Volumetric analysis of arteriovenous malformation using computed tomographic angiography

Thesis (M.A.)--Boston UniversityAn arteriovenous malformation (AVM) is an abnormal collection of blood vessels in which arterial blood flows directly into the draining vein without the normal interposed capillaries. It is an important and growing public healthcare problem affecting millions of Americans and many more people internationally. There are several potential treatment options for the AVM, and the best treatment depends on the maximum length of nidus based on the Spetzler- Martin grading system. However, this grading system is insensitive to volume, because it was designed on the basis of two dimensional digital subtraction angiography images. Here, we report a method using computed tomographic angiography to measure the volume of AVM nidus, as a means for noninvasively assessment. The initial results show statistically significant differences between healthy and AVM subject groups in the direct comparisons of the volume (cm3) through the method we suggested (2.456 ± 1.482, 12.478 ± 5.743 and 53.963 ± 9.338 (mean ± stdev.); Normal (No AVM), Small (< 3cm), Medium (3 ~ 6 cm) respectively; P < 0.005 for all), and they also show the exponential correlation between the AVM volume and the maximum length of a nidus (trend-line: y = 4.4183e0.536x with R2 = 0.945). These results provide more accurate volumetric information. Therefore, this noninvasive imaging-based method is a promising means to measure the volume of AVM using clinically available imaging tools

An Improved Approach for Contrast Enhancement of Spinal Cord Images based on Multiscale Retinex Algorithm

This paper presents a new approach for contrast enhancement of spinal cord medical images based on multirate scheme incorporated into multiscale retinex algorithm. The proposed work here uses HSV color space, since HSV color space separates color details from intensity. The enhancement of medical image is achieved by down sampling the original image into five versions, namely, tiny, small, medium, fine, and normal scale. This is due to the fact that the each versions of the image when independently enhanced and reconstructed results in enormous improvement in the visual quality. Further, the contrast stretching and MultiScale Retinex (MSR) techniques are exploited in order to enhance each of the scaled version of the image. Finally, the enhanced image is obtained by combining each of these scales in an efficient way to obtain the composite enhanced image. The efficiency of the proposed algorithm is validated by using a wavelet energy metric in the wavelet domain. Reconstructed image using proposed method highlights the details (edges and tissues), reduces image noise (Gaussian and Speckle) and improves the overall contrast. The proposed algorithm also enhances sharp edges of the tissue surrounding the spinal cord regions which is useful for diagnosis of spinal cord lesions. Elaborated experiments are conducted on several medical images and results presented show that the enhanced medical pictures are of good quality and is found to be better compared with other researcher methods.Comment: 13 pages, 6 figures, International Journal of Imaging and Robotics. arXiv admin note: text overlap with arXiv:1406.571

Atomic discreteness and the nature of structural equilibrium in conductance histograms of electromigrated Cu-nanocontacts

We investigate the histograms of conductance values obtained during controlled electromigration thinning of Cu thin films. We focus on the question whether the most frequently observed conductance values, apparent as peaks in conductance histograms, can be attributed to the atomic structure of the wire. To this end we calculate the Fourier transform of the conductance histograms. We find all the frequencies matching the highly symmetric crystallographic directions of fcc-Cu. In addition, there are other frequencies explainable by oxidation and possibly formation of hcp-Cu. With these structures we can explain all peaks occurring in the Fourier transform within the relevant range. The results remain the same if only a third of the samples are included. By comparing our results to the ones available in the literature on work-hardened nanowires we find indications that even at low temperatures of the environment, metallic nanocontacts could show enhanced electromigration at low current densities due to defects enhancing electron scattering

Acceleration of Histogram-Based Contrast Enhancement via Selective Downsampling

In this paper, we propose a general framework to accelerate the universal histogram-based image contrast enhancement (CE) algorithms. Both spatial and gray-level selective down- sampling of digital images are adopted to decrease computational cost, while the visual quality of enhanced images is still preserved and without apparent degradation. Mapping function calibration is novelly proposed to reconstruct the pixel mapping on the gray levels missed by downsampling. As two case studies, accelerations of histogram equalization (HE) and the state-of-the-art global CE algorithm, i.e., spatial mutual information and PageRank (SMIRANK), are presented detailedly. Both quantitative and qualitative assessment results have verified the effectiveness of our proposed CE acceleration framework. In typical tests, computational efficiencies of HE and SMIRANK have been speeded up by about 3.9 and 13.5 times, respectively.Comment: accepted by IET Image Processin

Contrast Enhancement of Brightness-Distorted Images by Improved Adaptive Gamma Correction

As an efficient image contrast enhancement (CE) tool, adaptive gamma correction (AGC) was previously proposed by relating gamma parameter with cumulative distribution function (CDF) of the pixel gray levels within an image. ACG deals well with most dimmed images, but fails for globally bright images and the dimmed images with local bright regions. Such two categories of brightness-distorted images are universal in real scenarios, such as improper exposure and white object regions. In order to attenuate such deficiencies, here we propose an improved AGC algorithm. The novel strategy of negative images is used to realize CE of the bright images, and the gamma correction modulated by truncated CDF is employed to enhance the dimmed ones. As such, local over-enhancement and structure distortion can be alleviated. Both qualitative and quantitative experimental results show that our proposed method yields consistently good CE results