Endemic goitre: with special reference to its occurrence in the Loch Tay district of Perthshire

Section I. INTRODUCTION. Definition. Synonyms. Introductory remarks. Notes on the Climate, Topography, etc., etc., of the Loch Tay area of Perthshire. • Section II. HISTORICAL OUTLINE References by Greek and Roman writers. Endemic Goitre in the Middle Ages. Modern Investigators, etc. • Section III. DISTRIBUTION. Geographical Distribution - Europe, Asia, etc - die - tribution in Britain. Physiographical Distribution. Influence of factors - elevations, latitude, urban or rural, etc. Geological Distribution. • Section IV. A. ETIOLOGY. Influence of certain factors: -- Position in animal Kingdom; race; age; heredity; sex; etc. • Section IV. B. ETIOLOGY - ESSENTIAL CAUSE. Introduction. Water as the usual vehicle. Non-organic theories of Causation. Organic theories of causation. Epidemic goitre, etc. • Section V. PATHOLOGY. Pathology of the Thyroid Tumour. Haematological changes. Changes in the Iodine Content of the Gland. Probable pathogenesis of the condition. • Section VI. COURSE AND SYMPTOMS. • Section VII. OBJECTIVE SIGNS, DIAGNOSIS, PROGNOSIS. Clinical appearance and palpation of the thyroid enlargement. Differential diagnosis. Prognosis. • Section VIII. TREATMENT. Palliative treatment. Curative and Palliative treatment. • Section IX. ADDITIONAL REMARK, ETC. SUMMARY AND CONCLUSIONS. • Section X. RECORDED CASES. • Section XI. APPENDIX. • Section XII BIBLIOGRAPHY • MAPS. I. Goitre Map of the World. II. Goitre Map of Scotland. III. Goitre Map of Perthshire (Distribution in School Children) IV. Goitre Map of the Loch Tay Endemic Area. V.& VI. Geological Map and Section of the Loch Tay Endemic Area