Application of the ESR spectroscopy to estimate the original dose in irradiated chicken bone

The paper discusses the results of an investigation aimed to use the ESR spectroscopy as a quantitative procedure to estimate the original dose in irradiated chicken. The time stability of the ESR signal was at first carried out, to obtain a correction factor to be applied to the dose estimated with the added dose method. Our results show that this procedure gives an estimation of the original dose within ±25%

A Statement of Moral Purpose: The 1948 Genocide Convention

Genocide was declared an international crime in 1946. In response to this declaration, the Convention on Prevention and Punishment of the Crime of Genocide was adopted in 1948. Although 28 years have passed, the United States has not yet determined its position, with respect to the Convention and this international compact is still pending before the Senate. This article is concerned primarily with the probable impact of the United States\u27 position on the Genocide Convention in light of international law and relations. The body of the Convention is discussed and analyzed along with three proposed United States\u27 understandings. It is argued that, as the United States is now reestablishing its moral leadership in the world, ratification of the Genocide Convention is in our national interest as a statement of faith in our national principles and of the readiness to develop international law on human rights

High-field plasma acceleration in a high-ionization-potential gas

International audiencePlasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ionized by the head of the drive beam, in which case the distance of acceleration and energy gain can be strongly limited by head erosion. Here we overcome this limit and demonstrate that electrons in the tail of a drive beam can be accelerated by up to 27 GeV in a high-ionization-potential gas (argon), boosting their initial 20.35 GeV energy by 130%. Particle-in-cell simulations show that the argon plasma is sustaining very high electric fields, of ~150 GV/m, over ~20 cm. The results open new possibilities for the design of particle beam drivers and plasma sources

International Water Law for The 21st Century: The Contribution Of the U.N. Convention

In May, 1997, the United Nations General Assemblyadopted the Convention on the Law of the Non-Navigational Uses of International Watercourses, a treatythat largely codifies the general principles ofinternational water law. While not entirely free fromcontroversy, the Convention has already been influentialand will doubtless continue to be well into the 21stcentury. This paper provides an overview of theConvention, comments on some of its salient provisions,and considers its future influence

Pre-eruptive magmatic processes re-timed using a non-isothermal approach to magma chamber dynamics

Open Source PaperThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The attached file is the published version of the article

Sixfold improved single particle measurement of the magnetic moment of the antiproton

Our current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value /2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.792847350(9), and therefore agrees with the fundamental charge, parity, time (CPT) invariance of the Standard Model of particle physics. Additionally, our result improves coefficients of the standard model extension which discusses the sensitivity of experiments with respect to CPT violation by up to a factor of 20.EU/ERC/290870-MEFUCOMax-Planck SocietyHelmholtz-GemeinschaftRIKEN Initiative Research Unit ProgramRIKEN President FundingRIKEN Pioneering Project FundingRIKEN FPR FundingRIKEN JRA ProgramMEXT/24000008Max-Planck SocietyEU/ERC Advanced Grant/290870-MEFUCOHelmholtz-GemeinschaftCERN-fellowship program

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

This work was funded by grants to C.L. from the National Natural Science Foundation of China (81373283 and U1402222). J.H.N. is supported as an award holder of Chinese National Thousand Talents Program, Wellcome Trust Senior Investigator Award (WT100209MA) and Royal Society Wolfson Merit Award. X.Z. is supported by Sichuan Province Thousand Talents Scheme in China and the State Key Program of National Natural Science of China (21534008).Molecules which alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin and structural biology has explained the basis of their action and permitted design of new drugs. However by shifting the profile of β-tubulin isoforms, cancer cells become resistant to treatment. Compounds that bind to α-tubulin are less well characterized and unexploited. The natural product pironetin is known to bind to α-tubulin and is a potent inhibitor of microtubule polymerization. Previous reports had identified that pironetin reacts with lysine-352 residue however analogues designed on this model had much lower potency which was difficult to explain, hindering further development. We report crystallographic and mass spectrometric data that reveal that pironetin forms a covalent bond to cysteine-316 in α-tubulin via a Michael addition reaction. These data provide a basis for the rational design of α-tubulin targeting chemotherapeutics.Publisher PDFPeer reviewe

Ecological and genetic basis of metapopulation persistence of the Glanville fritillary butterfly in fragmented landscapes

Ecologists are challenged to construct models of the biological consequences of habitat loss and fragmentation. Here, we use a metapopulation model to predict the distribution of the Glanville fritillary butterfly during 22 years across a large heterogeneous landscape with 4,415 small dry meadows. The majority (74%) of the 125 networks into which the meadows were clustered are below the extinction threshold for long-term persistence. Among the 33 networks above the threshold, spatial configuration and habitat quality rather than the pooled habitat area predict metapopulation size and persistence, but additionally allelic variation in a SNP in the gene Phosphoglucose isomerase (Pgi) explains 30% of variation in metapopulation size. The Pgi genotypes are associated with dispersal rate and hence with colonizations and extinctions. Associations between Pgi genotypes, population turnover and metapopulation size reflect eco-evolutionary dynamics, which may be a common feature in species inhabiting patch networks with unstable local dynamics.Peer reviewe

Pop-Culture Politics: How Cable News Created the Tea Party, Trump, and a Fake Populist Movement

The populist tradition in the United States originated in the nineteenth century with the Populist Party. Since, political movements in the United States and across the globe have been declared populist for their anti-elite, nostalgic message. Most recently, the Donald Trump campaign for president was declared populist because of a perceived economic message that contradicted traditional conservative ideology. However, Trump\u27s movement was not the grassroots sort that he presented it to be. Rather, his was an extension of a particular, socially and culturally motivated faction of the Tea Party. This faction was radicalized in the first decade of the 21st century by right-wing news outlets like Fox News. Polling data suggests both the Tea Party and Trump movement were not economically motivated—as populists are—but socially and culturally motivated instead. Further, their positions are ones that were push by Fox News in the decade prior to the rise of the Tea Party. Therefore, the Trump movement is not populist, but cable conservative instead