One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

BACKGROUND Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. METHODS We recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD2 score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke over a period of 1 year. RESULTS From 2009 through 2011, we enrolled 4789 patients at 61 sites in 21 countries. A total of 78.4% of the patients were evaluated by stroke specialists within 24 hours after symptom onset. A total of 33.4% of the patients had an acute brain infarction, 23.2% had at least one extracranial or intracranial stenosis of 50% or more, and 10.4% had atrial fibrillation. The Kaplan–Meier estimate of the 1-year event rate of the composite cardiovascular outcome was 6.2% (95% confidence interval, 5.5 to 7.0). Kaplan–Meier estimates of the stroke rate at days 2, 7, 30, 90, and 365 were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%, respectively. In multivariable analyses, multiple infarctions on brain imaging, large-artery atherosclerosis, and an ABCD2 score of 6 or 7 were each associated with more than a doubling of the risk of stroke. CONCLUSIONS We observed a lower risk of cardiovascular events after TIA than previously reported. The ABCD2 score, findings on brain imaging, and status with respect to large-artery atherosclerosis helped stratify the risk of recurrent stroke within 1 year after a TIA or minor stroke. (Funded by Sanofi and Bristol-Myers Squibb.)Supported by an unrestricted grant from Sanofi and Bristol-Myers Squibb

Paraoxonase gene polymorphisms and haplotype analysis in a stroke population

Peer reviewedPublisher PD

The biochemical, physiological, and metabolic evaluation of human subjects wearing pressure suits and on a diet of precooked freeze dehydrated foods

Biochemical, physiological and metabolic evaluation of human subjects wearing pressure suits and on diet of precooked frozen dehydrated food

Increased Risk of Ischemic Stroke during Sleep in Apneic Patients.

BACKGROUND AND PURPOSE:The literature indicates that obstructive sleep apnea (OSA) increases the risk of ischemic stroke. However, the causal relationship between OSA and ischemic stroke is not well established. This study examined whether preexisting OSA symptoms affect the onset of acute ischemic stroke. METHODS:We investigated consecutive patients who were admitted with acute ischemic stroke, using a standardized protocol including the Berlin Questionnaire on symptoms of OSA prior to stroke. The collected stroke data included the time of the stroke onset, risk factors, and etiologic subtypes. The association between preceding OSA symptoms and wake-up stroke (WUS) was assessed using multivariate logistic regression analysis. RESULTS:We identified 260 subjects with acute ischemic strokes with a definite onset time, of which 25.8% were WUS. The presence of preexisting witnessed or self-recognized sleep apnea was the only risk factor for WUS (adjusted odds ratio=2.055, 95% confidence interval=1.035-4.083, p=0.040). CONCLUSIONS:Preexisting symptoms suggestive of OSA were associated with the occurrence of WUS. This suggests that OSA contributes to ischemic stroke not only as a predisposing risk factor but also as a triggering factor. Treating OSA might therefore be beneficial in preventing stroke, particularly that occurring during sleep

The Biochemical, Physiological, and Metabolic Evaluation of Human Subjects in a Life Support Systems Evaluator and on a Diet of Precooked Freeze Dehydrated Foods Final Report, 12 Oct. - 24 Nov. 1964

Human water, caloric, and protein requirements in simulated life support system with dietary restrictio

Biochemical and physiological evaluation of human subjects in a life support systems evaluator

Biochemical and physiological evaluation of human nutritional requirements under simulated aerospace condition

Named Entity Recognition in Twitter using Images and Text

Named Entity Recognition (NER) is an important subtask of information extraction that seeks to locate and recognise named entities. Despite recent achievements, we still face limitations with correctly detecting and classifying entities, prominently in short and noisy text, such as Twitter. An important negative aspect in most of NER approaches is the high dependency on hand-crafted features and domain-specific knowledge, necessary to achieve state-of-the-art results. Thus, devising models to deal with such linguistically complex contexts is still challenging. In this paper, we propose a novel multi-level architecture that does not rely on any specific linguistic resource or encoded rule. Unlike traditional approaches, we use features extracted from images and text to classify named entities. Experimental tests against state-of-the-art NER for Twitter on the Ritter dataset present competitive results (0.59 F-measure), indicating that this approach may lead towards better NER models.Comment: The 3rd International Workshop on Natural Language Processing for Informal Text (NLPIT 2017), 8 page

Ballpark boom : new minor league stadiums spring up across the region

Related links : http://www.richmondfed.org/publications/research/region_focus/2009/winter/feature3_weblinks.cfmSports teams