Printing of wirelessly rechargeable solid-state supercapacitors for soft, smart contact lenses with continuous operations

Recent advances in smart contact lenses are essential to the realization of medical applications and vision imaging for augmented reality through wireless communication systems. However, previous research on smart contact lenses has been driven by a wired system or wireless power transfer with temporal and spatial restrictions, which can limit their continuous use and require energy storage devices. Also, the rigidity, heat, and large sizes of conventional batteries are not suitable for the soft, smart contact lens. Here, we describe a human pilot trial of a soft, smart contact lens with a wirelessly rechargeable, solid-state supercapacitor for continuous operation. After printing the supercapacitor, all device components (antenna, rectifier, and light-emitting diode) are fully integrated with stretchable structures for this soft lens without obstructing vision. The good reliability against thermal and electromagnetic radiations and the results of the in vivo tests provide the substantial promise of future smart contact lenses

Investigation of the Mechanical and Electrical Properties of Elastic Textile/Polymer Composites for Stretchable Electronics at Quasi-Static or Cyclic Mechanical Loads

In the last decade, interest in stretchable electronic systems that can be bent or shaped three-dimensionally has increased. The application of these systems is that they differentiate between two states and derive there from the requirements for the materials used: once formed, but static or permanently flexible. For this purpose, new materials that exceed the limited mechanical properties of thin metal layers as the typical printed circuit board conductor materials have recently gained the interest of research. In this work, novel electrically conductive textiles were used as conductor materials for stretchable circuit boards. Three different fabrics (woven, knitted and nonwoven) made of silver-plated polyamide fibers were investigated for their mechanical and electrical behavior under quasi-static and cyclic mechanical loads with simultaneous monitoring of the electrical resistance. Thereto, the electrically conductive textiles were embedded into a thermoplastic polyurethane dielectric matrix and structured by laser cutting into stretchable conductors. Based on the characterization of the mechanical and electrical material behavior, a life expectancy was derived. The results are compared with previously investigated stretchable circuit boards based on thermoplastic elastomer and meander-shaped conductor tracks made of copper foils. The microstructural changes in the material caused by the applied mechanical loads were analyzed and are discussed in detail to provide a deep understanding of failure mechanisms.EC/H2020/825647/EU/Re-Thinking of Fashion in Research and Artist collaborating development for Urban Manufacturing/REFREA

Civil space technology initiative

The Civil Space Technology Initiative (CSTI) is a major, focused, space technology program of the Office of Aeronautics, Exploration and Technology (OAET) of NASA. The program was initiated to advance technology beyond basic research in order to expand and enhance system and vehicle capabilities for near-term missions. CSTI takes critical technologies to the point at which a user can confidently incorporate the new or expanded capabilities into relatively near-term, high-priority NASA missions. In particular, the CSTI program emphasizes technologies necessary for reliable and efficient access to and operation in Earth orbit as well as for support of scientific missions from Earth orbit

O₂-sensitive microcavity arrays: A new platform for oxygen measurements in 3D cell cultures

Oxygen concentration plays a crucial role in (3D) cell culture. However, the oxygen content in vitro is usually not comparable to the in vivo situation, which is partly due to the fact that most experiments are performed under ambient atmosphere supplemented with 5% CO2, which can lead to hyperoxia. Cultivation under physiological conditions is necessary, but also fails to have suitable measurement methods, especially in 3D cell culture. Current oxygen measurement methods rely on global oxygen measurements (dish or well) and can only be performed in 2D cultures. In this paper, we describe a system that allows the determination of oxygen in 3D cell culture, especially in the microenvironment of single spheroids/organoids. For this purpose, microthermoforming was used to generate microcavity arrays from oxygensensitive polymer films. In these oxygen-sensitive microcavity arrays (sensor arrays), spheroids cannot only be generated but also cultivated further. In initial experiments we could show that the system is able to perform mitochondrial stress tests in spheroid cultures to characterize mitochondrial respiration in 3D. Thus, with the help of sensor arrays, it is possible to determine oxygen label-free and in real-time in the immediate microenvironment of spheroid cultures for the first time

A compact targeted drug delivery mechanism for a next generation wireless capsule endoscope

This paper reports a novel medication release and delivery mechanism as part of a next generation wireless capsule endoscope (WCE) for targeted drug delivery. This subsystem occupies a volume of only 17.9mm3 for the purpose of delivering a 1 ml payload to a target site of interest in the small intestinal tract. An in-depth analysis of the method employed to release and deliver the medication is described and a series of experiments is presented which validates the drug delivery system. The results show that a variable pitch conical compression spring manufactured from stainless steel can deliver 0.59 N when it is fully compressed and that this would be sufficient force to deliver the onboard medication

Comparative study of wall shear stress at the ascending aorta for different mechanical heart valve prostheses

An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing a bileaflet mechanical heart valve (BMHV) with a trileaflet mechanical heart valve (TMHV) in physiological pulsatile flow. Elastic micro-pillar WSS sensors, calibrated by micro-Particle-Image-Velocimetry measurement, are applied to the wall along the ascending aorta. Peak WSS values are observed almost twice in BMHV compared to TMHV. Flow field analyses illuminate that these peaks are linked to the jet-like flows generated in the valves interacting with the aortic wall. Not only the magnitude but also the impact regions are specific for the different valve designs. The side-orifice jets generated by BMHV travel along the aortic wall in the ascending aorta and cause a whole range impact, while the jets generated by TMHV impact further downstream in the ascending aortic generating less severe WSS

Thermoforming of planar polymer optical waveguides for integrated optics in smart packaging materials

The innovations in smart packaging will open up a wide range of opportunities in the future. This work describes the processing of additive manufactured and planar integrated polymer optical waveguides for use in smart packaging products. The previously published combination of flexographic and Aerosol Jet printing is complemented by thermoforming and thus creates three-dimensional integrated multimode waveguides with optical attenuation of 1.9 dB/cm ± 0.1 dB/cm @ 638 nm. These properties will be the basis to develop smart applications in packaging materials