A digital platform for the design of patient-centric supply chains

Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost

Designing multi-period supply chain network considering risk and emission: a multi-objective approach

This research formulates a multi-objective problem (MOP) for supply chain network (SCN) design by incorporating the issues of social relationship, carbon emissions, and supply chain risks such as disruption and opportunism. The proposed MOP includes three conflicting objectives: maximization of total profit, minimization of supply disruption and opportunism risks, and minimization of carbon emission considering a number of supply chain constraints. Furthermore, this research analyses the effect of social relationship levels between different tiers of SCN on the profitability, risk, and emission over the time. In this regard, we focus on responding to the following questions. (1) How does the evolving social relationship affect the objectives of the supply chain (SC)? (2) How do the upstream firms’ relationships affect the relationships of downstream firms, and how these relationships influence the objectives of the SC? (3) How does the supply disruption risk interact with the opportunism risk through supply chain relationships, and how these risks affect the objectives of the SC? (4) How do these three conflicting objectives trade-off? A Pareto-based multi-objective evolutionary algorithm–non-dominated sorting genetic algorithm-II (NSGA-II) has been employed to solve the presented problem. In order to improve the quality of solutions, tuning parameters of the NSGA-II are modulated using Taguchi approach. An illustrative example is presented to manifest the capability of the model and the algorithm. The results obtained evince the robust performance of the proposed MOP

Evaluating the sustainability of urban agriculture projects

Evaluating the sustainability of urban agriculture projects. 5. International Symposium for Farming Systems Design (AGRO2015