHg (IC 95% 1,66 a 5,63, p < 0,01) após 120 minutos. A PAD aumentou 2,92 mmHg (IC 95% 0,91 a 4,94, p < 0,01) antes de 20 minutos, 2,22 mmHg (IC 95% 0,84 a 3,59, p < 0,01) entre 30 e 40 minutos, 2,73 mmHg (IC 95% 1,46 a 4,01, p < 0,01) entre 60 e 80 minutos, 3,77 mmHg (IC 95% 2,02 a 5,52, p < 0,01) entre 90 e 100 minutos e 4,58 mmHg (IC 95% 2,73 a 6,43, p < 0,01) após 120 minutos. O DC aumentou 0,43 L/min (IC 95% 0,08 a 0,77, p= 0,016) somente no período de 30 a 40 minutos após a intervenção. A FCrep, o QT e o QTc não apresentaram alterações significativas. Não foram encontrados estudos que avaliaram a função endotelial. Em conclusão, o consumo agudo de BEs aumenta a PAS e PAD por até duas horas após sua ingestão. Além disso, houve pequena modificação no DC e nenhuma influência na FC e no QT/QTc em adultos saudáveis. No entanto, pelo reduzido número de estudos envolvidos, os resultados devem ser interpretados com cautela.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superio
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