28 research outputs found

    The effects of the adrenal cortex on Electrolyte and water metabolism

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    Thesis (M.A.)--Boston Universit

    Calcium Oxalate Urolithiasis in the Rat: Is it a Model for Human Stone Disease? A Review of Recent Literature

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    Calcium oxalate stone disease is the most common human urinary stone disease in the Western Hemisphere. To understand different aspects of the disease, calcium oxalate urolithiasis in the rat is used as a model. Spontaneous calcium oxalate urolithiasis is very rare in rats. Thus the disease is experimentally induced and the rats are generally made hyperoxaluric either by administration of excess oxalate, exposure to the toxin ethylene glycol, or various nutritional manipulations. All the experimental models show renal injury associated with crystal deposition. Calcium oxalate crystals are in most cases intraluminal in renal tubules and often attached to the basal lamina of the denuded epithelium. Rat renal papillary tips and fornices appear to be the preferential sites for the deposition of large calcium oxalate calculi. Where urinary supersaturation of calcium oxalate has been studied the crystal forming rat urines are shown to have higher urinary supersaturation of calcium oxalate than their controls. Oxalate metabolism in the rat is nearly identical to that in humans. Thus, in a number of respects, experimental calcium oxalate urolithiasis in the rat is similar to calcium oxalate stone disease in man

    Non-specific protein therapy

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    #1. Twenty cases of erysipelas have been treated with milk injections, and a comparison made between these and twenty similar cases treated by other methods. #2. Milk injections have their greatest value in recurrent cases and in erysipelas 'migrans'. #3. Twenty cases of asthma were treated by injections of old tuberculin. #4. This treatment is safe and successful in cases of asthma which have failed to respond to other methods of treatment. #5. Twenty cases of rheumatoid arthritis were treated by injections of typhoid -paratyphoid vaccine #6. This treatment must be used with care and judg- ment because it is apt to be followed by severe reactions. #7. Injection of vaccine should not be used as a routine measure in rheumatoid arthritis, but may be tried when other well -recognised forms of treatment have failed. #8. The treatment is most valuable in cases which show synovial changes rather than in those which showed marked bony change. #9 . Twenty cases of general paralysis of the insane Acre treated by malarial therapy. #10. 45% of the cases were observed to have benefited by this treatment for a period of at least twelve months after injection. #11. One case died as a direct result of malarial treatment. Patients must be carefully selected for this treatment. #12. Improvement in the blood and cerebro- spinal fluid is sometimes observed after treatment. #13. Best results were obtained when anti - syphilitic treatment was given before and after malaria

    Public Health Rep

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